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Title: Transmission of Plasmodium vivax in South-Western Uganda: Report of Three Cases in Pregnant Women
Authors: Dhorda, Mehul
Nyehangane, Dan
Rénia, Laurent
Piola, Patrice
Guerin, Philippe J
Snounou, Georges
Affiliation: Epicentre, Mbarara, Uganda; Institut National de la Sante´ et de la Recherche Medicale,Paris, France; Universite´ Pierre et Marie Curie, Faculte´ de Me´decine Pitie´-Salpeˆ trie` re, Paris, France; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Biopolis, Singapore; Epicentre, Paris, France; Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, United Kingdom
Citation: PLoS ONE 2011;6(5):e19801
Journal: PloS One
Issue Date: 13-May-2011
URI: http://hdl.handle.net/10144/141434
DOI: 10.1371/journal.pone.0019801
PubMed ID: 21603649
Additional Links: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0019801
Abstract: Plasmodium vivax is considered to be rare in the predominantly Duffy negative populations of Sub-Saharan Africa, as this red blood cell surface antigen is essential for invasion by the parasite. However, despite only very few reports of molecularly confirmed P. vivax from tropical Africa, serological evidence indicated that 13% of the persons sampled in Congo had been exposed to P. vivax. We identified P. vivax by microscopy in 8 smears from Ugandan pregnant women who had been enrolled in a longitudinal study of malaria in pregnancy. A nested polymerase chain reaction (PCR) protocol was used to detect and identify the Plasmodium parasites present. PCR analysis confirmed the presence of P. vivax for three of the women and analysis of all available samples from these women revealed clinically silent chronic low-grade vivax infections for two of them. The parasites in one woman carried pyrimethamine resistance-associated double non-synonymous mutations in the P. vivax dihydrofolate reductase gene. The three women found infected with P. vivax were Duffy positive as were nine of 68 women randomly selected from the cohort. The data presented from these three case reports is consistent with stable transmission of malaria in a predominantly Duffy negative African population. Given the substantial morbidity associated with vivax infection in non-African endemic areas, it will be important to investigate whether the distribution and prevalence of P. vivax have been underestimated in Sub-Saharan Africa. This is particularly important in the context of the drive to eliminate malaria and its morbidity.
Type: Article
Language: en
MeSH: Malaria, Vivax
Disease Transmission, communicable
Pregnant Women
Duffy blood group protein, human
ISSN: 1932-6203
Rights: Published by Public Library of Science, http://www.plosone.org/ Archived on this site by Open Access permission
Appears in topics: Malaria

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