Measles vaccine effectiveness in standard and early immunization strategies, Niger, 1995.

Hdl Handle:
http://hdl.handle.net/10144/18298
Title:
Measles vaccine effectiveness in standard and early immunization strategies, Niger, 1995.
Authors:
Kaninda, A V; Legros, D; Jataou, I M; Malfait, P; Maisonneuve, M; Paquet, C; Moren, A
Journal:
The Pediatric Infectious Disease Journal
Abstract:
BACKGROUND: An Expanded Programme on Immunization was started in late 1987 in Niger, including vaccination against measles with one dose of standard titer Schwarz vaccine given to infants after 9 months of age. During epidemics an early two-dose strategy was implemented (one dose between 6 and 8 months and one dose after 9 months). From January 1, 1995, until May 7, 1995, 13 892 measles cases were reported in Niamey, Niger. METHODS: A retrospective cohort study was conducted in a crowded area of Niamey at the end of the outbreak to assess the effectiveness of measles vaccine in standard (after 9 months) and early (before 9 months) immunization strategies under field conditions. RESULTS: Highest measles incidence rates were observed among children <1 year of age. Vaccine effectiveness estimates increased with age at vaccination from 78% with a single dose administered at 6 months of age to 95% at 9 months. Vaccine effectiveness with the early two dose strategy was 93%. CONCLUSIONS: Immunization with a single dose of standard titer Schwarz vaccine before 9 months of age provided higher clinical protection than expected from seropositivity studies. The early two dose strategy is justified in contexts where measles incidence is high before 9 months of age. Our results raise the issue of lowering the recommended age for measles vaccination in developing countries.
Affiliation:
Epicentre, Paris, France. epimail@epicentre.msf.org
Issue Date:
Nov-1998
URI:
http://hdl.handle.net/10144/18298
PubMed ID:
9849988
Language:
en
ISSN:
0891-3668
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorKaninda, A V-
dc.contributor.authorLegros, D-
dc.contributor.authorJataou, I M-
dc.contributor.authorMalfait, P-
dc.contributor.authorMaisonneuve, M-
dc.contributor.authorPaquet, C-
dc.contributor.authorMoren, A-
dc.date.accessioned2008-02-14T12:54:20Z-
dc.date.available2008-02-14T12:54:20Z-
dc.date.issued1998-11-
dc.identifier.citationMeasles vaccine effectiveness in standard and early immunization strategies, Niger, 1995. 1998, 17 (11):1034-9 Pediatr. Infect. Dis. J.en
dc.identifier.issn0891-3668-
dc.identifier.pmid9849988-
dc.identifier.urihttp://hdl.handle.net/10144/18298-
dc.description.abstractBACKGROUND: An Expanded Programme on Immunization was started in late 1987 in Niger, including vaccination against measles with one dose of standard titer Schwarz vaccine given to infants after 9 months of age. During epidemics an early two-dose strategy was implemented (one dose between 6 and 8 months and one dose after 9 months). From January 1, 1995, until May 7, 1995, 13 892 measles cases were reported in Niamey, Niger. METHODS: A retrospective cohort study was conducted in a crowded area of Niamey at the end of the outbreak to assess the effectiveness of measles vaccine in standard (after 9 months) and early (before 9 months) immunization strategies under field conditions. RESULTS: Highest measles incidence rates were observed among children <1 year of age. Vaccine effectiveness estimates increased with age at vaccination from 78% with a single dose administered at 6 months of age to 95% at 9 months. Vaccine effectiveness with the early two dose strategy was 93%. CONCLUSIONS: Immunization with a single dose of standard titer Schwarz vaccine before 9 months of age provided higher clinical protection than expected from seropositivity studies. The early two dose strategy is justified in contexts where measles incidence is high before 9 months of age. Our results raise the issue of lowering the recommended age for measles vaccination in developing countries.en
dc.language.isoenen
dc.rightsPublished by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluweren
dc.subject.meshChild, Preschoolen
dc.subject.meshDeveloping Countriesen
dc.subject.meshDisease Outbreaksen
dc.subject.meshHumansen
dc.subject.meshImmunization Programsen
dc.subject.meshImmunization Scheduleen
dc.subject.meshIncidenceen
dc.subject.meshInfanten
dc.subject.meshMeaslesen
dc.subject.meshMeasles Vaccineen
dc.subject.meshNigeren
dc.subject.meshRetrospective Studiesen
dc.titleMeasles vaccine effectiveness in standard and early immunization strategies, Niger, 1995.en
dc.contributor.departmentEpicentre, Paris, France. epimail@epicentre.msf.orgen
dc.identifier.journalThe Pediatric Infectious Disease Journalen

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