Time to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection.

Hdl Handle:
http://hdl.handle.net/10144/22253
Title:
Time to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection.
Authors:
Tassie, J M; Grabar, S; Lancar, R; Deloumeaux, J; Bentata, M; Costagliola, D
Journal:
Journal of Acquired Immune Deficiency Syndromes (1999)
Abstract:
To estimate the change in AIDS incubation time during three periods characterized by different availability of antiretroviral treatments, data from the French Hospital Database on HIV of 4702 HIV-1-positive subjects with a documented date of infection were analyzed. Times from seroconversion to AIDS were compared in three periods: period 1 from January 1992 to June 1995 (monotherapy); period 2 from July 1995 to June 1996 (dual therapy); and period 3 from July 1996 to June 1999 (triple therapy). Nonparametric survival analyses were performed to account for staggered entries in the database and during each period. From periods 1 to 3, antiretroviral treatments were initiated earlier after infection, more subjects were treated, and the nature of regimens changed (25.6% of subjects were treated with monotherapy in period 1, 34.6% were treated with dual therapy in period 2, and 53.4% were treated with triple therapy in period 3). Compared with period 1, the relative hazard (RH) of AIDS was 0.31 in period 3 (95% confidence interval [CI]: 0.24-0.39). When comparing period 3 with period 2, the RH of AIDS was 0.36 (CI: 0.29-0.45). Assuming a log normal distribution, the median time to AIDS was estimated as 8.0 years in period 1 (CI: 6.0-10.6), 9.8 years in period 2 (CI: 8.5, 11.2), and 20.0 years in period 3 (CI: 17.1-23.3). This lengthening in time to AIDS from 1992 to 1999 was particularly marked in the period after the introduction of triple therapy, including protease inhibitors.
Affiliation:
Institut National de la Santé et de la Recherche Médicale SC4, Faculté de Médecine, St. Antoine Université Pierre et Marie Curie, Paris, France; Epicentre, Paris, France.
Issue Date:
1-May-2002
URI:
http://hdl.handle.net/10144/22253
PubMed ID:
12048367
Language:
en
ISSN:
1525-4135
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorTassie, J M-
dc.contributor.authorGrabar, S-
dc.contributor.authorLancar, R-
dc.contributor.authorDeloumeaux, J-
dc.contributor.authorBentata, M-
dc.contributor.authorCostagliola, D-
dc.date.accessioned2008-04-03T14:30:20Z-
dc.date.available2008-04-03T14:30:20Z-
dc.date.issued2002-05-01-
dc.identifier.citationTime to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection. 2002, 30 (1):81-7 J. Acquir. Immune Defic. Syndr.en
dc.identifier.issn1525-4135-
dc.identifier.pmid12048367-
dc.identifier.urihttp://hdl.handle.net/10144/22253-
dc.description.abstractTo estimate the change in AIDS incubation time during three periods characterized by different availability of antiretroviral treatments, data from the French Hospital Database on HIV of 4702 HIV-1-positive subjects with a documented date of infection were analyzed. Times from seroconversion to AIDS were compared in three periods: period 1 from January 1992 to June 1995 (monotherapy); period 2 from July 1995 to June 1996 (dual therapy); and period 3 from July 1996 to June 1999 (triple therapy). Nonparametric survival analyses were performed to account for staggered entries in the database and during each period. From periods 1 to 3, antiretroviral treatments were initiated earlier after infection, more subjects were treated, and the nature of regimens changed (25.6% of subjects were treated with monotherapy in period 1, 34.6% were treated with dual therapy in period 2, and 53.4% were treated with triple therapy in period 3). Compared with period 1, the relative hazard (RH) of AIDS was 0.31 in period 3 (95% confidence interval [CI]: 0.24-0.39). When comparing period 3 with period 2, the RH of AIDS was 0.36 (CI: 0.29-0.45). Assuming a log normal distribution, the median time to AIDS was estimated as 8.0 years in period 1 (CI: 6.0-10.6), 9.8 years in period 2 (CI: 8.5, 11.2), and 20.0 years in period 3 (CI: 17.1-23.3). This lengthening in time to AIDS from 1992 to 1999 was particularly marked in the period after the introduction of triple therapy, including protease inhibitors.en
dc.language.isoenen
dc.rightsPublished by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluweren
dc.subject.meshAcquired Immunodeficiency Syndromeen
dc.subject.meshAnti-HIV Agentsen
dc.subject.meshCohort Studiesen
dc.subject.meshConfidence Intervalsen
dc.subject.meshDisease Progressionen
dc.subject.meshFemaleen
dc.subject.meshFranceen
dc.subject.meshHIV Infectionsen
dc.subject.meshHIV-1en
dc.subject.meshHospitals, Specialen
dc.subject.meshHumansen
dc.subject.meshMaleen
dc.subject.meshTime Factorsen
dc.titleTime to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection.en
dc.contributor.departmentInstitut National de la Santé et de la Recherche Médicale SC4, Faculté de Médecine, St. Antoine Université Pierre et Marie Curie, Paris, France; Epicentre, Paris, France.en
dc.identifier.journalJournal of Acquired Immune Deficiency Syndromes (1999)en

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