Utility of Lymph Node Aspiration in the Diagnosis of Visceral Leishmaniasis in Sudan.

Hdl Handle:
http://hdl.handle.net/10144/18275
Title:
Utility of Lymph Node Aspiration in the Diagnosis of Visceral Leishmaniasis in Sudan.
Authors:
Babiker, Z O E; Davidson, R N N; Mazinda, C; Kipngetich, S; Ritmeijer, K
Journal:
The American Journal of Tropical Medicine and Hygiene
Abstract:
We evaluated lymph node aspiration (LNA) as a simple diagnostic procedure for visceral leishmaniasis (VL). Lymph node aspiration was compared with the direct agglutination test (DAT) using a diagnostic titer > or = 1:6,400 in 7,880 suspected VL patients in eastern Sudan. Compared with DAT, LNA had a sensitivity of 65.1% (95% confidence interval = 63.5-66.6%). Parasite density in LNA correlated strongly with DAT titers (P < 0.0001), and low parasite density accounted for 78.1% of positive LNA results with DAT titers < 1:6,400 (n = 782). Risk factors predictive of a positive LNA result were an age of 1-29 years, male sex, a hemoglobin level < 10.0 g/dL, a DAT titer > or = 1:800, and a location with a higher prevalence of VL. Lymph node and splenic aspirations were similarly accurate as tests of cure after treatment of 50 VL patients in southern Sudan. Pre-treatment LNA results were negative in 20 cases of severe post kala-azar dermal leishmaniasis.
Affiliation:
Médecins Sans Frontières-Holland, Amsterdam, The Netherlands. zahir_babiker@yahoo.co.uk
Publisher:
Published by: American Society of Tropical Medicine and Hygiene
Issue Date:
Apr-2007
URI:
http://hdl.handle.net/10144/18275
PubMed ID:
17426171
Additional Links:
http://www.ajtmh.org
Language:
en
ISSN:
0002-9637
Appears in Collections:
Leishmaniasis/Kala Azar

Full metadata record

DC FieldValue Language
dc.contributor.authorBabiker, Z O E-
dc.contributor.authorDavidson, R N N-
dc.contributor.authorMazinda, C-
dc.contributor.authorKipngetich, S-
dc.contributor.authorRitmeijer, K-
dc.date.accessioned2008-02-14T11:36:19Z-
dc.date.available2008-02-14T11:36:19Z-
dc.date.issued2007-04-
dc.identifier.citationUtility of lymph node aspiration in the diagnosis of visceral leishmaniasis in Sudan. 2007, 76 (4):689-93 Am. J. Trop. Med. Hyg.en
dc.identifier.issn0002-9637-
dc.identifier.pmid17426171-
dc.identifier.urihttp://hdl.handle.net/10144/18275-
dc.description.abstractWe evaluated lymph node aspiration (LNA) as a simple diagnostic procedure for visceral leishmaniasis (VL). Lymph node aspiration was compared with the direct agglutination test (DAT) using a diagnostic titer > or = 1:6,400 in 7,880 suspected VL patients in eastern Sudan. Compared with DAT, LNA had a sensitivity of 65.1% (95% confidence interval = 63.5-66.6%). Parasite density in LNA correlated strongly with DAT titers (P < 0.0001), and low parasite density accounted for 78.1% of positive LNA results with DAT titers < 1:6,400 (n = 782). Risk factors predictive of a positive LNA result were an age of 1-29 years, male sex, a hemoglobin level < 10.0 g/dL, a DAT titer > or = 1:800, and a location with a higher prevalence of VL. Lymph node and splenic aspirations were similarly accurate as tests of cure after treatment of 50 VL patients in southern Sudan. Pre-treatment LNA results were negative in 20 cases of severe post kala-azar dermal leishmaniasis.en
dc.language.isoenen
dc.publisherPublished by: American Society of Tropical Medicine and Hygiene-
dc.relation.urlhttp://www.ajtmh.org-
dc.rightsArchived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene,www.astmh.orgen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAgglutination Testsen
dc.subject.meshAntimony Sodium Gluconateen
dc.subject.meshAntiprotozoal Agentsen
dc.subject.meshBiopsy, Needleen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshLeishmaniasis, Visceralen
dc.subject.meshLymph Nodesen
dc.subject.meshMaleen
dc.subject.meshSeasonsen
dc.subject.meshSensitivity and Specificityen
dc.subject.meshSudanen
dc.titleUtility of Lymph Node Aspiration in the Diagnosis of Visceral Leishmaniasis in Sudan.en
dc.contributor.departmentMédecins Sans Frontières-Holland, Amsterdam, The Netherlands. zahir_babiker@yahoo.co.uken
dc.identifier.journalThe American Journal of Tropical Medicine and Hygieneen

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