High prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010

Hdl Handle:
http://hdl.handle.net/10144/220337
Title:
High prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010
Authors:
Sanchez-Padilla, Elisabeth; Dlamini, Themba; Ascorra, Alexandra; Rüsch-Gerdes, Sabine; Tefera, Zerihun Demissie; Calain, Philippe; de la Tour, Roberto; Jochims, Frauke; Richter, Elvira; Bonnet, Maryline
Journal:
Emerging Infectious Diseases
Abstract:
In Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world's highest HIV and TB prevalences. Therefore, we conducted a national survey in 2009-2010 to measure prevalence of drug-resistant TB. Of 988 patients screened, 420 new case-patients and 420 previously treated case-patients met the study criteria. Among culture-positive patients, 15.3% new case-patients and 49.5% previously treated case-patients harbored drug-resistant strains. MDR TB prevalence was 7.7% and 33.8% among new case-patients and previously treated case-patients, respectively. HIV infection and past TB treatment were independently associated with MDR TB. The findings assert the need for wide-scale intervention in resource-limited contexts such as Swaziland, where diagnostic and treatment facilities and health personnel are lacking.
Affiliation:
Epicentre, Paris, France; National Tuberculosis Control Programme, Mbabane, Swaziland; National Reference Center for Mycobacteria, Borstel, Germany; Médecins Sans Frontières, Geneva, Switzerland
Publisher:
Center for Disease Control
Issue Date:
Jan-2012
URI:
http://hdl.handle.net/10144/220337
DOI:
10.3201/eid1801.110850
PubMed ID:
22260950
Additional Links:
http://wwwnc.cdc.gov/eid/article/18/1/11-0850_article.htm
Type:
Article
Language:
en
ISSN:
1080-6059
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorSanchez-Padilla, Elisabethen
dc.contributor.authorDlamini, Thembaen
dc.contributor.authorAscorra, Alexandraen
dc.contributor.authorRüsch-Gerdes, Sabineen
dc.contributor.authorTefera, Zerihun Demissieen
dc.contributor.authorCalain, Philippeen
dc.contributor.authorde la Tour, Robertoen
dc.contributor.authorJochims, Fraukeen
dc.contributor.authorRichter, Elviraen
dc.contributor.authorBonnet, Marylineen
dc.date.accessioned2012-04-24T17:44:00Z-
dc.date.available2012-04-24T17:44:00Z-
dc.date.issued2012-01-
dc.identifier.citationEmerg Infect Dis 2012; 18:1en
dc.identifier.issn1080-6059-
dc.identifier.pmid22260950-
dc.identifier.doi10.3201/eid1801.110850-
dc.identifier.urihttp://hdl.handle.net/10144/220337-
dc.description.abstractIn Africa, although emergence of multidrug-resistant (MDR) tuberculosis (TB) represents a serious threat in countries severely affected by the HIV epidemic, most countries lack drug-resistant TB data. This finding was particularly true in the Kingdom of Swaziland, which has the world's highest HIV and TB prevalences. Therefore, we conducted a national survey in 2009-2010 to measure prevalence of drug-resistant TB. Of 988 patients screened, 420 new case-patients and 420 previously treated case-patients met the study criteria. Among culture-positive patients, 15.3% new case-patients and 49.5% previously treated case-patients harbored drug-resistant strains. MDR TB prevalence was 7.7% and 33.8% among new case-patients and previously treated case-patients, respectively. HIV infection and past TB treatment were independently associated with MDR TB. The findings assert the need for wide-scale intervention in resource-limited contexts such as Swaziland, where diagnostic and treatment facilities and health personnel are lacking.en
dc.language.isoenen
dc.publisherCenter for Disease Controlen
dc.relation.urlhttp://wwwnc.cdc.gov/eid/article/18/1/11-0850_article.htmen
dc.rightsPublished by Centers for Disease Control (CDC) Archived on this site by permission of CDC, [url]http://www.cdc.gov/ncidod/eid[/url]en
dc.subject.meshTuberculosis, Multidrug-Resistanten
dc.titleHigh prevalence of multidrug-resistant tuberculosis, Swaziland, 2009-2010en
dc.typeArticleen
dc.contributor.departmentEpicentre, Paris, France; National Tuberculosis Control Programme, Mbabane, Swaziland; National Reference Center for Mycobacteria, Borstel, Germany; Médecins Sans Frontières, Geneva, Switzerlanden
dc.identifier.journalEmerging Infectious Diseasesen

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