Epidemic Visceral Leishmaniasis in Sudan: A Randomized Trial of Aminosidine Plus Sodium Stibogluconate Versus Sodium Stibogluconate Alone.

Hdl Handle:
http://hdl.handle.net/10144/22252
Title:
Epidemic Visceral Leishmaniasis in Sudan: A Randomized Trial of Aminosidine Plus Sodium Stibogluconate Versus Sodium Stibogluconate Alone.
Authors:
Seaman, J; Pryce, D; Sondorp, H; Moody, A; Bryceson, A; Davidson, R N
Journal:
The Journal of Infectious Diseases
Abstract:
In a comparative trial of treatment in southern Sudan, visceral leishmaniasis was diagnosed by the following symptoms: fever for > 1 month, splenomegaly, and antileishmanial direct agglutination test (DAT) titer of > or = 1:25,600. Patients (200) were randomized to receive sodium stibogluconate (Sbv) at 20 mg/kg/day for 30 days (groups S, n = 99) or Sbv at 20 mg/kg/day plus aminosidine at 15 mg/kg/day for 17 days (group AS, n = 101). Of 192 patients who had spleens or lymph nodes aspirated at entry, 134 (70%) were positive for parasites. During treatment, 7% in group S and 4% in group AS died. All 184 patients who completed treatment were clinically cured. At days 15-17, microscopy of aspirates showed that 57 (95%) of 60 in group AS were negative for parasites compared with 47 (81%) of 58 in group S (P = .018). At day 30, 57 (93.4%) of 61 group S aspirates were negative.
Affiliation:
Medecins Sans Frontieres-Holland, Amsterdam.
Publisher:
Published by Infectious Diseases Society of America
Issue Date:
Sep-1993
URI:
http://hdl.handle.net/10144/22252
PubMed ID:
8394861
Additional Links:
http://www.journals.uchicago.edu/toc/jid
Language:
en
ISSN:
0022-1899
Appears in Collections:
Leishmaniasis/Kala Azar

Full metadata record

DC FieldValue Language
dc.contributor.authorSeaman, J-
dc.contributor.authorPryce, D-
dc.contributor.authorSondorp, H-
dc.contributor.authorMoody, A-
dc.contributor.authorBryceson, A-
dc.contributor.authorDavidson, R N-
dc.date.accessioned2008-04-03T14:17:56Z-
dc.date.available2008-04-03T14:17:56Z-
dc.date.issued1993-09-
dc.identifier.citationEpidemic Visceral Leishmaniasis in Sudan: A Randomized Trial of Aminosidine Plus Sodium Stibogluconate Versus Sodium Stibogluconate Alone. 1993, 168 (3):715-20 J. Infect. Dis.en
dc.identifier.issn0022-1899-
dc.identifier.pmid8394861-
dc.identifier.urihttp://hdl.handle.net/10144/22252-
dc.description.abstractIn a comparative trial of treatment in southern Sudan, visceral leishmaniasis was diagnosed by the following symptoms: fever for > 1 month, splenomegaly, and antileishmanial direct agglutination test (DAT) titer of > or = 1:25,600. Patients (200) were randomized to receive sodium stibogluconate (Sbv) at 20 mg/kg/day for 30 days (groups S, n = 99) or Sbv at 20 mg/kg/day plus aminosidine at 15 mg/kg/day for 17 days (group AS, n = 101). Of 192 patients who had spleens or lymph nodes aspirated at entry, 134 (70%) were positive for parasites. During treatment, 7% in group S and 4% in group AS died. All 184 patients who completed treatment were clinically cured. At days 15-17, microscopy of aspirates showed that 57 (95%) of 60 in group AS were negative for parasites compared with 47 (81%) of 58 in group S (P = .018). At day 30, 57 (93.4%) of 61 group S aspirates were negative.en
dc.language.isoenen
dc.publisherPublished by Infectious Diseases Society of Americaen
dc.relation.urlhttp://www.journals.uchicago.edu/toc/jiden
dc.rightsArchived on this site with permission and copyright 200X by the Infectious Diseases Society of Americaen
dc.subject.meshAdolescenten
dc.subject.meshAdulten
dc.subject.meshAntimony Sodium Gluconateen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDisease Outbreaksen
dc.subject.meshDrug Therapy, Combinationen
dc.subject.meshFemaleen
dc.subject.meshGiardiasisen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshLeishmaniasis, Visceralen
dc.subject.meshMalariaen
dc.subject.meshMaleen
dc.subject.meshMiddle Ageden
dc.subject.meshNutrition Disordersen
dc.subject.meshParomomycinen
dc.subject.meshPregnancyen
dc.subject.meshSudanen
dc.subject.meshWeight Lossen
dc.titleEpidemic Visceral Leishmaniasis in Sudan: A Randomized Trial of Aminosidine Plus Sodium Stibogluconate Versus Sodium Stibogluconate Alone.en
dc.contributor.departmentMedecins Sans Frontieres-Holland, Amsterdam.en
dc.identifier.journalThe Journal of Infectious Diseasesen

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