Treatment of Kala-azar in Southern Sudan Using a 17-day Regimen of Sodium Stibogluconate Combined with Paromomycin: A Retrospective Comparison with 30-day Sodium Stibogluconate Monotherapy.

Hdl Handle:
http://hdl.handle.net/10144/22936
Title:
Treatment of Kala-azar in Southern Sudan Using a 17-day Regimen of Sodium Stibogluconate Combined with Paromomycin: A Retrospective Comparison with 30-day Sodium Stibogluconate Monotherapy.
Authors:
Melaku, Y; Collin, S; Keus, K; Gatluak, F; Ritmeijer, K; Davidson, R N
Journal:
The American Journal of Tropical Medicine and Hygiene
Abstract:
Médecins sans Frontières-Holland has treated > 67,000 patients with kala-azar (KA) in southern Sudan since 1989. In 2002, we replaced the standard regimen of 30 days of daily sodium stibogluconate (SSG) with a 17-day regimen of daily SSG combined with paromomycin (PM). We analyzed data for 4,263 primary KA patients treated between 2002 and 2005 in southern Sudan to determine the relative efficacy of the combination therapy regimen (PM/SSG). The initial cure rate among patients treated with PM/SSG was 97.0% compared with 92.4% among patients treated with SSG monotherapy. Relative efficacy of PM/SSG compared with SSG increased over the study period: odds of death in the PM/SSG group were 44% lower (odds ratio [OR] = 0.56, 95% confidence interval [CI] = 0.37-0.84) in 2002, 78% lower (OR = 0.22, 95% CI = 0.10-0.50) in 2003, and 86% lower (OR = 0.14, 95% CI = 0.07-0.27) in 2004-2005. In remote field settings, 17 days of SSG combined with PM gives better survival and initial cure rates than 30 days of SSG monotherapy.
Affiliation:
Médecins sans Frontières-Holland, Amsterdam, The Netherlands.
Publisher:
American Society of Tropical Medicine and Hygiene
Issue Date:
Jul-2007
URI:
http://hdl.handle.net/10144/22936
PubMed ID:
17620635
Additional Links:
http://www.ajtmh.org
Language:
en
ISSN:
0002-9637
Appears in Collections:
Leishmaniasis/Kala Azar

Full metadata record

DC FieldValue Language
dc.contributor.authorMelaku, Y-
dc.contributor.authorCollin, S-
dc.contributor.authorKeus, K-
dc.contributor.authorGatluak, F-
dc.contributor.authorRitmeijer, K-
dc.contributor.authorDavidson, R N-
dc.date.accessioned2008-04-10T15:53:58Z-
dc.date.available2008-04-10T15:53:58Z-
dc.date.issued2007-07-
dc.identifier.citationTreatment of Kala-azar in Southern Sudan Using a 17-day Regimen of Sodium Stibogluconate Combined with Paromomycin: A Retrospective Comparison with 30-day Sodium Stibogluconate Monotherapy. 2007, 77 (1):89-94 Am. J. Trop. Med. Hyg.en
dc.identifier.issn0002-9637-
dc.identifier.pmid17620635-
dc.identifier.urihttp://hdl.handle.net/10144/22936-
dc.description.abstractMédecins sans Frontières-Holland has treated > 67,000 patients with kala-azar (KA) in southern Sudan since 1989. In 2002, we replaced the standard regimen of 30 days of daily sodium stibogluconate (SSG) with a 17-day regimen of daily SSG combined with paromomycin (PM). We analyzed data for 4,263 primary KA patients treated between 2002 and 2005 in southern Sudan to determine the relative efficacy of the combination therapy regimen (PM/SSG). The initial cure rate among patients treated with PM/SSG was 97.0% compared with 92.4% among patients treated with SSG monotherapy. Relative efficacy of PM/SSG compared with SSG increased over the study period: odds of death in the PM/SSG group were 44% lower (odds ratio [OR] = 0.56, 95% confidence interval [CI] = 0.37-0.84) in 2002, 78% lower (OR = 0.22, 95% CI = 0.10-0.50) in 2003, and 86% lower (OR = 0.14, 95% CI = 0.07-0.27) in 2004-2005. In remote field settings, 17 days of SSG combined with PM gives better survival and initial cure rates than 30 days of SSG monotherapy.en
dc.language.isoenen
dc.publisherAmerican Society of Tropical Medicine and Hygieneen
dc.relation.urlhttp://www.ajtmh.orgen
dc.rightsArchived on this site with the kind permission of the American Society of Tropical Medicine and Hygiene, http://www.astmh.orgen
dc.subject.meshAdolescenten
dc.subject.meshAntimony Sodium Gluconateen
dc.subject.meshAntiprotozoal Agentsen
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDrug Administration Scheduleen
dc.subject.meshDrug Therapy, Combinationen
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshInfant, Newbornen
dc.subject.meshLeishmaniasis, Visceralen
dc.subject.meshMaleen
dc.subject.meshMedical Recordsen
dc.subject.meshParomomycinen
dc.subject.meshRetrospective Studiesen
dc.subject.meshSudanen
dc.subject.meshTreatment Outcomeen
dc.titleTreatment of Kala-azar in Southern Sudan Using a 17-day Regimen of Sodium Stibogluconate Combined with Paromomycin: A Retrospective Comparison with 30-day Sodium Stibogluconate Monotherapy.en
dc.contributor.departmentMédecins sans Frontières-Holland, Amsterdam, The Netherlands.en
dc.identifier.journalThe American Journal of Tropical Medicine and Hygieneen

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