Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone.

Hdl Handle:
http://hdl.handle.net/10144/18240
Title:
Shigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone.
Authors:
Guerin, P J; Brasher, C; Baron, E; Mic, D; Grimont, F; Ryan, M; Aavitsland, P; Legros, D
Journal:
Lancet
Abstract:
In November 1999, a Médecins Sans Frontières team based in the southeastern part of Sierra Leone reported an increased number of cases of bloody diarrhoea. Shigella dysenteriae serotype 1 (Sd1) was isolated in the early cases. A total of 4218 cases of dysentery were reported in Kenema district from December, 1999, to March, 2000. The overall attack rate was 7.5%. The attack rate was higher among children younger than 5 years than in the rest of the population (11.2% vs 6.8%; relative risk=1.6; 95% CI 1.5-1.8). The case fatality was 3.1%, also higher for children younger than 5 years (6.1% vs 2.1%; relative risk=2.9; 95% CI 2.1-4.1]). Among 583 patients regarded at increased risk of death who were treated with ciprofloxacin in isolation centres, case fatality was 0.9%. A 5-day ciprofloxacin regimen, targeted to the most severe cases of bloody diarrhoea, was highly effective. This is the first time a large outbreak caused by Sd1 has been reported in west Africa.
Affiliation:
Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway. philippe.guerin@epicentre.msf.org
Publisher:
Elsevier
Issue Date:
30-Aug-2003
URI:
http://hdl.handle.net/10144/18240
PubMed ID:
12957094
Additional Links:
http://www.thelancet.com
Language:
en
ISSN:
1474-547X
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorGuerin, P J-
dc.contributor.authorBrasher, C-
dc.contributor.authorBaron, E-
dc.contributor.authorMic, D-
dc.contributor.authorGrimont, F-
dc.contributor.authorRyan, M-
dc.contributor.authorAavitsland, P-
dc.contributor.authorLegros, D-
dc.date.accessioned2008-02-14T10:58:59Z-
dc.date.available2008-02-14T10:58:59Z-
dc.date.issued2003-08-30-
dc.identifier.citationShigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone. 2003, 362 (9385):705-6 Lanceten
dc.identifier.issn1474-547X-
dc.identifier.pmid12957094-
dc.identifier.urihttp://hdl.handle.net/10144/18240-
dc.description.abstractIn November 1999, a Médecins Sans Frontières team based in the southeastern part of Sierra Leone reported an increased number of cases of bloody diarrhoea. Shigella dysenteriae serotype 1 (Sd1) was isolated in the early cases. A total of 4218 cases of dysentery were reported in Kenema district from December, 1999, to March, 2000. The overall attack rate was 7.5%. The attack rate was higher among children younger than 5 years than in the rest of the population (11.2% vs 6.8%; relative risk=1.6; 95% CI 1.5-1.8). The case fatality was 3.1%, also higher for children younger than 5 years (6.1% vs 2.1%; relative risk=2.9; 95% CI 2.1-4.1]). Among 583 patients regarded at increased risk of death who were treated with ciprofloxacin in isolation centres, case fatality was 0.9%. A 5-day ciprofloxacin regimen, targeted to the most severe cases of bloody diarrhoea, was highly effective. This is the first time a large outbreak caused by Sd1 has been reported in west Africa.en
dc.language.isoenen
dc.publisherElsevier-
dc.relation.urlhttp://www.thelancet.com-
dc.rightsReproduced on this site with permission of Elsevier Ltd. Please see www.thelancet.com for further relevant comment.en
dc.subject.meshAnti-Infective Agentsen
dc.subject.meshCiprofloxacinen
dc.subject.meshDisease Outbreaksen
dc.subject.meshDysentery, Bacillaryen
dc.subject.meshHumansen
dc.subject.meshSerotypingen
dc.subject.meshShigella dysenteriaeen
dc.subject.meshSierra Leoneen
dc.titleShigella dysenteriae serotype 1 in west Africa: intervention strategy for an outbreak in Sierra Leone.en
dc.contributor.departmentDivision of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway. philippe.guerin@epicentre.msf.orgen
dc.identifier.journalLanceten

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