Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

Hdl Handle:
http://hdl.handle.net/10144/120099
Title:
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
Authors:
Dondorp, Arjen M; Fanello, Caterina I; Hendriksen, Ilse C E; Gomes, Ermelinda; Seni, Amir; Chhaganlal, Kajal D; Bojang, Kalifa; Olaosebikan, Rasaq; Anunobi, Nkechinyere; Maitland, Kathryn; Kivaya, Esther; Agbenyega, Tsiri; Nguah, Samuel Blay; Evans, Jennifer; Gesase, Samwel; Kahabuka, Catherine; Mtove, George; Nadjm, Behzad; Deen, Jacqueline; Mwanga-Amumpaire, Juliet; Nansumba, Margaret; Karema, Corine; Umulisa, Noella; Uwimana, Aline; Mokuolu, Olugbenga A; Adedoyin, Olanrewaju T; Johnson, Wahab B R; Tshefu, Antoinette K; Onyamboko, Marie A; Sakulthaew, Tharisara; Ngum, Wirichada Pan; Silamut, Kamolrat; Stepniewska, Kasia; Woodrow, Charles J; Bethell, Delia; Wills, Bridget; Oneko, Martina; Peto, Tim E; von Seidlein, Lorenz; Day, Nicholas P J; White, Nicholas J; AQUAMAT group
Journal:
Lancet
Abstract:
Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria.
Affiliation:
Hospital Central da Beira, Beira, Mozambique; MRC laboratories, Banjul, The Gambia; Komfo Anokye Hospital, Kumasi, Ghana; Kilifi District General Hospital, Kilifi, Kenya; Magunga District Hospital, NIMR-Korogwe Research Laboratory, Tanga, Tanzania; Teule Designated District Hospital, Muheza, Tanzania; NIMR-Amani Centre, Tanga, Tanzania; Malaria Control Program, Ministry of Health, Kigali, Rwanda; University of Ilorin Teaching Hospital, Ilorin, Nigeria; Mbarara University of Science and Technology and Epicentre Research Base, Mbarara, Uganda; Kinshasa School of Public Health—Kingasani Research Centre, Kinshasa, Democratic Republic of the Congo; Mahidol Oxford Tropical MedicineResearch Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Menzies School of Health Research, Casuarina, NT, Australia; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; KEMRI—CDC Kisumu, Kisumu Kenya
Issue Date:
8-Nov-2010
URI:
http://hdl.handle.net/10144/120099
DOI:
10.1016/S0140-6736(10)61924-1
PubMed ID:
21062666
Additional Links:
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61924-1/abstract
Submitted date:
2011-01-19
Type:
Article
Language:
en
ISSN:
1474-547X
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorDondorp, Arjen Men
dc.contributor.authorFanello, Caterina Ien
dc.contributor.authorHendriksen, Ilse C Een
dc.contributor.authorGomes, Ermelindaen
dc.contributor.authorSeni, Amiren
dc.contributor.authorChhaganlal, Kajal Den
dc.contributor.authorBojang, Kalifaen
dc.contributor.authorOlaosebikan, Rasaqen
dc.contributor.authorAnunobi, Nkechinyereen
dc.contributor.authorMaitland, Kathrynen
dc.contributor.authorKivaya, Estheren
dc.contributor.authorAgbenyega, Tsirien
dc.contributor.authorNguah, Samuel Blayen
dc.contributor.authorEvans, Jenniferen
dc.contributor.authorGesase, Samwelen
dc.contributor.authorKahabuka, Catherineen
dc.contributor.authorMtove, Georgeen
dc.contributor.authorNadjm, Behzaden
dc.contributor.authorDeen, Jacquelineen
dc.contributor.authorMwanga-Amumpaire, Julieten
dc.contributor.authorNansumba, Margareten
dc.contributor.authorKarema, Corineen
dc.contributor.authorUmulisa, Noellaen
dc.contributor.authorUwimana, Alineen
dc.contributor.authorMokuolu, Olugbenga Aen
dc.contributor.authorAdedoyin, Olanrewaju Ten
dc.contributor.authorJohnson, Wahab B Ren
dc.contributor.authorTshefu, Antoinette Ken
dc.contributor.authorOnyamboko, Marie Aen
dc.contributor.authorSakulthaew, Tharisaraen
dc.contributor.authorNgum, Wirichada Panen
dc.contributor.authorSilamut, Kamolraten
dc.contributor.authorStepniewska, Kasiaen
dc.contributor.authorWoodrow, Charles Jen
dc.contributor.authorBethell, Deliaen
dc.contributor.authorWills, Bridgeten
dc.contributor.authorOneko, Martinaen
dc.contributor.authorPeto, Tim Een
dc.contributor.authorvon Seidlein, Lorenzen
dc.contributor.authorDay, Nicholas P Jen
dc.contributor.authorWhite, Nicholas Jen
dc.contributor.authorAQUAMAT groupen
dc.date.accessioned2011-01-20T17:12:27Z-
dc.date.available2011-01-20T17:12:27Z-
dc.date.issued2010-11-08-
dc.date.submitted2011-01-19-
dc.identifier.citationLancet 2010;376(9753):1647-57en
dc.identifier.issn1474-547X-
dc.identifier.pmid21062666-
dc.identifier.doi10.1016/S0140-6736(10)61924-1-
dc.identifier.urihttp://hdl.handle.net/10144/120099-
dc.description.abstractSevere malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment of choice, although evidence from Asia suggests that artesunate is associated with a lower mortality. We compared parenteral treatment with either artesunate or quinine in African children with severe malaria.en
dc.language.isoenen
dc.relation.urlhttp://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)61924-1/abstracten
dc.rightsReproduced on this site with permission of Elsevier Ltd. Please see [url]http://www.thelancet.com/[/url] for further relevant comment.en
dc.subject.meshAfrica South of the Saharaen
dc.subject.meshAntimalarialsen
dc.subject.meshArtemisininsen
dc.subject.meshChild, Preschoolen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshKaplan-Meier Estimateen
dc.subject.meshMalaria, Falciparumen
dc.subject.meshMaleen
dc.subject.meshQuinineen
dc.subject.meshSurvival Rateen
dc.titleArtesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trialen
dc.typeArticleen
dc.contributor.departmentHospital Central da Beira, Beira, Mozambique; MRC laboratories, Banjul, The Gambia; Komfo Anokye Hospital, Kumasi, Ghana; Kilifi District General Hospital, Kilifi, Kenya; Magunga District Hospital, NIMR-Korogwe Research Laboratory, Tanga, Tanzania; Teule Designated District Hospital, Muheza, Tanzania; NIMR-Amani Centre, Tanga, Tanzania; Malaria Control Program, Ministry of Health, Kigali, Rwanda; University of Ilorin Teaching Hospital, Ilorin, Nigeria; Mbarara University of Science and Technology and Epicentre Research Base, Mbarara, Uganda; Kinshasa School of Public Health—Kingasani Research Centre, Kinshasa, Democratic Republic of the Congo; Mahidol Oxford Tropical MedicineResearch Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Menzies School of Health Research, Casuarina, NT, Australia; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; KEMRI—CDC Kisumu, Kisumu Kenyaen
dc.identifier.journalLanceten

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