Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trial

Hdl Handle:
http://hdl.handle.net/10144/127587
Title:
Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trial
Authors:
Hailu, Asrat; Musa, Ahmed; Wasunna, Monique; Balasegaram, Manica; Yifru, Sisay; Mengistu, Getahun; Hurissa, Zewdu; Hailu, Workagegnehu; Weldegebreal, Teklu; Tesfaye, Samson; Makonnen, Eyasu; Khalil, Eltahir; Ahmed, Osama; Fadlalla, Ahmed; El-Hassan, Ahmed; Raheem, Muzamil; Mueller, Marius; Koummuki, Yousif; Rashid, Juma; Mbui, Jane; Mucee, Geoffrey; Njoroge, Simon; Manduku, Veronica; Musibi, Alice; Mutuma, Geoffrey; Kirui, Fredrick; Lodenyo, Hudson; Mutea, Dedan; Kirigi, George; Edwards, Tansy; Smith, Peter; Muthami, Lawrence; Royce, Catherine; Ellis, Sally; Alobo, Moses; Omollo, Raymond; Kesusu, Josephine; Owiti, Rhoda; Kinuthia, John
Journal:
PLoS Neglected Tropical Diseases
Abstract:
Visceral leishmaniasis (VL) is a major health problem in developing countries. The untreated disease is fatal, available treatment is expensive and often toxic, and drug resistance is increasing. Improved treatment options are needed. Paromomycin was shown to be an efficacious first-line treatment with low toxicity in India.
Affiliation:
Addis Ababa University, Ethiopia; Institute of Endemic Diseases, University of Khartoum, Sudan; Centre for Clinical Research, Kenya Medical Research Institute, Kenya; Medecins Sans Frontieres, Amsterdam; Drugs for Neglected Diseases initiative (DNDi), Switzerland; Gondar University, Ethiopia; Arba Minch Hospital, Regional Health Bureau of SNNP state, Ethiopia; Faculty of Medicine, Gedaref University, Sudan; London School of Hygiene and Tropical Medicine, United Kingdom
Issue Date:
26-Oct-2010
URI:
http://hdl.handle.net/10144/127587
DOI:
10.1371/journal.pntd.0000709
PubMed ID:
21049059
Additional Links:
http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000709
Submitted date:
2011-03-10
Type:
Article
Language:
en
ISSN:
1935-2735
Appears in Collections:
Leishmaniasis/Kala Azar

Full metadata record

DC FieldValue Language
dc.contributor.authorHailu, Asraten
dc.contributor.authorMusa, Ahmeden
dc.contributor.authorWasunna, Moniqueen
dc.contributor.authorBalasegaram, Manicaen
dc.contributor.authorYifru, Sisayen
dc.contributor.authorMengistu, Getahunen
dc.contributor.authorHurissa, Zewduen
dc.contributor.authorHailu, Workagegnehuen
dc.contributor.authorWeldegebreal, Tekluen
dc.contributor.authorTesfaye, Samsonen
dc.contributor.authorMakonnen, Eyasuen
dc.contributor.authorKhalil, Eltahiren
dc.contributor.authorAhmed, Osamaen
dc.contributor.authorFadlalla, Ahmeden
dc.contributor.authorEl-Hassan, Ahmeden
dc.contributor.authorRaheem, Muzamilen
dc.contributor.authorMueller, Mariusen
dc.contributor.authorKoummuki, Yousifen
dc.contributor.authorRashid, Jumaen
dc.contributor.authorMbui, Janeen
dc.contributor.authorMucee, Geoffreyen
dc.contributor.authorNjoroge, Simonen
dc.contributor.authorManduku, Veronicaen
dc.contributor.authorMusibi, Aliceen
dc.contributor.authorMutuma, Geoffreyen
dc.contributor.authorKirui, Fredricken
dc.contributor.authorLodenyo, Hudsonen
dc.contributor.authorMutea, Dedanen
dc.contributor.authorKirigi, Georgeen
dc.contributor.authorEdwards, Tansyen
dc.contributor.authorSmith, Peteren
dc.contributor.authorMuthami, Lawrenceen
dc.contributor.authorRoyce, Catherineen
dc.contributor.authorEllis, Sallyen
dc.contributor.authorAlobo, Mosesen
dc.contributor.authorOmollo, Raymonden
dc.contributor.authorKesusu, Josephineen
dc.contributor.authorOwiti, Rhodaen
dc.contributor.authorKinuthia, Johnen
dc.date.accessioned2011-04-06T21:26:14Z-
dc.date.available2011-04-06T21:26:14Z-
dc.date.issued2010-10-26-
dc.date.submitted2011-03-10-
dc.identifier.citationPLoS Negl Trop Dis 2010;4(10):e709en
dc.identifier.issn1935-2735-
dc.identifier.pmid21049059-
dc.identifier.doi10.1371/journal.pntd.0000709-
dc.identifier.urihttp://hdl.handle.net/10144/127587-
dc.description.abstractVisceral leishmaniasis (VL) is a major health problem in developing countries. The untreated disease is fatal, available treatment is expensive and often toxic, and drug resistance is increasing. Improved treatment options are needed. Paromomycin was shown to be an efficacious first-line treatment with low toxicity in India.en
dc.language.isoenen
dc.relation.urlhttp://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000709en
dc.rightsArchived with thanks to PLoS Neglected Tropical Diseasesen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAfrica, Easternen
dc.subject.meshAntiprotozoal Agentsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshFemaleen
dc.subject.meshGeographyen
dc.subject.meshHumansen
dc.subject.meshLeishmania donovanien
dc.subject.meshLeishmaniasis, Visceralen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshParomomycinen
dc.subject.meshTreatment Outcomeen
dc.subject.meshYoung Adulten
dc.titleGeographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trialen
dc.typeArticleen
dc.contributor.departmentAddis Ababa University, Ethiopia; Institute of Endemic Diseases, University of Khartoum, Sudan; Centre for Clinical Research, Kenya Medical Research Institute, Kenya; Medecins Sans Frontieres, Amsterdam; Drugs for Neglected Diseases initiative (DNDi), Switzerland; Gondar University, Ethiopia; Arba Minch Hospital, Regional Health Bureau of SNNP state, Ethiopia; Faculty of Medicine, Gedaref University, Sudan; London School of Hygiene and Tropical Medicine, United Kingdomen
dc.identifier.journalPLoS Neglected Tropical Diseasesen

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