Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda

Hdl Handle:
http://hdl.handle.net/10144/120332
Title:
Evaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Uganda
Authors:
Ahoua, Laurence; Ayikoru, Harriet; Gnauck, Katherine; Odaru, Grace; Odar, Emmanuel; Ondoa-Onama, Christine; Pinoges, Loretxu; Balkan, Suna; Olson, David; Pujades-Rodríguez, Mar
Journal:
Journal of tropical pediatrics
Abstract:
Prevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19,017 women, 1,037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother-infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07-3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42-4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16-0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.
Affiliation:
Epicentre, Paris, France; Medecins Sans Frontieres, Kampala, Uganda; Arua Regional District Hospital, Ministry of Health, Arua, Uganda; Medecins Sans Frontieres, Paris, France
Issue Date:
13-Jul-2010
URI:
http://hdl.handle.net/10144/120332
DOI:
10.1093/tropej/fmp054
PubMed ID:
19602489
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed
Type:
Article
Language:
en
ISSN:
1465-3664
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorAhoua, Laurenceen
dc.contributor.authorAyikoru, Harrieten
dc.contributor.authorGnauck, Katherineen
dc.contributor.authorOdaru, Graceen
dc.contributor.authorOdar, Emmanuelen
dc.contributor.authorOndoa-Onama, Christineen
dc.contributor.authorPinoges, Loretxuen
dc.contributor.authorBalkan, Sunaen
dc.contributor.authorOlson, Daviden
dc.contributor.authorPujades-Rodríguez, Maren
dc.date.accessioned2011-01-25T16:46:01Z-
dc.date.available2011-01-25T16:46:01Z-
dc.date.issued2010-07-13-
dc.identifier.citationJ. Trop. Pediatr. 2010;56(1):43-52en
dc.identifier.issn1465-3664-
dc.identifier.pmid19602489-
dc.identifier.doi10.1093/tropej/fmp054-
dc.identifier.urihttp://hdl.handle.net/10144/120332-
dc.description.abstractPrevention of mother-to-child transmission (PMTCT) is essential in HIV/AIDS control. We analysed 2000-05 data from mother-infant pairs in our PMTCT programme in rural Uganda, examining programme utilization and outcomes, HIV transmission rates and predictors of death or loss to follow-up (LFU). Out of 19,017 women, 1,037 (5.5%) attending antenatal care services tested HIV positive. Of these, 517 (50%) enrolled in the PMTCT programme and gave birth to 567 infants. Before tracing, 303 (53%) mother-infant pairs were LFU. Reasons for dropout were infant death and lack of understanding of importance of follow-up. Risk of death or LFU was higher among infants with no or incomplete intrapartum prophylaxis (OR = 1.90, 95% CI 1.07-3.36) and of weaning age <6 months (OR 2.55, 95% CI 1.42-4.58), and lower in infants with diagnosed acute illness (OR 0.30, 95% CI 0.16-0.55). Mother-to-child HIV cumulative transmission rate was 8.3%, and 15.5% when HIV-related deaths were considered. Improved tracking of HIV-exposed infants is needed in PMTCT programmes where access to early infant diagnosis is still limited.en
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmeden
dc.rightsPublished by Oxford University Press Archived on this site with kind permission from Oxford University Pressen
dc.subject.meshAdulten
dc.subject.meshAnti-HIV Agentsen
dc.subject.meshCounselingen
dc.subject.meshFemaleen
dc.subject.meshHIV Infectionsen
dc.subject.meshHIV-1en
dc.subject.meshHumansen
dc.subject.meshInfectious Disease Transmission, Verticalen
dc.subject.meshKaplan-Meiers Estimateen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMothersen
dc.subject.meshPostnatal Careen
dc.subject.meshPregnancyen
dc.subject.meshPregnancy Complications, Infectiousen
dc.subject.meshPrenatal Careen
dc.subject.meshRetrospective Studiesen
dc.subject.meshRural Populationen
dc.subject.meshTreatment Outcomeen
dc.subject.meshUgandaen
dc.subject.meshYoung Adulten
dc.titleEvaluation of a 5-year programme to prevent mother-to-child transmission of HIV infection in Northern Ugandaen
dc.typeArticleen
dc.contributor.departmentEpicentre, Paris, France; Medecins Sans Frontieres, Kampala, Uganda; Arua Regional District Hospital, Ministry of Health, Arua, Uganda; Medecins Sans Frontieres, Paris, Franceen
dc.identifier.journalJournal of tropical pediatricsen

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