Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs)

Hdl Handle:
http://hdl.handle.net/10144/116335
Title:
Estimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs)
Authors:
Kindermans, Jean-Marie; Vandenbergh, Daniel; Vreeke, Ed; Olliaro, Piero; D'Altilia, Jean-Pierre
Journal:
Malaria Journal
Abstract:
BACKGROUND: Having reliable forecasts is critical now for producers, malaria-endemic countries and agencies in order to adapt production and procurement of the artemisinin-based combination treatments (ACTs), the new first-line treatments of malaria. There is no ideal method to quantify drug requirements for malaria. Morbidity data give uncertain estimations. This study uses drug consumption to provide elements to help estimate quantities and financial requirements of ACTs. METHODS: The consumption of chloroquine, sulphadoxine/pyrimethamine and quinine both through the private and public sector was assessed in five sub-Saharan Africa countries with different epidemiological patterns (Senegal, Rwanda, Tanzania, Malawi, Zimbabwe). From these data the number of adult treatments per capita was calculated and the volumes and financial implications derived for the whole of Africa. RESULTS: Identifying and obtaining data from the private sector was difficult. The quality of information on drug supply and distribution in countries must be improved. The number of adult treatments per capita and per year in the five countries ranged from 0.18 to 0.50. Current adult treatment prices for ACTs range US$ 1-1.8. Taking the upper range for both volumes and costs, the highest number of adult treatments consumed for Africa was estimated at 314.5 million, corresponding to an overall maximum annual need for financing ACT procurement of US$ 566.1 million. In reality, both the number of cases treated and the cost of treatment are likely to be lower (projections for the lowest consumption estimate with the least expensive ACT would require US $ 113 million per annum). There were substantial variations in the market share between public and private sources among these countries (the public sector share ranging from 98% in Rwanda to 33% in Tanzania). CONCLUSION: Additional studies are required to build a more robust methodology, and to assess current consumptions more accurately in order to better quantify volumes and finances for production and procurement of ACTs.
Affiliation:
AEDES Foundation, Brussels, Belgium; Médecins Sans Frontières, Brussels, Belgium; UNICEF/UNDP/WB/WHO Special Programme for Research & Training in Tropical Diseases (TDR), Geneva, Switzerland
Issue Date:
10-Jul-2007
URI:
http://hdl.handle.net/10144/116335
DOI:
10.1186/1475-2875-6-91
PubMed ID:
17623092
Additional Links:
http://www.malariajournal.com/content/6/1/91
Type:
Article
Language:
en
ISSN:
1475-2875
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorKindermans, Jean-Marieen
dc.contributor.authorVandenbergh, Danielen
dc.contributor.authorVreeke, Eden
dc.contributor.authorOlliaro, Pieroen
dc.contributor.authorD'Altilia, Jean-Pierreen
dc.date.accessioned2010-11-25T19:12:59Z-
dc.date.available2010-11-25T19:12:59Z-
dc.date.issued2007-07-10-
dc.identifier.citationMalar. J. 2007;6:91en
dc.identifier.issn1475-2875-
dc.identifier.pmid17623092-
dc.identifier.doi10.1186/1475-2875-6-91-
dc.identifier.urihttp://hdl.handle.net/10144/116335-
dc.description.abstractBACKGROUND: Having reliable forecasts is critical now for producers, malaria-endemic countries and agencies in order to adapt production and procurement of the artemisinin-based combination treatments (ACTs), the new first-line treatments of malaria. There is no ideal method to quantify drug requirements for malaria. Morbidity data give uncertain estimations. This study uses drug consumption to provide elements to help estimate quantities and financial requirements of ACTs. METHODS: The consumption of chloroquine, sulphadoxine/pyrimethamine and quinine both through the private and public sector was assessed in five sub-Saharan Africa countries with different epidemiological patterns (Senegal, Rwanda, Tanzania, Malawi, Zimbabwe). From these data the number of adult treatments per capita was calculated and the volumes and financial implications derived for the whole of Africa. RESULTS: Identifying and obtaining data from the private sector was difficult. The quality of information on drug supply and distribution in countries must be improved. The number of adult treatments per capita and per year in the five countries ranged from 0.18 to 0.50. Current adult treatment prices for ACTs range US$ 1-1.8. Taking the upper range for both volumes and costs, the highest number of adult treatments consumed for Africa was estimated at 314.5 million, corresponding to an overall maximum annual need for financing ACT procurement of US$ 566.1 million. In reality, both the number of cases treated and the cost of treatment are likely to be lower (projections for the lowest consumption estimate with the least expensive ACT would require US $ 113 million per annum). There were substantial variations in the market share between public and private sources among these countries (the public sector share ranging from 98% in Rwanda to 33% in Tanzania). CONCLUSION: Additional studies are required to build a more robust methodology, and to assess current consumptions more accurately in order to better quantify volumes and finances for production and procurement of ACTs.en
dc.language.isoenen
dc.relation.urlhttp://www.malariajournal.com/content/6/1/91en
dc.rightsPublished by BioMed Central, [url]http://www.malariajournal.com/[/url] Archived on this site by Open Access permissionen
dc.subject.meshAntimalarialsen
dc.subject.meshArtemisininsen
dc.subject.meshChloroquineen
dc.subject.meshDrug Therapyen
dc.subject.meshDrug Therapy, Combinationen
dc.subject.meshHumansen
dc.subject.meshMalariaen
dc.subject.meshMalawien
dc.subject.meshPyrimethamineen
dc.subject.meshRwandaen
dc.subject.meshSenegalen
dc.subject.meshSulfadoxineen
dc.subject.meshTanzaniaen
dc.subject.meshZimbabween
dc.titleEstimating antimalarial drugs consumption in Africa before the switch to artemisinin-based combination therapies (ACTs)en
dc.typeArticleen
dc.contributor.departmentAEDES Foundation, Brussels, Belgium; Médecins Sans Frontières, Brussels, Belgium; UNICEF/UNDP/WB/WHO Special Programme for Research & Training in Tropical Diseases (TDR), Geneva, Switzerlanden
dc.identifier.journalMalaria Journalen

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