http://hdl.handle.net/10144/12147 Tue, 21 May 2013 09:25:08 GMT 2013-05-21T09:25:08Z http://hdl.handle.net/10144/264552 Title: Human african trypanosomiasis in the democratic republic of the congo: a looming emergency? Authors: Hasker, Epco; Lutumba, Pascal; Chappuis, François; Kande, Victor; Potet, Julien; De Weggheleire, Anja; Kambo, Charles; Depoortere, Evelyn; Pécoul, Bernard; Boelaert, Marleen Sat, 01 Dec 2012 00:00:00 GMT http://hdl.handle.net/10144/264552 2012-12-01T00:00:00Z http://hdl.handle.net/10144/272002 Title: In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness Authors: Schmid, Caecilia; Kuemmerle, Andrea; Blum, Johannes; Ghabri, Salah; Kande, Victor; Mutombo, Wilfried; Ilunga, Medard; Lumpungu, Ismael; Mutanda, Sylvain; Nganzobo, Pathou; Tete, Digas; Mubwa, Nono; Kisala, Mays; Blesson, Severine; Mordt, Olaf Valverde Abstract: Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and insufficiently effective in certain areas (melarsoprol). Recently, nifurtimox-eflornithine combination therapy (NECT) demonstrated good safety and efficacy in a randomised controlled trial (RCT) and was added to the World Health Organisation (WHO) essential medicines list (EML). Documentation of its safety profile in field conditions will support its wider use. Thu, 29 Nov 2012 00:00:00 GMT http://hdl.handle.net/10144/272002 2012-11-29T00:00:00Z http://hdl.handle.net/10144/272032 Title: Early prediction of treatment efficacy in Second-Stage Gambiense Human African Trypanosomiasis Authors: Priotto, Gerardo; Chappuis, François; Bastard, Mathieu; Flevaud, Laurence; Etard, Jean-François Abstract: Human African trypanosomiasis is fatal without treatment. The long post-treatment follow-up (24 months) required to assess cure complicates patient management and is a major obstacle in the development of new therapies. We analyzed individual patient data from 12 programs conducted by Médecins Sans Frontières in Uganda, Sudan, Angola, Central African Republic, Republic of Congo and Democratic Republic of Congo searching for early efficacy indicators. Tue, 05 Jun 2012 00:00:00 GMT http://hdl.handle.net/10144/272032 2012-06-05T00:00:00Z http://hdl.handle.net/10144/142190 Title: Accuracy of five algorithms to diagnose gambiense human African trypanosomiasis. Authors: Checchi, Francesco; Chappuis, François; Karunakara, Unni; Priotto, Gerardo; Chandramohan, Daniel Abstract: Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and typically include a screening (serological), confirmation (parasitological) and staging component. There is insufficient evidence on the relative accuracy of these algorithms. This paper presents estimates of the accuracy of five algorithms used by past Médecins Sans Frontières programmes in the Republic of Congo, Southern Sudan and Uganda. Fri, 01 Jul 2011 00:00:00 GMT http://hdl.handle.net/10144/142190 2011-07-01T00:00:00Z