Effectiveness and Safety of Liposomal Amphotericin B for Visceral Leishmaniasis under Routine Program Conditions in Bihar, India

Hdl Handle:
http://hdl.handle.net/10144/114066
Title:
Effectiveness and Safety of Liposomal Amphotericin B for Visceral Leishmaniasis under Routine Program Conditions in Bihar, India
Authors:
Prabhat K. Sinha; Paul Roddy; Pedro Pablo Palma; Alice Kociejowski; María Angeles (Nines) Lima; Vidya Nand Rabi Das; Jitendra Gupta; Nawin Kumar; Gaurab Mitra; Jean-François Saint-Sauveur; Siju Seena; Manica Balasegaram; Fernando Parreño; Krishna Pandey
Journal:
American Journal of Tropical Medicine and Hygiene
Abstract:
We evaluated, through the prospective monitoring of 251 patients at Sadar Hospital in Bihar, India, the effectiveness and safety of 20 mg/kg body weight of liposomal amphotericin B for the treatment of visceral leishmaniasis. The treatment success rates for the intention-to-treat, per protocol, and intention-to-treat worse-case scenario analyses were 98.8%, 99.6%, and 81.3%, respectively. Nearly one-half of patients experienced mild adverse events, but only 1% developed serious but non–life-threatening lips swelling. The lost to follow-up rate was 17.5%. Our findings indicate that the 20 mg/kg body weight treatment dosage is effective and safe under routine program conditions. Given that the exorbitant cost of liposomal amphotericin B is a barrier to its widespread use, we recommend further study to monitor and evaluate a lowered dosage and a shorter treatment course.
Affiliation:
Medecins Sans Frontieres
Publisher:
The American Society of Tropical Medicine and Hygiene
Issue Date:
Aug-2010
URI:
http://hdl.handle.net/10144/114066
DOI:
10.4269/ajtmh.2010.10-0156
Type:
Article
Language:
en
ISSN:
00029637
Appears in Collections:
Leishmaniasis/Kala Azar

Full metadata record

DC FieldValue Language
dc.contributor.authorPrabhat K. Sinhaen
dc.contributor.authorPaul Roddyen
dc.contributor.authorPedro Pablo Palmaen
dc.contributor.authorAlice Kociejowskien
dc.contributor.authorMaría Angeles (Nines) Limaen
dc.contributor.authorVidya Nand Rabi Dasen
dc.contributor.authorJitendra Guptaen
dc.contributor.authorNawin Kumaren
dc.contributor.authorGaurab Mitraen
dc.contributor.authorJean-François Saint-Sauveuren
dc.contributor.authorSiju Seenaen
dc.contributor.authorManica Balasegaramen
dc.contributor.authorFernando Parreñoen
dc.contributor.authorKrishna Pandeyen
dc.date.accessioned2010-10-29T13:51:51Z-
dc.date.available2010-10-29T13:51:51Z-
dc.date.issued2010-08-
dc.identifier.citationAm. J. Trop. Med. Hyg., 83(2), 2010, pp. 357–364en
dc.identifier.issn00029637-
dc.identifier.doi10.4269/ajtmh.2010.10-0156-
dc.identifier.urihttp://hdl.handle.net/10144/114066-
dc.description.abstractWe evaluated, through the prospective monitoring of 251 patients at Sadar Hospital in Bihar, India, the effectiveness and safety of 20 mg/kg body weight of liposomal amphotericin B for the treatment of visceral leishmaniasis. The treatment success rates for the intention-to-treat, per protocol, and intention-to-treat worse-case scenario analyses were 98.8%, 99.6%, and 81.3%, respectively. Nearly one-half of patients experienced mild adverse events, but only 1% developed serious but non–life-threatening lips swelling. The lost to follow-up rate was 17.5%. Our findings indicate that the 20 mg/kg body weight treatment dosage is effective and safe under routine program conditions. Given that the exorbitant cost of liposomal amphotericin B is a barrier to its widespread use, we recommend further study to monitor and evaluate a lowered dosage and a shorter treatment course.en
dc.language.isoenen
dc.publisherThe American Society of Tropical Medicine and Hygieneen
dc.rightsPublished by: American Society of Tropical Medicine and Hygiene, [url]http://www.ajtmh.org[/url] Archived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, [url]http://www.astmh.org[/url]en
dc.titleEffectiveness and Safety of Liposomal Amphotericin B for Visceral Leishmaniasis under Routine Program Conditions in Bihar, Indiaen
dc.typeArticleen
dc.contributor.departmentMedecins Sans Frontieresen
dc.identifier.journalAmerican Journal of Tropical Medicine and Hygieneen
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