Short communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi.

Hdl Handle:
http://hdl.handle.net/10144/18241
Title:
Short communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi.
Authors:
Tostmann, A; Boeree, M J; Harries, A D; Sauvageot, D; Banda, H T; Zijlstra, E E
Journal:
Tropical Medicine & International Health
Abstract:
The proportion of patients with antituberculosis drug-induced hepatotoxicity (ATDH) was unexpectedly low during a trial on cotrimoxazole prophylaxis in Malawian HIV-positive pulmonary tuberculosis patients. About 2% of the patients developed grade 2 or 3 hepatotoxicity during tuberculosis (TB) treatment, according to WHO definitions. Data on ATDH in sub-Saharan Africa are limited. Although the numbers are not very strong, our trial and other papers suggest that ATDH is uncommon in this region. These findings are encouraging in that hepatotoxicity may cause less problem than expected, especially in the light of combined HIV/TB treatment, where drug toxicity is a major cause of treatment interruption.
Affiliation:
Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre and University Lung Centre Dekkerswald, Nijmegen, The Netherlands. A.Tostmann@ulc.umcn.nl
Issue Date:
Jul-2007
URI:
http://hdl.handle.net/10144/18241
DOI:
10.1111/j.1365-3156.2007.01871.x
PubMed ID:
17596252
Additional Links:
http://www.blackwell-synergy.com/loi/tmi
Language:
en
ISSN:
1360-2276
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorTostmann, A-
dc.contributor.authorBoeree, M J-
dc.contributor.authorHarries, A D-
dc.contributor.authorSauvageot, D-
dc.contributor.authorBanda, H T-
dc.contributor.authorZijlstra, E E-
dc.date.accessioned2008-02-14T11:00:46Z-
dc.date.available2008-02-14T11:00:46Z-
dc.date.issued2007-07-
dc.identifier.citationShort communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi. 2007, 12 (7):852-5 Trop. Med. Int. Health-
dc.identifier.issn1360-2276-
dc.identifier.pmid17596252-
dc.identifier.doi10.1111/j.1365-3156.2007.01871.x-
dc.identifier.urihttp://hdl.handle.net/10144/18241-
dc.description.abstractThe proportion of patients with antituberculosis drug-induced hepatotoxicity (ATDH) was unexpectedly low during a trial on cotrimoxazole prophylaxis in Malawian HIV-positive pulmonary tuberculosis patients. About 2% of the patients developed grade 2 or 3 hepatotoxicity during tuberculosis (TB) treatment, according to WHO definitions. Data on ATDH in sub-Saharan Africa are limited. Although the numbers are not very strong, our trial and other papers suggest that ATDH is uncommon in this region. These findings are encouraging in that hepatotoxicity may cause less problem than expected, especially in the light of combined HIV/TB treatment, where drug toxicity is a major cause of treatment interruption.-
dc.language.isoen-
dc.relation.urlhttp://www.blackwell-synergy.com/loi/tmi-
dc.rightsArchived on this site with the kind permission of Wiley-Blackwellen_GB
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAge Distribution-
dc.subject.meshAnti-Infective Agents-
dc.subject.meshAntitubercular Agents-
dc.subject.meshDrug Administration Schedule-
dc.subject.meshFemale-
dc.subject.meshHIV Infections-
dc.subject.meshHumans-
dc.subject.meshLiver Diseases-
dc.subject.meshMalawi-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshSex Distribution-
dc.subject.meshTrimethoprim-Sulfamethoxazole Combination-
dc.subject.meshTuberculosis, Pulmonary-
dc.titleShort communication: antituberculosis drug-induced hepatotoxicity is unexpectedly low in HIV-infected pulmonary tuberculosis patients in Malawi.-
dc.contributor.departmentDepartment of Pulmonary Diseases, Radboud University Nijmegen Medical Centre and University Lung Centre Dekkerswald, Nijmegen, The Netherlands. A.Tostmann@ulc.umcn.nl-
dc.identifier.journalTropical Medicine & International Health-

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