High sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger.

Hdl Handle:
http://hdl.handle.net/10144/18359
Title:
High sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger.
Authors:
Borel, T; Rose, A M C; Guillerm, M; Sidikou, F; Gerstl, S; Djibo, A; Nathan, N; Chanteau, S; Guerin, P J
Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene
Abstract:
There is a great need for a rapid diagnostic test to guide vaccine choice during outbreaks of meningococcal meningitis in resource-poor countries. During a randomised clinical trial conducted during an epidemic of Neisseria meningitidis serogroup A in Niger in 2003, the sensitivity and specificity of the Pastorex latex agglutination test for this serogroup under optimal field conditions were assessed, using culture and/or PCR as the gold standard. Results from 484 samples showed a sensitivity of 88% (95% CI 85-91%) and a specificity of 93% (95% CI 90-95%). Pastorex could be a good alternative to current methods, as it can be performed in a local laboratory with rapid results and is highly specific. Sensitivity can be improved with prior microscopy where feasible. A study specifically to evaluate the Pastorex test under epidemic conditions, using laboratories with limited resources, is recommended.
Affiliation:
Epicentre, 8 rue St Sabin, 75011 Paris, France.
Issue Date:
Oct-2006
URI:
http://hdl.handle.net/10144/18359
DOI:
10.1016/j.trstmh.2006.03.002
PubMed ID:
16730766
Language:
en
ISSN:
0035-9203
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorBorel, T-
dc.contributor.authorRose, A M C-
dc.contributor.authorGuillerm, M-
dc.contributor.authorSidikou, F-
dc.contributor.authorGerstl, S-
dc.contributor.authorDjibo, A-
dc.contributor.authorNathan, N-
dc.contributor.authorChanteau, S-
dc.contributor.authorGuerin, P J-
dc.date.accessioned2008-02-14T16:39:05Z-
dc.date.available2008-02-14T16:39:05Z-
dc.date.issued2006-10-
dc.identifier.citationHigh sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger. 2006, 100 (10):964-9 Trans. R. Soc. Trop. Med. Hyg.en
dc.identifier.issn0035-9203-
dc.identifier.pmid16730766-
dc.identifier.doi10.1016/j.trstmh.2006.03.002-
dc.identifier.urihttp://hdl.handle.net/10144/18359-
dc.description.abstractThere is a great need for a rapid diagnostic test to guide vaccine choice during outbreaks of meningococcal meningitis in resource-poor countries. During a randomised clinical trial conducted during an epidemic of Neisseria meningitidis serogroup A in Niger in 2003, the sensitivity and specificity of the Pastorex latex agglutination test for this serogroup under optimal field conditions were assessed, using culture and/or PCR as the gold standard. Results from 484 samples showed a sensitivity of 88% (95% CI 85-91%) and a specificity of 93% (95% CI 90-95%). Pastorex could be a good alternative to current methods, as it can be performed in a local laboratory with rapid results and is highly specific. Sensitivity can be improved with prior microscopy where feasible. A study specifically to evaluate the Pastorex test under epidemic conditions, using laboratories with limited resources, is recommended.en
dc.language.isoenen
dc.rightsArchived with thanks to Transactions of the Royal Society of Tropical Medicine and Hygieneen
dc.subject.meshFalse Negative Reactionsen
dc.subject.meshFalse Positive Reactionsen
dc.subject.meshHumansen
dc.subject.meshLatex Fixation Testsen
dc.subject.meshMeningitis, Meningococcalen
dc.subject.meshNeisseria meningitidisen
dc.subject.meshNigeren
dc.subject.meshPolymerase Chain Reactionen
dc.subject.meshSensitivity and Specificityen
dc.titleHigh sensitivity and specificity of the Pastorex latex agglutination test for Neisseria meningitidis serogroup A during a clinical trial in Niger.en
dc.contributor.departmentEpicentre, 8 rue St Sabin, 75011 Paris, France.en
dc.identifier.journalTransactions of the Royal Society of Tropical Medicine and Hygieneen

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