Outcomes of tuberculosis patients who start antiretroviral therapy under routine programme conditions in Malawi

Hdl Handle:
http://hdl.handle.net/10144/116334
Title:
Outcomes of tuberculosis patients who start antiretroviral therapy under routine programme conditions in Malawi
Authors:
Makombe, S D; Harries, A D; Yu, J K-L; Hochgesang, M; Mhango, E; Weigel, R; Pasulani, O; Fitzgerald, M; Schouten, E J; Libamba, E
Journal:
International Journal of Tuberculosis and Lung Disease
Abstract:
SETTING: Public sector facilities in Malawi providing antiretroviral therapy (ART) to human immunodeficiency virus (HIV) positive patients, including those with tuberculosis (TB). OBJECTIVES: To compare 6-month and 12-month cohort treatment outcomes of HIV-positive TB patients and HIV-positive non-TB patients treated with ART. DESIGN: Retrospective data collection using ART patient master cards and ART patient registers. RESULTS: Between July and September 2005, 7905 patients started ART, 6967 with a non-TB diagnosis and 938 with a diagnosis of active TB. 6-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (77%) compared with non-TB patients (71%) (P < 0.001). Between January and March 2005, 4580 patients started ART, 4179 with a non-TB diagnosis and 401 with a diagnosis of active TB. 12-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (74%) compared with non-TB patients (66%) (P < 0.001). Other outcomes of default and transfer out were also significantly less frequent in TB compared with non-TB patients. CONCLUSION: HIV-positive TB patients on ART in Malawi have generally good treatment outcomes, and more patients need to access this HIV treatment.
Affiliation:
Clinical HIV Unit, Ministry of Health, Lilongwe 3, Malawi; Family Health International, Malawi Country Office, Lilongwe, Malawi; London School of Hygiene and Tropical Medicine, London, UK; Taiwan Medical Mission, Mzuzu Central Hospital, Mzuzu, Malawi; US Centres for Disease Control and Prevention, Malawi Office, Lilongwe, Malawi; Lighthouse Clinic, Lilongwe, Malawi; Médecins sans Frontieres, Brussels, Belgium; Thyolo District Hospital, Thyolo, Malawi; Ministry of Health, Lilongwe, Malawi; Management Sciences for Health, Lilongwe, Malawi
Issue Date:
1-Apr-2007
URI:
http://hdl.handle.net/10144/116334
PubMed ID:
17394687
Additional Links:
http://www.ingentaconnect.com/content/iuatld/ijtld/2007/00000011/00000004/art00009?token=00541c460f0467869e057e2a46762c6b672148702a44702e6e5f7a673f7b2f27375f2a72752d70fae6cc
Type:
Article
Language:
en
ISSN:
1027-3719
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorMakombe, S Den
dc.contributor.authorHarries, A Den
dc.contributor.authorYu, J K-Len
dc.contributor.authorHochgesang, Men
dc.contributor.authorMhango, Een
dc.contributor.authorWeigel, Ren
dc.contributor.authorPasulani, Oen
dc.contributor.authorFitzgerald, Men
dc.contributor.authorSchouten, E Jen
dc.contributor.authorLibamba, Een
dc.date.accessioned2010-11-25T19:09:38Z-
dc.date.available2010-11-25T19:09:38Z-
dc.date.issued2007-04-01-
dc.identifier.citationInt. J. Tuberc. Lung Dis. 2007;11(4):412-6en
dc.identifier.issn1027-3719-
dc.identifier.pmid17394687-
dc.identifier.urihttp://hdl.handle.net/10144/116334-
dc.description.abstractSETTING: Public sector facilities in Malawi providing antiretroviral therapy (ART) to human immunodeficiency virus (HIV) positive patients, including those with tuberculosis (TB). OBJECTIVES: To compare 6-month and 12-month cohort treatment outcomes of HIV-positive TB patients and HIV-positive non-TB patients treated with ART. DESIGN: Retrospective data collection using ART patient master cards and ART patient registers. RESULTS: Between July and September 2005, 7905 patients started ART, 6967 with a non-TB diagnosis and 938 with a diagnosis of active TB. 6-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (77%) compared with non-TB patients (71%) (P < 0.001). Between January and March 2005, 4580 patients started ART, 4179 with a non-TB diagnosis and 401 with a diagnosis of active TB. 12-month cohort outcomes of non-TB and TB patients censored on 31 March 2006 showed significantly more TB patients alive and on ART (74%) compared with non-TB patients (66%) (P < 0.001). Other outcomes of default and transfer out were also significantly less frequent in TB compared with non-TB patients. CONCLUSION: HIV-positive TB patients on ART in Malawi have generally good treatment outcomes, and more patients need to access this HIV treatment.en
dc.language.isoenen
dc.relation.urlhttp://www.ingentaconnect.com/content/iuatld/ijtld/2007/00000011/00000004/art00009?token=00541c460f0467869e057e2a46762c6b672148702a44702e6e5f7a673f7b2f27375f2a72752d70fae6ccen
dc.rightsArchived with thanks to The International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Diseaseen
dc.subject.meshAnti-Retroviral Agentsen
dc.subject.meshComorbidityen
dc.subject.meshHIV Infectionsen
dc.subject.meshHumansen
dc.subject.meshMalawien
dc.subject.meshTreatment Outcomeen
dc.subject.meshTuberculosisen
dc.titleOutcomes of tuberculosis patients who start antiretroviral therapy under routine programme conditions in Malawien
dc.typeArticleen
dc.contributor.departmentClinical HIV Unit, Ministry of Health, Lilongwe 3, Malawi; Family Health International, Malawi Country Office, Lilongwe, Malawi; London School of Hygiene and Tropical Medicine, London, UK; Taiwan Medical Mission, Mzuzu Central Hospital, Mzuzu, Malawi; US Centres for Disease Control and Prevention, Malawi Office, Lilongwe, Malawi; Lighthouse Clinic, Lilongwe, Malawi; Médecins sans Frontieres, Brussels, Belgium; Thyolo District Hospital, Thyolo, Malawi; Ministry of Health, Lilongwe, Malawi; Management Sciences for Health, Lilongwe, Malawien
dc.identifier.journalInternational Journal of Tuberculosis and Lung Diseaseen

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