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Title: Antimicrobial susceptibility of Neisseria gonorrheae strains in three regions of Armenia
Authors: Hovhannisyan, Gayane
von Schoen-Angerer, Tido
Babayan, Karen
Fenichiu, Olivier
Gaboulaud, Valerie
Affiliation: Princess Margaret Hospital, Toronto, Canada; Medecins sans frontieres, Geneva, Switzerland; Medical-Scientific Center for Dermatology and STI, Yerevan, Armenia; Medecins sans frontieres, Brussels, Belgium; Epicentre, Paris, France
Citation: Sex Transm Dis 2007;34(9):686-8
Journal: Sexually Transmitted Diseases
Issue Date: 1-Sep-2007
URI: http://hdl.handle.net/10144/116999
DOI: 10.1097/01.olq.0000258433.36526.b5
PubMed ID: 17621247
Additional Links: http://journals.lww.com/stdjournal/pages/articleviewer.aspx?year=2007&issue=09000&article=00011&type=abstract
Abstract: OBJECTIVE: There are no data available on gonococcal susceptibility in the Caucasus region. We aimed to determine in vitro antimicrobial susceptibility of Neisseria gonorrheae in Armenia in order to update the national treatment protocol. METHODS: Isolates from men with urethral discharge presenting at 3 STI clinics in 3 different sites of Armenia were used to determine susceptibility of N. gonorrheae strains for 11 antimicrobials using the disc diffusion technique. RESULTS: Among the 101 isolates tested the susceptibility rate for penicillin, doxycycline, and kanamycin were 37.6, 25.7, and 80.2%, respectively. Sensitivity to quinolones was 95% for both ofloxacin and ciprofloxacin. All strains were susceptible to third-generation cephalosporins and to spectinomycin. Only 11% of strains were susceptible to all antibiotics tested. CONCLUSION: Third-generation cephalosporines and spectinomycin are suitable first-line regimens. Quinolones are not advisable as first-line treatment given current borderline susceptibility, known tendency for rapid resistance development in this class, and frequent over-the-counter use of this antibiotic in Armenia.
Type: Article
Language: en
MeSH: Anti-Bacterial Agents
Armenia
Ciprofloxacin
Doxycycline
Gonorrhea
Humans
Kanamycin
Microbial Sensitivity Tests
Neisseria gonorrhoeae
Ofloxacin
Penicillins
ISSN: 0148-5717
Rights: Published by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluwer
Appears in topics: STDs

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