Demographic characteristics and opportunistic diseases associated with attrition during preparation for antiretroviral therapy in primary health centres in Kibera, Kenya.

Hdl Handle:
http://hdl.handle.net/10144/132527
Title:
Demographic characteristics and opportunistic diseases associated with attrition during preparation for antiretroviral therapy in primary health centres in Kibera, Kenya.
Authors:
Tayler-Smith, K; Zachariah, R; Manzi, M; Kizito, W; Vandenbulcke, A; Dunkley, S; von Rege, D; Reid, T; Arnould, L; Suleh, A; Harries, A D
Journal:
Tropical Medicine & International Health : TM & IH
Abstract:
Using routine data from HIV-positive adult patients eligible for antiretroviral therapy (ART), we report on routinely collected demographic characteristics and opportunistic diseases associated with pre-ART attrition (deaths and loss to follow-up). Among 2471 ART eligible patients, enrolled between January 2005 and November 2008, 446 (18%) were lost to attrition pre-ART. Adjusted risk factors significantly associated with pre-ART attrition included age <35 years (Odds Ratio, OR 1.4, 95% Confidence Interval, CI 1.1-1.8), severe malnutrition (OR 1.5, 95% CI 1.1-2.0), active pulmonary tuberculosis (OR 1.6, 95% CI 1.1-2.4), severe bacterial infections including severe bacterial pneumonia (OR 1.9, 95% CI 1.2-2.8) and prolonged unexplained fever (>1 month), (OR 2.6, 95% CI 1.3-5.2). This study highlights a number of clinical markers associated with pre-ART attrition that could serve as 'pointers' or screening tools to identify patients who merit fast-tracking onto ART and/or closer clinical attention and follow-up.
Affiliation:
Medecins sans Frontieres, Medical Department (Operational Research), Brussels Operational Center, Luxembourg, Luxembourg.
Issue Date:
May-2011
URI:
http://hdl.handle.net/10144/132527
DOI:
10.1111/j.1365-3156.2011.02740.x
PubMed ID:
21306485
Language:
en
ISSN:
1365-3156
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorTayler-Smith, Ken
dc.contributor.authorZachariah, Ren
dc.contributor.authorManzi, Men
dc.contributor.authorKizito, Wen
dc.contributor.authorVandenbulcke, Aen
dc.contributor.authorDunkley, Sen
dc.contributor.authorvon Rege, Den
dc.contributor.authorReid, Ten
dc.contributor.authorArnould, Len
dc.contributor.authorSuleh, Aen
dc.contributor.authorHarries, A Den
dc.date.accessioned2011-06-02T14:56:32Z-
dc.date.available2011-06-02T14:56:32Z-
dc.date.issued2011-05-
dc.identifier.citationDemographic characteristics and opportunistic diseases associated with attrition during preparation for antiretroviral therapy in primary health centres in Kibera, Kenya. 2011, 16 (5):579-84 Trop. Med. Int. Healthen
dc.identifier.issn1365-3156-
dc.identifier.pmid21306485-
dc.identifier.doi10.1111/j.1365-3156.2011.02740.x-
dc.identifier.urihttp://hdl.handle.net/10144/132527-
dc.description.abstractUsing routine data from HIV-positive adult patients eligible for antiretroviral therapy (ART), we report on routinely collected demographic characteristics and opportunistic diseases associated with pre-ART attrition (deaths and loss to follow-up). Among 2471 ART eligible patients, enrolled between January 2005 and November 2008, 446 (18%) were lost to attrition pre-ART. Adjusted risk factors significantly associated with pre-ART attrition included age <35 years (Odds Ratio, OR 1.4, 95% Confidence Interval, CI 1.1-1.8), severe malnutrition (OR 1.5, 95% CI 1.1-2.0), active pulmonary tuberculosis (OR 1.6, 95% CI 1.1-2.4), severe bacterial infections including severe bacterial pneumonia (OR 1.9, 95% CI 1.2-2.8) and prolonged unexplained fever (>1 month), (OR 2.6, 95% CI 1.3-5.2). This study highlights a number of clinical markers associated with pre-ART attrition that could serve as 'pointers' or screening tools to identify patients who merit fast-tracking onto ART and/or closer clinical attention and follow-up.en
dc.language.isoenen
dc.rightsArchived on this site with the kind permission of Wiley-Blackwell, [url]http://www.blackwell-synergy.com/loi/tmi[/url]en
dc.titleDemographic characteristics and opportunistic diseases associated with attrition during preparation for antiretroviral therapy in primary health centres in Kibera, Kenya.en
dc.contributor.departmentMedecins sans Frontieres, Medical Department (Operational Research), Brussels Operational Center, Luxembourg, Luxembourg.en
dc.identifier.journalTropical Medicine & International Health : TM & IHen

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