WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts.

Hdl Handle:
http://hdl.handle.net/10144/18292
Title:
WHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts.
Authors:
Teck, R; Ascurra, O; Gomani, P; Manzi, M; Pasulani, O; Kusamale, J; Salaniponi, F M L; Humblet, P; Nunn, P; Scano, F; Harries, A D; Zachariah, R
Journal:
The International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Disease
Abstract:
SETTING: Thyolo district, Malawi. OBJECTIVES: To determine in HIV-positive individuals aged over 13 years CD4 lymphocyte counts in patients classified as WHO Clinical Stage III and IV and patients with active and previous tuberculosis (TB). DESIGN: Cross-sectional study. METHODS: CD4 lymphocyte counts were determined in all consecutive HIV-positive individuals presenting to the antiretroviral clinic in WHO Stage III and IV. RESULTS: A CD4 lymphocyte count of < or = 350 cells/microl was found in 413 (90%) of 457 individuals in WHO Stage III and IV, 96% of 77 individuals with active TB, 92% of 65 individuals with a history of pulmonary TB (PTB) in the last year, 91% of 89 individuals with a previous history of PTB beyond 1 year, 81% of 32 individuals with a previous history of extra-pulmonary TB, 93% of 107 individuals with active or past TB with another HIV-related disease and 89% of 158 individuals with active or past TB without another HIV-related disease. CONCLUSIONS: In our setting, nine of 10 HIV-positive individuals presenting in WHO Stage III and IV and with active or previous TB have CD4 counts of < or = 350 cells/microl. It would thus be reasonable, in this or similar settings where CD4 counts are unavailable for clinical management, for all such patients to be considered eligible for antiretroviral therapy.
Affiliation:
Médecins sans Frontières-Luxembourg, Thyolo, Malawi.
Publisher:
International Union Against TB and Lung Disease
Issue Date:
Mar-2005
URI:
http://hdl.handle.net/10144/18292
PubMed ID:
15786887
Additional Links:
http://www.ingentaconnect.com/content/iuatld/ijtld
Language:
en
ISSN:
1027-3719
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorTeck, R-
dc.contributor.authorAscurra, O-
dc.contributor.authorGomani, P-
dc.contributor.authorManzi, M-
dc.contributor.authorPasulani, O-
dc.contributor.authorKusamale, J-
dc.contributor.authorSalaniponi, F M L-
dc.contributor.authorHumblet, P-
dc.contributor.authorNunn, P-
dc.contributor.authorScano, F-
dc.contributor.authorHarries, A D-
dc.contributor.authorZachariah, R-
dc.date.accessioned2008-02-14T11:50:22Z-
dc.date.available2008-02-14T11:50:22Z-
dc.date.issued2005-03-
dc.identifier.citationWHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts. 2005, 9 (3):258-62 Int. J. Tuberc. Lung Dis.en
dc.identifier.issn1027-3719-
dc.identifier.pmid15786887-
dc.identifier.urihttp://hdl.handle.net/10144/18292-
dc.description.abstractSETTING: Thyolo district, Malawi. OBJECTIVES: To determine in HIV-positive individuals aged over 13 years CD4 lymphocyte counts in patients classified as WHO Clinical Stage III and IV and patients with active and previous tuberculosis (TB). DESIGN: Cross-sectional study. METHODS: CD4 lymphocyte counts were determined in all consecutive HIV-positive individuals presenting to the antiretroviral clinic in WHO Stage III and IV. RESULTS: A CD4 lymphocyte count of < or = 350 cells/microl was found in 413 (90%) of 457 individuals in WHO Stage III and IV, 96% of 77 individuals with active TB, 92% of 65 individuals with a history of pulmonary TB (PTB) in the last year, 91% of 89 individuals with a previous history of PTB beyond 1 year, 81% of 32 individuals with a previous history of extra-pulmonary TB, 93% of 107 individuals with active or past TB with another HIV-related disease and 89% of 158 individuals with active or past TB without another HIV-related disease. CONCLUSIONS: In our setting, nine of 10 HIV-positive individuals presenting in WHO Stage III and IV and with active or previous TB have CD4 counts of < or = 350 cells/microl. It would thus be reasonable, in this or similar settings where CD4 counts are unavailable for clinical management, for all such patients to be considered eligible for antiretroviral therapy.en
dc.language.isoenen
dc.publisherInternational Union Against TB and Lung Disease-
dc.relation.urlhttp://www.ingentaconnect.com/content/iuatld/ijtld-
dc.rightsArchived on this site with the kind permission of the International Union Against TB and Lung Disease, http://www.iuatld.orgen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAnti-HIV Agentsen
dc.subject.meshCD4 Lymphocyte Counten
dc.subject.meshCD4-Positive T-Lymphocytesen
dc.subject.meshCross-Sectional Studiesen
dc.subject.meshEligibility Determinationen
dc.subject.meshFemaleen
dc.subject.meshHIV Antibodiesen
dc.subject.meshHIV Infectionsen
dc.subject.meshHIV-1en
dc.subject.meshHIV-2en
dc.subject.meshHumansen
dc.subject.meshMalawien
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshPrevalenceen
dc.subject.meshRetrospective Studiesen
dc.subject.meshSeverity of Illness Indexen
dc.subject.meshTuberculosisen
dc.subject.meshWorld Health Organizationen
dc.titleWHO Clinical Staging of HIV Infection and Disease, Tuberculosis and Eligibility for Antiretroviral Treatment: Relationship to CD4 Lymphocyte Counts.en
dc.contributor.departmentMédecins sans Frontières-Luxembourg, Thyolo, Malawi.en
dc.identifier.journalThe International Journal of Tuberculosis and Lung Disease : the official journal of the International Union against Tuberculosis and Lung Diseaseen

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