embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation

Hdl Handle:
http://hdl.handle.net/10144/225986
Title:
embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation
Authors:
Plinke, Claudia; Cox, Helen S; Zarkua, Nana; Karimovich, Hamraev A; Braker, Kai; Diel, Roland; Rüsch-Gerdes, Sabine; Feuerriegel, Silke; Niemann, Stefan
Journal:
The Journal of Antimicrobial Chemotherapy
Abstract:
Mechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key role, a significant number of phenotypically ethambutol-resistant strains do not carry mutations in this codon. Here, other mutations in the embCAB operon are suggested to be involved in resistance development.
Affiliation:
Molecular Mycobacteriology, Research Center Borstel, Germany; Macfarlane Burnet Institute for Medical Research and Public Health, Australia; Medecins Sans Frontieres, Uzbekistan; Ministry of Health, Uzbekistan; Medecins Sans Frontieres, Germany; Department of Pneumology, Medical School Hannover (MHH), Germany; National Reference Center for Mycobacteria, Research Center Borstel, Germany
Issue Date:
28-Apr-2010
URI:
http://hdl.handle.net/10144/225986
DOI:
10.1093/jac/dkq120
PubMed ID:
20427375
Additional Links:
http://jac.oxfordjournals.org/content/65/7/1359.abstract
Submitted date:
2011-03-10
Type:
Article
Language:
en
ISSN:
1460-2091
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorPlinke, Claudiaen_GB
dc.contributor.authorCox, Helen Sen_GB
dc.contributor.authorZarkua, Nanaen_GB
dc.contributor.authorKarimovich, Hamraev Aen_GB
dc.contributor.authorBraker, Kaien_GB
dc.contributor.authorDiel, Rolanden_GB
dc.contributor.authorRüsch-Gerdes, Sabineen_GB
dc.contributor.authorFeuerriegel, Silkeen_GB
dc.contributor.authorNiemann, Stefanen_GB
dc.date.accessioned2012-05-25T15:50:08Z-
dc.date.available2012-05-25T15:50:08Z-
dc.date.issued2010-04-28-
dc.date.submitted2011-03-10-
dc.identifier.citationJ Antimicrob Chemother 2010;65(7):1359-67en_GB
dc.identifier.issn1460-2091-
dc.identifier.pmid20427375-
dc.identifier.doi10.1093/jac/dkq120-
dc.identifier.urihttp://hdl.handle.net/10144/225986-
dc.description.abstractMechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key role, a significant number of phenotypically ethambutol-resistant strains do not carry mutations in this codon. Here, other mutations in the embCAB operon are suggested to be involved in resistance development.en_GB
dc.language.isoenen
dc.relation.urlhttp://jac.oxfordjournals.org/content/65/7/1359.abstracten_GB
dc.rightsArchived with thanks to The Journal of Antimicrobial Chemotherapy and Oxford University Pressen_GB
dc.subject.meshAntitubercular Agentsen_GB
dc.subject.meshBacterial Typing Techniquesen_GB
dc.subject.meshCluster Analysisen_GB
dc.subject.meshDNA Fingerprintingen_GB
dc.subject.meshDNA, Bacterialen_GB
dc.subject.meshDrug Resistance, Bacterialen_GB
dc.subject.meshEthambutolen_GB
dc.subject.meshGenotypeen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMicrobial Sensitivity Testsen_GB
dc.subject.meshMutation, Missenseen_GB
dc.subject.meshMycobacterium tuberculosisen_GB
dc.subject.meshOperonen_GB
dc.subject.meshPentosyltransferasesen_GB
dc.subject.meshPoint Mutationen_GB
dc.subject.meshPolymorphism, Geneticen_GB
dc.subject.meshSequence Analysis, DNAen_GB
dc.titleembCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutationen
dc.typeArticleen
dc.contributor.departmentMolecular Mycobacteriology, Research Center Borstel, Germany; Macfarlane Burnet Institute for Medical Research and Public Health, Australia; Medecins Sans Frontieres, Uzbekistan; Ministry of Health, Uzbekistan; Medecins Sans Frontieres, Germany; Department of Pneumology, Medical School Hannover (MHH), Germany; National Reference Center for Mycobacteria, Research Center Borstel, Germanyen_GB
dc.identifier.journalThe Journal of Antimicrobial Chemotherapyen_GB

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