MSF Field Research > 1 Published Research and Commentary > Malaria > Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya

Please use this identifier to cite or link to this item: http://hdl.handle.net/10144/213269
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Title: Suppression of circulating IgD+CD27+ memory B cells in infants living in a malaria-endemic region of Kenya
Authors: Asito, Amolo S
Piriou, Erwan
Jura, Walter GZO
Ouma, Collins
Odada, Peter S
Ogola, Sidney
Fiore, Nancy
Rochford, Rosemary
Affiliation: Maseno University, Maseno, Kenya; Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya; SUNY Upstate Medical University, Syracuse, NY; Medecins Sans Frontieres-Operational Centre Amsterdam, Amsterdam, The Netherlands
Citation: Mal J 2011; 10:362
Publisher: BioMed Central
Journal: Malaria Journal
Issue Date: 13-Dec-2011
URI: http://hdl.handle.net/10144/213269
DOI: 10.1186/1475-2875-10-362
Additional Links: http://www.malariajournal.com/content/10/1/362
Abstract: Background: Plasmodium falciparum infection leads to alterations in B cell subset distribution. During infancy, development of peripheral B cell subsets is also occurring. However, it is unknown if infants living a malaria endemic region have alterations in B cell subsets that is independent of an age effect. Methods: To evaluate the impact of exposure to P. falciparum on B cell development in infants, flow cytometry was used to analyse the distribution and phenotypic characteristic of B cell subsets in infant cohorts prospectively followed at 12, 18 and 24 months from two geographically proximate regions in western Kenya with divergent malaria exposure i.e. Kisumu (malaria-endemic, n = 24) and Nandi (unstable malaria transmission, n = 21). Results: There was significantly higher frequency and absolute cell numbers of CD19+ B cells in Kisumu relative to Nandi at 12(p = 0.0440), 18(p = 0.0210) and 24 months (p = 0.0493). No differences were observed between the infants from the two sites in frequencies of naïve B cells (IgD+CD27-) or classical memory B cells (IgD-CD27+). However, immature transitional B cells (CD19+CD10+CD34-) were higher in Kisumu relative to Nandi at all three ages. In contrast, the levels of non-class switched memory B cells (CD19+IgD+CD27+) were significantly lower overall in Kisumu relative to Nandi at significantly at 12 (p = 0.0144), 18 (p = 0.0013) and 24 months (p = 0.0129). Conclusions: These data suggest that infants living in malaria endemic regions have altered B cell subset distribution. Further studies are needed to understand the functional significance of these changes and long-term impact on ability of these infants to develop antibody responses to P. falciparum and heterologous infections.
Type: Article
Language: en
MeSH: Malaria
Infant
ISSN: 1475-2875
Rights: Published by BioMed Central, http://www.malariajournal.com/ Archived on this site by Open Access permission
Appears in topics: Malaria

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