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Title: Performance of a Histidine-Rich Protein 2 Rapid Diagnostic Test, Paracheck Pf(R), for Detection of Malaria Infections in Ugandan Pregnant Women.
Authors: Dhorda, Mehul
Piola, Patrice
Nyehangane, Dan
Tumwebaze, Benon
Nalusaji, Aisha
Nabasumba, Carolyn
Turyakira, Eleanor
McGready, Rose
Ashley, Elizabeth
Guerin, Philippe J
Snounou, Georges
Affiliation: Epicentre, Mbarara, Uganda; Unité Mixte de Recherche 945, Institut National de la Santé et de la Recherche Médicale, Paris, France; Université Pierre et Marie Curie, Faculté de Médecine Pitié-Salpêtrière, Paris, France; Epicentre, Paris, France; Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; Mbarara University of Science and Technology, Mbarara, Uganda; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand.
Citation: Performance of a Histidine-Rich Protein 2 Rapid Diagnostic Test, Paracheck Pf(R), for Detection of Malaria Infections in Ugandan Pregnant Women. 2012, 86 (1):93-95notAm J Trop Med Hyg
Publisher: Am.J.trop.Med.Hyg.
Journal: The American Journal of Tropical Medicine and Hygiene
Issue Date: 1-Jan-2012
URI: http://hdl.handle.net/10144/220351
DOI: 10.4269/ajtmh.2012.10-0631
PubMed ID: 22232456
Additional Links: http://www.ajtmh.org
Abstract: Abstract. Improved laboratory diagnosis is critical to reduce the burden of malaria in pregnancy. Peripheral blood smears appear less sensitive than Plasmodium falciparum histidine-rich protein 2-based rapid diagnostic tests (RDTs) for placental malaria infections in studies conducted at delivery. In this study, 81 women in Uganda in the second or third trimester of pregnancy were followed-up until delivery. At each visit, peripheral blood was tested by blood smear, RDT, and nested species-specific polymerase chain reaction (PCR). Sensitivity and specificity of the tests was calculated with PCR, which detected 22 infections of P. falciparum, as the gold standard. The sensitivity and specificity of blood smears were 36.4% (95% confidence interval [CI] = 18.0-59.2%) and 99.6% (95% CI = 97.7-100%), respectively. The corresponding values for RDT were 31.8% (95% CI = 14.7-54.9%) and 100% (95% CI = 98.3-100%). The RDTs could replace blood smears for diagnosis of malaria in pregnancy by virtue of their relative ease of use. Field-based sensitive tests for malaria in pregnancy are urgently needed.
Type: Article
Language: en
Keywords: Malaria
diagnostic test
Paracheck
Uganda
ISSN: 1476-1645
Rights: Archived with thanks to The American Journal of Tropical Medicine and Hygiene
Appears in topics: Malaria

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