Moderate to severe malnutrition in patients with tuberculosis is a risk factor associated with early death.

Hdl Handle:
http://hdl.handle.net/10144/17718
Title:
Moderate to severe malnutrition in patients with tuberculosis is a risk factor associated with early death.
Authors:
Zachariah, R; Spielmann M P; Harries, A D; Salaniponi, F M L
Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Abstract:
A study was conducted in new patients registered with tuberculosis (TB) in a rural district of Malawi to determine (i) the prevalence of malnutrition on admission and (ii) the association between malnutrition and early mortality (defined as death within the first 4 weeks of treatment). There were 1181 patients with TB (576 men and 605 women), whose overall rate of infection with human immunodeficiency virus (HIV) was 80%. 673 TB patients (57%) were malnourished on admission (body mass index [BMI] < 18.5 kg/m2). There were 259 patients (22%) with mild malnutrition (BMI 17.0-18.4 kg/m2), 168 (14%) with moderate malnutrition (BMI 16.0-16.9 kg/m2) and 246 (21%) with severe malnutrition (BMI < 15.9 kg/m2). 95 patients (8%) died during the first 4 weeks. Significant risk factors for early mortality included increasing degrees of malnutrition, age > 35 years, and HIV seropositivity. Among all the 1181 patients, 10.9% of the 414 patients with moderate to severe malnutrition died in the first 4 weeks compared with 6.5% of the 767 patients with normal to mild malnutrition (odds ratio 1.8, 95% confidence interval 1.1-2.7). In patients with TB, BMI < 17.0 kg/m2 is associated with an increased risk of early death.
Affiliation:
Médecins Sans Frontières-Luxembourg, Thyolo District, Malawi. zachariah@internet.lu
Publisher:
Elsevier
Issue Date:
7-Feb-2008
URI:
http://hdl.handle.net/10144/17718
PubMed ID:
12174782
Additional Links:
http://www.sciencedirect.com/science/journal/00359203
Language:
en
ISSN:
0035-9203
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorZachariah, R-
dc.contributor.authorSpielmann M P-
dc.contributor.authorHarries, A D-
dc.contributor.authorSalaniponi, F M L-
dc.date.accessioned2008-02-07T16:19:23Z-
dc.date.available2008-02-07T16:19:23Z-
dc.date.issued2008-02-07T16:19:23Z-
dc.identifier.citationModerate to severe malnutrition in patients with tuberculosis is a risk factor associated with early death., 96 (3):291-4 Trans. R. Soc. Trop. Med. Hyg.en
dc.identifier.issn0035-9203-
dc.identifier.pmid12174782-
dc.identifier.urihttp://hdl.handle.net/10144/17718-
dc.description.abstractA study was conducted in new patients registered with tuberculosis (TB) in a rural district of Malawi to determine (i) the prevalence of malnutrition on admission and (ii) the association between malnutrition and early mortality (defined as death within the first 4 weeks of treatment). There were 1181 patients with TB (576 men and 605 women), whose overall rate of infection with human immunodeficiency virus (HIV) was 80%. 673 TB patients (57%) were malnourished on admission (body mass index [BMI] < 18.5 kg/m2). There were 259 patients (22%) with mild malnutrition (BMI 17.0-18.4 kg/m2), 168 (14%) with moderate malnutrition (BMI 16.0-16.9 kg/m2) and 246 (21%) with severe malnutrition (BMI < 15.9 kg/m2). 95 patients (8%) died during the first 4 weeks. Significant risk factors for early mortality included increasing degrees of malnutrition, age > 35 years, and HIV seropositivity. Among all the 1181 patients, 10.9% of the 414 patients with moderate to severe malnutrition died in the first 4 weeks compared with 6.5% of the 767 patients with normal to mild malnutrition (odds ratio 1.8, 95% confidence interval 1.1-2.7). In patients with TB, BMI < 17.0 kg/m2 is associated with an increased risk of early death.en
dc.language.isoenen
dc.publisherElsevier-
dc.relation.urlhttp://www.sciencedirect.com/science/journal/00359203-
dc.rightsArchived on this site with the kind permission of Elsevier Ltd. and the Royal Society of Tropical Medicine and Hygiene, http://www.rstmh.org/transactions.aspen
dc.subject.meshAIDS-Related Opportunistic Infectionsen
dc.subject.meshAdulten
dc.subject.meshAgeden
dc.subject.meshBody Mass Indexen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshLogistic Modelsen
dc.subject.meshMalawien
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshMultivariate Analysisen
dc.subject.meshNutrition Disordersen
dc.subject.meshNutritional Statusen
dc.subject.meshPrevalenceen
dc.subject.meshRisk Factorsen
dc.subject.meshRural Healthen
dc.subject.meshTuberculosisen
dc.titleModerate to severe malnutrition in patients with tuberculosis is a risk factor associated with early death.en
dc.contributor.departmentMédecins Sans Frontières-Luxembourg, Thyolo District, Malawi. zachariah@internet.luen
dc.identifier.journalTransactions of the Royal Society of Tropical Medicine and Hygieneen
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