Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.

Hdl Handle:
http://hdl.handle.net/10144/23763
Title:
Efficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.
Authors:
Graupner, J; Göbels, K; Grobusch, M P; Lund, A; Richter, J; Häussinger, D
Journal:
Parasitology Research
Abstract:
Falciparum Malaria is hyperendemic in southern Nigeria and chloroquine resistance is an increasing problem. Therefore, the parasitological and haematological response to treatment with amodiaquine was studied in children under 5 years during a 14-day follow-up. Of 105 children who accomplished the study (out of 114 who were enrolled), 95.3% were parasite-negative on thick blood film on day 7, which decreased to 89.5% on day 14. The haemoglobin levels increased on average by 1.3% on day 14 (+/-1.9) and more pronounced in children with anaemia<10 g/dl on enrollment. The number of patients with adverse events (mainly pruritus and nausea) was few. This study shows that amodiaquine is effective, safe and affordable in an area with high resistance to chloroquine.
Affiliation:
Medecins sans Frontières (MSF), Max Euweplein 40, 1001, EA, Amsterdam, The Netherlands.
Issue Date:
Jun-2005
URI:
http://hdl.handle.net/10144/23763
DOI:
10.1007/s00436-005-1325-7
PubMed ID:
15864651
Language:
en
ISSN:
0932-0113
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorGraupner, J-
dc.contributor.authorGöbels, K-
dc.contributor.authorGrobusch, M P-
dc.contributor.authorLund, A-
dc.contributor.authorRichter, J-
dc.contributor.authorHäussinger, D-
dc.date.accessioned2008-04-18T12:15:42Z-
dc.date.available2008-04-18T12:15:42Z-
dc.date.issued2005-06-
dc.identifier.citationEfficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine. 2005, 96 (3):162-5 Parasitol. Res.en
dc.identifier.issn0932-0113-
dc.identifier.pmid15864651-
dc.identifier.doi10.1007/s00436-005-1325-7-
dc.identifier.urihttp://hdl.handle.net/10144/23763-
dc.description.abstractFalciparum Malaria is hyperendemic in southern Nigeria and chloroquine resistance is an increasing problem. Therefore, the parasitological and haematological response to treatment with amodiaquine was studied in children under 5 years during a 14-day follow-up. Of 105 children who accomplished the study (out of 114 who were enrolled), 95.3% were parasite-negative on thick blood film on day 7, which decreased to 89.5% on day 14. The haemoglobin levels increased on average by 1.3% on day 14 (+/-1.9) and more pronounced in children with anaemia<10 g/dl on enrollment. The number of patients with adverse events (mainly pruritus and nausea) was few. This study shows that amodiaquine is effective, safe and affordable in an area with high resistance to chloroquine.en
dc.language.isoenen
dc.rightsArchived on this site with kind permission of Springer Science+Business Media-
dc.subject.meshAmodiaquineen
dc.subject.meshAnimalsen
dc.subject.meshAntimalarialsen
dc.subject.meshChild, Preschoolen
dc.subject.meshChloroquineen
dc.subject.meshDrug Combinationsen
dc.subject.meshDrug Resistanceen
dc.subject.meshFemaleen
dc.subject.meshHemoglobinsen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMalaria, Falciparumen
dc.subject.meshMaleen
dc.subject.meshNigeriaen
dc.subject.meshParasitemiaen
dc.subject.meshPlasmodium falciparumen
dc.subject.meshPyrimethamineen
dc.subject.meshSulfadoxineen
dc.titleEfficacy of amodiaquine in uncomplicated falciparum malaria in Nigeria in an area with high-level resistance to chloroquine and sulphadoxine/pyrimethamine.en
dc.contributor.departmentMedecins sans Frontières (MSF), Max Euweplein 40, 1001, EA, Amsterdam, The Netherlands.en
dc.identifier.journalParasitology Researchen
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