Mycobacterium ulcerans infection: control, diagnosis, and treatment.

Hdl Handle:
http://hdl.handle.net/10144/17727
Title:
Mycobacterium ulcerans infection: control, diagnosis, and treatment.
Authors:
Sizaire, V; Nackers, F; Comte, E; Portaels, F
Journal:
The Lancet Infectious Diseases
Abstract:
The skin disease Buruli ulcer, caused by Mycobacterium ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy and mainly affects remote rural African communities. Although the disease is known to be linked to contaminated water, the mode of transmission is not yet understood, which makes it difficult to propose control interventions. The disease is usually detected in its later stages, when it has caused substantial damage and disability. Surgery remains the treatment of choice. Although easy and effective in the early stages of the disease, treatment requires extended excisions and long hospitalisation for the advanced forms of the disease. Currently, no antibiotic treatment has proven effective for all forms of M ulcerans infection and research into a new vaccine is urgently needed. While the scientific community works on developing non-invasive and rapid diagnostic tools, the governments of endemic countries should implement active case finding and health education strategies in their affected communities to detect the disease in its early stages. We review the diagnosis, treatment, and control of Buruli ulcer and list priorities for research and development.
Affiliation:
Médecins Sans Frontières, London, UK. vinciane.sizaire@london.msf.org
Publisher:
Elsevier
Issue Date:
May-2006
URI:
http://hdl.handle.net/10144/17727
DOI:
10.1016/S1473-3099(06)70464-9
PubMed ID:
16631549
Additional Links:
http://www.thelancet.com/journals/laninf
Language:
en
ISSN:
1473-3099
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorSizaire, V-
dc.contributor.authorNackers, F-
dc.contributor.authorComte, E-
dc.contributor.authorPortaels, F-
dc.date.accessioned2008-02-07T16:45:09Z-
dc.date.available2008-02-07T16:45:09Z-
dc.date.issued2006-05-
dc.identifier.citationMycobacterium ulcerans infection: control, diagnosis, and treatment. 2006, 6 (5):288-96notLancet Infect Disen
dc.identifier.issn1473-3099-
dc.identifier.pmid16631549-
dc.identifier.doi10.1016/S1473-3099(06)70464-9-
dc.identifier.urihttp://hdl.handle.net/10144/17727-
dc.description.abstractThe skin disease Buruli ulcer, caused by Mycobacterium ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy and mainly affects remote rural African communities. Although the disease is known to be linked to contaminated water, the mode of transmission is not yet understood, which makes it difficult to propose control interventions. The disease is usually detected in its later stages, when it has caused substantial damage and disability. Surgery remains the treatment of choice. Although easy and effective in the early stages of the disease, treatment requires extended excisions and long hospitalisation for the advanced forms of the disease. Currently, no antibiotic treatment has proven effective for all forms of M ulcerans infection and research into a new vaccine is urgently needed. While the scientific community works on developing non-invasive and rapid diagnostic tools, the governments of endemic countries should implement active case finding and health education strategies in their affected communities to detect the disease in its early stages. We review the diagnosis, treatment, and control of Buruli ulcer and list priorities for research and development.en
dc.language.isoenen
dc.publisherElsevier-
dc.relation.urlhttp://www.thelancet.com/journals/laninf-
dc.rightsReproduced on this site with permission of Elsevier Ltd. Please see www.TheLancet.com/journals/laninf for further relevant comment.en
dc.subject.meshBacterial Vaccinesen
dc.subject.meshDiagnosis, Differentialen
dc.subject.meshHumansen
dc.subject.meshMycobacterium Infections, Atypicalen
dc.subject.meshMycobacterium ulceransen
dc.subject.meshTime Factorsen
dc.subject.meshTreatment Outcomeen
dc.subject.meshUlceren
dc.titleMycobacterium ulcerans infection: control, diagnosis, and treatment.en
dc.contributor.departmentMédecins Sans Frontières, London, UK. vinciane.sizaire@london.msf.orgen
dc.identifier.journalThe Lancet Infectious Diseasesen

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