The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos.

Hdl Handle:
http://hdl.handle.net/10144/17278
Title:
The Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos.
Authors:
Guthmann, J P; Kasparian, S; Phetsouvanh, R; Nathan, N; Garcia, M; Phompida, S; Brockman, A; Gastellu-Etchegorry, M; Legros, D
Journal:
Annals of Tropical Medicine and Parasitology
Abstract:
To assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.
Affiliation:
Epicentre, 8 rue Saint Sabin, 75011 Paris, France. jguthmann@epicentre.msf.org
Publisher:
Published by: Maney Publishing
Issue Date:
Sep-2002
URI:
http://hdl.handle.net/10144/17278
DOI:
10.1179/000349802125001654
PubMed ID:
12396318
Additional Links:
http://www.maney.co.uk/journals/atmp
Language:
en
ISSN:
0003-4983
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorGuthmann, J P-
dc.contributor.authorKasparian, S-
dc.contributor.authorPhetsouvanh, R-
dc.contributor.authorNathan, N-
dc.contributor.authorGarcia, M-
dc.contributor.authorPhompida, S-
dc.contributor.authorBrockman, A-
dc.contributor.authorGastellu-Etchegorry, M-
dc.contributor.authorLegros, D-
dc.date.accessioned2008-01-31T16:07:31Z-
dc.date.available2008-01-31T16:07:31Z-
dc.date.issued2002-09-
dc.identifier.citationThe Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos. 2002, 96 (6):553-7 Ann. Trop. Med. Parasitol.-
dc.identifier.issn0003-4983-
dc.identifier.pmid12396318-
dc.identifier.doi10.1179/000349802125001654-
dc.identifier.urihttp://hdl.handle.net/10144/17278-
dc.description.abstractTo assess the local efficacy of chloroquine for the treatment of acute, uncomplicated, Plasmodium falciparum malaria, children and adults from Sekong province (an area of Laos with a low intensity of transmission) were tested in a 28-day, in-vivo study. Complete data were collected from 88 of the 102 subjects enrolled between October 1999 and September 2000. After genotypic analysis to distinguish recrudescing infections from re-infections, 35 (39.7%, with a 95% confidence interval of 29.5%-50.7%) of these 88 patients were considered treatment failures. These results seriously question the use of chloroquine as the first-line treatment for P. falciparum malaria in the study area.-
dc.language.isoen-
dc.publisherPublished by: Maney Publishing-
dc.relation.urlhttp://www.maney.co.uk/journals/atmp-
dc.rightsArchived on this site with the kind permission of Maney Publishingen_GB
dc.subject.meshAcute Disease-
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAnimals-
dc.subject.meshAntimalarials-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshChloroquine-
dc.subject.meshFemale-
dc.subject.meshGenotype-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshLaos-
dc.subject.meshMalaria, Falciparum-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshPlasmodium falciparum-
dc.subject.meshQuality Control-
dc.subject.meshRecurrence-
dc.subject.meshTreatment Failure-
dc.subject.meshTreatment Outcome-
dc.titleThe Efficacy of Chloroquine for the Treatment of Acute, Uncomplicated, Plasmodium Falciparum Malaria in Laos.-
dc.contributor.departmentEpicentre, 8 rue Saint Sabin, 75011 Paris, France. jguthmann@epicentre.msf.org-
dc.identifier.journalAnnals of Tropical Medicine and Parasitology-

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