Evaluation of Three Rapid Tests for Diagnosis of P. Falciparum and P. Vivax Malaria in Colombia.

Hdl Handle:
http://hdl.handle.net/10144/17270
Title:
Evaluation of Three Rapid Tests for Diagnosis of P. Falciparum and P. Vivax Malaria in Colombia.
Authors:
van den Broek, I; Hill, O; Gordillo, F; Angarita, B; Hamade, P; Counihan, H; Guthmann, J P
Journal:
The American Journal of Tropical Medicine and Hygiene
Abstract:
The diagnostic capacity of three malaria rapid diagnostic tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, of whom microscopy confirmed 139 P. falciparum, 279 P. vivax, and 13 mixed P.f/P.v infections and 465 negatives. Paracheck-Pf and NOW-malaria-ICT were more accurate in detecting P. falciparum (sensitivities 90.8% and 90.1%, respectively) in comparison with Optimal-IT (83.6%). NOW showed an acceptable Pf detection rate at low densities (< 500/microL), but resulted in a higher proportion of false positives. For P. vivax diagnosis, Optimal-IT had a higher sensitivity than NOW (91.0% and 81.4%, respectively). The choice between the two Pf/Pv detecting RDTs balances P. falciparum and P. vivax detection rates. Considering some degree of P. falciparum overtreatment and failure to detect all P. vivax cases as more acceptable than missing some cases of P. falciparum, we recommend careful implementation of NOW-malaria-ICT in areas where microscopy is lacking. The price is however still a constraint.
Affiliation:
Médecins sans Frontières (MSF), London, UK. ingrid_vandenbroek@yahoo.com
Issue Date:
Dec-2006
URI:
http://hdl.handle.net/10144/17270
PubMed ID:
17172395
Language:
en
ISSN:
0002-9637
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorvan den Broek, I-
dc.contributor.authorHill, O-
dc.contributor.authorGordillo, F-
dc.contributor.authorAngarita, B-
dc.contributor.authorHamade, P-
dc.contributor.authorCounihan, H-
dc.contributor.authorGuthmann, J P-
dc.date.accessioned2008-01-31T16:43:21Z-
dc.date.available2008-01-31T16:43:21Z-
dc.date.issued2006-12-
dc.identifier.citationEvaluation of Three Rapid Tests for Diagnosis of P. Falciparum and P. Vivax Malaria in Colombia. 2006, 75 (6):1209-15 Am. J. Trop. Med. Hyg.en
dc.identifier.issn0002-9637-
dc.identifier.pmid17172395-
dc.identifier.urihttp://hdl.handle.net/10144/17270-
dc.description.abstractThe diagnostic capacity of three malaria rapid diagnostic tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, of whom microscopy confirmed 139 P. falciparum, 279 P. vivax, and 13 mixed P.f/P.v infections and 465 negatives. Paracheck-Pf and NOW-malaria-ICT were more accurate in detecting P. falciparum (sensitivities 90.8% and 90.1%, respectively) in comparison with Optimal-IT (83.6%). NOW showed an acceptable Pf detection rate at low densities (< 500/microL), but resulted in a higher proportion of false positives. For P. vivax diagnosis, Optimal-IT had a higher sensitivity than NOW (91.0% and 81.4%, respectively). The choice between the two Pf/Pv detecting RDTs balances P. falciparum and P. vivax detection rates. Considering some degree of P. falciparum overtreatment and failure to detect all P. vivax cases as more acceptable than missing some cases of P. falciparum, we recommend careful implementation of NOW-malaria-ICT in areas where microscopy is lacking. The price is however still a constraint.en
dc.language.isoenen
dc.relationhttp://www.ajtmh.orgen
dc.relationhttp://www.ajtmh.orgen
dc.relationhttp://www.ajtmh.org-
dc.rightsArchived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene,www.astmh.orgen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshAnimalsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshColombiaen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMalaria, Falciparumen
dc.subject.meshMalaria, Vivaxen
dc.subject.meshMaleen
dc.subject.meshMicroscopyen
dc.subject.meshMiddle Ageden
dc.subject.meshPlasmodium falciparumen
dc.subject.meshPlasmodium vivaxen
dc.subject.meshQuality Controlen
dc.titleEvaluation of Three Rapid Tests for Diagnosis of P. Falciparum and P. Vivax Malaria in Colombia.en
dc.contributor.departmentMédecins sans Frontières (MSF), London, UK. ingrid_vandenbroek@yahoo.comen
dc.identifier.journalThe American Journal of Tropical Medicine and Hygieneen

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