MSF Field Research > 1 Published Research and Commentary > Leishmaniasis/Kala Azar > Effectiveness and Safety of Liposomal Amphotericin B for Visceral Leishmaniasis under Routine Program Conditions in Bihar, India

Please use this identifier to cite or link to this item: http://hdl.handle.net/10144/114066
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Title: Effectiveness and Safety of Liposomal Amphotericin B for Visceral Leishmaniasis under Routine Program Conditions in Bihar, India
Authors: Prabhat K. Sinha
Paul Roddy
Pedro Pablo Palma
Alice Kociejowski
María Angeles (Nines) Lima
Vidya Nand Rabi Das
Jitendra Gupta
Nawin Kumar
Gaurab Mitra
Jean-François Saint-Sauveur
Siju Seena
Manica Balasegaram
Fernando Parreño
Krishna Pandey
Affiliation: Medecins Sans Frontieres
Citation: Am. J. Trop. Med. Hyg., 83(2), 2010, pp. 357–364
Publisher: The American Society of Tropical Medicine and Hygiene
Journal: American Journal of Tropical Medicine and Hygiene
Issue Date: Aug-2010
URI: http://hdl.handle.net/10144/114066
DOI: 10.4269/ajtmh.2010.10-0156
Abstract: We evaluated, through the prospective monitoring of 251 patients at Sadar Hospital in Bihar, India, the effectiveness and safety of 20 mg/kg body weight of liposomal amphotericin B for the treatment of visceral leishmaniasis. The treatment success rates for the intention-to-treat, per protocol, and intention-to-treat worse-case scenario analyses were 98.8%, 99.6%, and 81.3%, respectively. Nearly one-half of patients experienced mild adverse events, but only 1% developed serious but non–life-threatening lips swelling. The lost to follow-up rate was 17.5%. Our findings indicate that the 20 mg/kg body weight treatment dosage is effective and safe under routine program conditions. Given that the exorbitant cost of liposomal amphotericin B is a barrier to its widespread use, we recommend further study to monitor and evaluate a lowered dosage and a shorter treatment course.
Type: Article
Language: en
ISSN: 00029637
Rights: Published by: American Society of Tropical Medicine and Hygiene, http://www.ajtmh.org Archived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, http://www.astmh.org
Appears in topics: Leishmaniasis/Kala Azar

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Sep 19, 2014