MSF Field Research >
1 Published Research and Commentary >
Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa.
this identifier to cite or link
to this item:
|Download this article:|
|Apr 4 Coetzee.pdf||157Kb||Adobe PDF|
|Title: ||Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa.|
|Affiliation: ||Infectious Disease Epidemiology Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa. firstname.lastname@example.org|
|Citation: ||Effectiveness of the first district-wide programme for the prevention of mother-to-child transmission of HIV in South Africa. 2005, 83 (7):489-94 Bull. World Health Organ.|
|Journal: ||Bulletin of the World Health Organization|
|Issue Date: ||Jul-2005 |
|PubMed ID: ||16175822|
|Abstract: ||OBJECTIVE: The aim of this study was to estimate the field efficacy of the first routine programme for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV) initiated in South Africa, in the subdistrict of Khayelitsha. METHODS: A consecutive sample of 658 mother-infant pairs, identified from the PMTCT register from 1 March to 30 November 2003, were identified for enrolment in this study. Details of the regimen received were established and HIV status of the infants at between 6 and 10 weeks of age was determined by qualitative DNA polymerase chain reaction. Zidovudine (AZT) was provided antenatally from week 34 of gestation and during labour. Infant formula milk was-offered to mothers who chose not to breastfeed. The protocol was amended in July 2003 such that women who had received < 2 weeks of treatment with AZT were given a single dose of nevirapine (NVP) at the onset of labour, and the infant received a weight-adjusted dose of NVP within 72 h of delivery. RESULTS: Of the 535 mother-infant pairs (81%) eventually included in the study, 410 (77%) received an effective PMTCT intervention according to the protocol. The rate of transmission of HIV from mother to child was 8.8% (95% confidence interval (CI), 6.2-10.9). A maternal age of > 25 years was the only significant independent risk factor for transmission (odds ratio, 2.12; 95% CI, 1.14-4.07). CONCLUSION: The results of this study demonstrate the feasibility and effectiveness of a large-scale PMTCT programme in an urban public-sector setting.|
Disease Transmission, Vertical
Polymerase Chain Reaction
Pregnancy Complications, Infectious
|Rights: ||Archived with thanks to the World Health Organization|
|Appears in topics: ||HIV/AIDS|
|Related articles on PubMed|
Nevirapine and zidovudine at birth to reduce perinatal transmission of HIV in an African setting: a randomized controlled trial.
Taha TE, Kumwenda NI, Hoover DR, Fiscus SA, Kafulafula G, Nkhoma C, Nour S, Chen S, Liomba G, Miotti PG, Broadhead RL
2004 Jul 14
Antiretroviral treatment and prevention of peripartum and postnatal HIV transmission in West Africa: evaluation of a two-tiered approach.
Tonwe-Gold B, Ekouevi DK, Viho I, Amani-Bosse C, Toure S, Coffie PA, Rouet F, Becquet R, Leroy V, El-Sadr WM, Abrams EJ, Dabis F
Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study.
Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C, Heymann SJ, Gilbert PB, Stevens L, Peter T, Kim S, van Widenfelt E, Moffat C, Ndase P, Arimi P, Kebaabetswe P, Mazonde P, Makhema J, McIntosh K, Novitsky V, Lee TH, Marlink R, Lagakos S, Essex M, Mashi Study Team
2006 Aug 16
|See all 757 articles|
All Items in MSF are protected by copyright, with all rights reserved, unless otherwise indicated.