MSF Topic:

Coverage and use of insecticide-treated bed nets in households with children aged under five years in Liberia

Sat, 01 Dec 2012 00:00:00 GMT

Title: Coverage and use of insecticide-treated bed nets in households with children aged under five years in Liberia Authors: Bawo, L. L.; Harries, A. D.; Reid, T.; Massaquoi, M.; Jallah-Macauley, R.; Jones, J. J.; Wesseh, C. S.; Enders, J.; Hinneh, L.

Artemether-Lumefantrine to treat Malaria in pregnancy is associated with reduced placental Haemozoin deposition compared to Quinine in a randomized controlled trial

Thu, 03 May 2012 00:00:00 GMT

Title: Artemether-Lumefantrine to treat Malaria in pregnancy is associated with reduced placental Haemozoin deposition compared to Quinine in a randomized controlled trial Authors: Muehlenbachs, Atis; Nabasumba, Carolyn; McGready, Rose; Turyakira, Eleanor; Tumwebaze, Benon; Dhorda, Mehul; Nyehangane, Dan; Nalusaji, Aisha; Nosten, Franois; Guerin, Philippe J; Piola, Patrice Abstract: Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda demonstrated that artemether-lumefantrine (AL) is not inferior to quinine to treat uncomplicated malaria in pregnancy. Haemozoin can persist in the placenta following clearance of parasites, however there is no data whether ACT can influence the amount of haemozoin or the dynamics of haemozoin clearance.

Glucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malaria

Mon, 30 Apr 2012 00:00:00 GMT

Title: Glucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malaria Authors: Van Malderen, Carine; Van Geertruyden, Jean-Pierre; Machevo, Sonia; González, Raquel; Bassat, Quique; Talisuna, Ambrose; Yeka, Adoke; Nabasumba, Carolyn; Piola, Patrice; Daniel, Atwine; Turyakira, Eleanor; Forret, Pascale; Van Overmeir, Chantal; van Loen, Harry; Robert, Annie; D' Alessandro, Umberto Abstract: Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely stopped because of safety concerns secondary to its associated risk of haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The objective of the study was to assess whether CDA treatment and G6PD deficiency are risk factors for a post-treatment haemoglobin drop in African children<5 years of age with uncomplicated malaria.

Ready-to-use therapeutic food for Catch-up Growth in children after an episode of Plasmodium Falciparum Malaria: an open randomised controlled trial

Wed, 25 Apr 2012 00:00:00 GMT

Title: Ready-to-use therapeutic food for Catch-up Growth in children after an episode of Plasmodium Falciparum Malaria: an open randomised controlled trial Authors: van der Kam, Saskia; Swarthout, Todd; Niragira, Oscar; Froud, Alyson; Sompwe, Eric Mukomena; Mills, Clair; Roll, Stephanie; Tinnemann, Peter; Shanks, Leslie Abstract: Catch-up growth after an infection is essential for children to maintain good nutritional status. To prevent malnutrition, WHO recommends that children are given one additional healthy meal per day during the 2 weeks after onset of illness. We investigated to what extent ready-to-use therapeutic food (RUTF) promotes catch-up growth in children after an acute, uncomplicated episode of Plasmodium falciparum malaria.