High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola.

Hdl Handle:
http://hdl.handle.net/10144/17676
Title:
High Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola.
Authors:
Guthmann, J P; Cohuet, S; Rigutto, C; Fortes, F; Saraiva, N; Kiguli, J; Kyomuhendo, J; Francis, M; Noël, F; Mulemba, M; Balkan, S
Journal:
American Journal of Tropical Medicine and Hygiene
Abstract:
In April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ). After 28 days of follow-up, there were 2/61 (3.2%) recurrent parasitemias in the Coartem group and 4/64 (6.2%) in the ASAQ group (P = 0.72), all classified as re-infections after PCR genotyping (cure rate = 100% [95%CI: 94-100] in both groups). Only one patient (ASAQ group) had gametocytes on day 28 versus five (Coartem) and three (ASAQ) at baseline. Compared with baseline, anemia was significantly improved after 28 days of follow-up in both groups (Coartem: from 54.1% to 13.4%; ASAQ: from 53.1% to 15.9%). Our findings are in favor of a high efficacy of both combinations in Caala. Now that Coartem has been chosen as the new first-line anti-malarial, the challenge is to insure that this drug is available and adequately used.
Affiliation:
Epicentre, Paris, France; Médecins Sans Frontières, Paris, France. jguthmann@epicentre.msf.org
Publisher:
Published by: American Society of Tropical Medicine and Hygiene
Issue Date:
Jul-2006
URI:
http://hdl.handle.net/10144/17676
PubMed ID:
16837721
Additional Links:
http://www.ajtmh.org
Language:
en
ISSN:
0002-9637
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorGuthmann, J P-
dc.contributor.authorCohuet, S-
dc.contributor.authorRigutto, C-
dc.contributor.authorFortes, F-
dc.contributor.authorSaraiva, N-
dc.contributor.authorKiguli, J-
dc.contributor.authorKyomuhendo, J-
dc.contributor.authorFrancis, M-
dc.contributor.authorNoël, F-
dc.contributor.authorMulemba, M-
dc.contributor.authorBalkan, S-
dc.date.accessioned2008-02-07T12:32:45Z-
dc.date.available2008-02-07T12:32:45Z-
dc.date.issued2006-07-
dc.identifier.citationHigh Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola. 2006, 75 (1):143-5 Am. J. Trop. Med. Hyg.en
dc.identifier.issn0002-9637-
dc.identifier.pmid16837721-
dc.identifier.urihttp://hdl.handle.net/10144/17676-
dc.description.abstractIn April 2004, 137 children 6-59 months of age with uncomplicated Plasmodium falciparum (Pf) malaria (Caala, Central Angola) were randomized to receive either artemether-lumefantrine (Coartem) or artesunate + amodiaquine (ASAQ). After 28 days of follow-up, there were 2/61 (3.2%) recurrent parasitemias in the Coartem group and 4/64 (6.2%) in the ASAQ group (P = 0.72), all classified as re-infections after PCR genotyping (cure rate = 100% [95%CI: 94-100] in both groups). Only one patient (ASAQ group) had gametocytes on day 28 versus five (Coartem) and three (ASAQ) at baseline. Compared with baseline, anemia was significantly improved after 28 days of follow-up in both groups (Coartem: from 54.1% to 13.4%; ASAQ: from 53.1% to 15.9%). Our findings are in favor of a high efficacy of both combinations in Caala. Now that Coartem has been chosen as the new first-line anti-malarial, the challenge is to insure that this drug is available and adequately used.en
dc.language.isoenen
dc.publisherPublished by: American Society of Tropical Medicine and Hygiene-
dc.relation.urlhttp://www.ajtmh.org-
dc.rightsArchived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, www.astmh.orgen
dc.subject.meshAmodiaquineen
dc.subject.meshAngolaen
dc.subject.meshAnimalsen
dc.subject.meshAntimalarialsen
dc.subject.meshArtemisininsen
dc.subject.meshChild, Preschoolen
dc.subject.meshDrug Therapy, Combinationen
dc.subject.meshEthanolaminesen
dc.subject.meshFemaleen
dc.subject.meshFluorenesen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMalaria, Falciparumen
dc.subject.meshMaleen
dc.subject.meshSesquiterpenesen
dc.subject.meshTreatment Outcomeen
dc.titleHigh Efficacy of Two Artemisinin-Based Combinations (Artesunate + Amodiaquine and Artemether + Lumefantrine) in Caala, Central Angola.en
dc.contributor.departmentEpicentre, Paris, France; Médecins Sans Frontières, Paris, France. jguthmann@epicentre.msf.orgen
dc.identifier.journalAmerican Journal of Tropical Medicine and Hygieneen

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