Lessons Learned about Pneumonic Plague Diagnosis from 2 Outbreaks, Democratic Republic of the Congo

Hdl Handle:
http://hdl.handle.net/10144/141432
Title:
Lessons Learned about Pneumonic Plague Diagnosis from 2 Outbreaks, Democratic Republic of the Congo
Authors:
Bertherat, Eric; Thullier, Philippe; Shako, Jean Christophe; England, Kathleen; Kone, Mamadou Lamine; Arntzen, Lorraine; Tomaso, Herbert; Koyange, Louis; Formenty, Pierre; Ekwanzala, Florent; Crestani, Rosa; Ciglenecki, Isa; Ciglenecki, Isa; Rahalison, Lila
Journal:
Emerging Infectious Diseases
Abstract:
Pneumonic plague is a highly transmissible infectious disease for which fatality rates can be high if untreated; it is considered extremely lethal. Without prompt diagnosis and treatment, disease management can be problematic. In the Democratic Republic of the Congo, 2 outbreaks of pneumonic plague occurred during 2005 and 2006. In 2005, because of limitations in laboratory capabilities, etiology was confirmed only through retrospective serologic studies. This prompted modifications in diagnostic strategies, resulting in isolation of Yersinia pestis during the second outbreak. Results from these outbreaks demonstrate the utility of a rapid diagnostic test detecting F1 antigen for initial diagnosis and public health management, as well as the need for specialized sampling kits and trained personnel for quality specimen collection and appropriate specimen handling and preservation for plague confirmation and Y. pestis isolation. Efficient frontline management and a streamlined diagnostic strategy are essential for confirming plague, especially in remote areas.
Affiliation:
World Health Organization, Geneva, Switzerland; Centre de Recherche du Service de Sante des Armees, Grenoble, France; Plague Reference Laboratory, Bunia, Democratic Republic of the Congo; National Institutes of Health, Bethesda, Maryland, USA; World Health Organization, Brazzaville, Republic of Congo; National Health Laboratory Service, Johannesburg, South Africa; Bundeswehr Institute of Microbiology, Munich, Germany; Institut National de la Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo; World Health Organization, Kinshasa; Medecins Sans Frontiere, Bruxelles, Belgium; Medecins sans Frontieres, Geneva; Institut Pasteur, Antananarivo, Madagascar
Issue Date:
25-Apr-2011
URI:
http://hdl.handle.net/10144/141432
PubMed ID:
21529384
Additional Links:
http://www.cdc.gov/EID/content/17/5/778_cme_followup.htm
Submitted date:
2011-05-26
Type:
Article
Language:
en
ISSN:
1080-6059
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorBertherat, Ericen
dc.contributor.authorThullier, Philippeen
dc.contributor.authorShako, Jean Christopheen
dc.contributor.authorEngland, Kathleenen
dc.contributor.authorKone, Mamadou Lamineen
dc.contributor.authorArntzen, Lorraineen
dc.contributor.authorTomaso, Herberten
dc.contributor.authorKoyange, Louisen
dc.contributor.authorFormenty, Pierreen
dc.contributor.authorEkwanzala, Florenten
dc.contributor.authorCrestani, Rosaen
dc.contributor.authorCiglenecki, Isaen
dc.contributor.authorCiglenecki, Isaen
dc.contributor.authorRahalison, Lilaen
dc.date.accessioned2011-08-31T18:56:35Z-
dc.date.available2011-08-31T18:56:35Z-
dc.date.issued2011-04-25-
dc.date.submitted2011-05-26-
dc.identifier.citationEmerg Infect Dis; 2011;17 (5):778-784en
dc.identifier.issn1080-6059-
dc.identifier.pmid21529384-
dc.identifier.urihttp://hdl.handle.net/10144/141432-
dc.description.abstractPneumonic plague is a highly transmissible infectious disease for which fatality rates can be high if untreated; it is considered extremely lethal. Without prompt diagnosis and treatment, disease management can be problematic. In the Democratic Republic of the Congo, 2 outbreaks of pneumonic plague occurred during 2005 and 2006. In 2005, because of limitations in laboratory capabilities, etiology was confirmed only through retrospective serologic studies. This prompted modifications in diagnostic strategies, resulting in isolation of Yersinia pestis during the second outbreak. Results from these outbreaks demonstrate the utility of a rapid diagnostic test detecting F1 antigen for initial diagnosis and public health management, as well as the need for specialized sampling kits and trained personnel for quality specimen collection and appropriate specimen handling and preservation for plague confirmation and Y. pestis isolation. Efficient frontline management and a streamlined diagnostic strategy are essential for confirming plague, especially in remote areas.en
dc.languageENG-
dc.language.isoenen
dc.relation.urlhttp://www.cdc.gov/EID/content/17/5/778_cme_followup.htmen
dc.rightsPublished by Centers for Disease Control (CDC) Archived on this site by permission of CDC, [url]http://www.cdc.gov/ncidod/eid[/url]en
dc.subject.meshPneumonic Plagueen
dc.titleLessons Learned about Pneumonic Plague Diagnosis from 2 Outbreaks, Democratic Republic of the Congoen
dc.typeArticleen
dc.contributor.departmentWorld Health Organization, Geneva, Switzerland; Centre de Recherche du Service de Sante des Armees, Grenoble, France; Plague Reference Laboratory, Bunia, Democratic Republic of the Congo; National Institutes of Health, Bethesda, Maryland, USA; World Health Organization, Brazzaville, Republic of Congo; National Health Laboratory Service, Johannesburg, South Africa; Bundeswehr Institute of Microbiology, Munich, Germany; Institut National de la Recherche Biomedicale, Kinshasa, Democratic Republic of the Congo; World Health Organization, Kinshasa; Medecins Sans Frontiere, Bruxelles, Belgium; Medecins sans Frontieres, Geneva; Institut Pasteur, Antananarivo, Madagascaren
dc.identifier.journalEmerging Infectious Diseasesen

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