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Title: Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa.
Authors: Coetzee, David
Hilderbrand, K
Boulle, A
Draper, Beverley
Abdullah, Fareed
Goemaere, Eric
Affiliation: Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. dcoetzee@phfm.uct.ac.za
Citation: Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. 2005, 83 (7):489-94 Bull. World Health Organ.
Publisher: WHO
Journal: Bulletin of the World Health Organization
Issue Date: Jul-2005
URI: http://hdl.handle.net/10144/22392
PubMed ID: 16175822
Abstract: OBJECTIVE: The aim of this study was to estimate the field efficacy of the first routine programme for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) initiated in South Africa, in the subdistrict of Khayelitsha. METHODS: A consecutive sample of 658 mother-infant pairs, identified from the PMTCT register from 1 March to 30 November 2003, were identified for enrolment in this study. Details of the regimen received were established and HIV status of the infants at between 6 and 10 weeks of age was determined by qualitative DNA polymerase chain reaction. Zidovudine (AZT) was provided antenatally from week 34 of gestation and during labour. Infant formula milk was-offered to mothers who chose not to breastfeed. The protocol was amended in July 2003 such that women who had received < 2 weeks of treatment with AZT were given a single dose of nevirapine (NVP) at the onset of labour, and the infant received a weight-adjusted dose of NVP within 72 h of delivery. RESULTS: Of the 535 mother-infant pairs (81%) eventually included in the study, 410 (77%) received an effective PMTCT intervention according to the protocol. The rate of transmission of HIV from mother to child was 8.8% (95% confidence interval (CI), 6.2-10.9). A maternal age of > 25 years was the only significant independent risk factor for transmission (odds ratio, 2.12; 95% CI, 1.14-4.07). CONCLUSION: The results of this study demonstrate the feasibility and effectiveness of a large-scale PMTCT programme in an urban public-sector setting.
Language: en
MeSH: Adult
Anti-HIV Agents
Breast Feeding
Cross-Sectional Studies
Disease Transmission, Vertical
Female
HIV Infections
Humans
Infant
Infant, Newborn
Nevirapine
Polymerase Chain Reaction
Pregnancy
Pregnancy Complications, Infectious
Pregnancy Outcome
Program Development
Program Evaluation
South Africa
Treatment Outcome
Zidovudine
ISSN: 0042-9686
Rights: Archived with thanks to the World Health Organization
Appears in topics: HIV/AIDS
Womens/Reproductive Health

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