Epidemiological and clinical aspects of human Brucella suis infection in Polynesia

Hdl Handle:
http://hdl.handle.net/10144/242353
Title:
Epidemiological and clinical aspects of human Brucella suis infection in Polynesia
Authors:
Guerrier, G; Daronat, J M; Morisse, L; Yvon, J F; Pappas, G
Journal:
Epidemiology and Infection
Abstract:
High brucellosis seroprevalence rates in domestic swine herds have been reported in Wallis and Futuna Islands and are associated with a significant burden of human infection by Brucella suis, a species that is rarely incriminated in human disease. Between 2003 and 2010, seven patients had a positive blood culture for B. suis biovar 1, 11 symptomatic patients had a positive Rose Bengal test (RBT) and a positive serum agglutination test (SAT) and three asymptomatic cases were found to be positive for RBT, SAT or ELISA IgM (after systematic screening of 52 family members of 15 index cases). Overall, Brucella infection was diagnosed in 21 people, corresponding to a mean annual incidence of 19 cases/100 000 inhabitants. Compared to series of patients infected with other more commonly encountered Brucella spp. such as B. melitensis and B. abortus, clinical presentation and percentage and distribution of complications were similar, apart from a marked observation of significantly increased median alanine aminotransferase levels, 20 times greater than upper normal rates, but not accompanied by any particular hepatic pathology. Wallis and Futuna, where people live in close proximity to animals and where the cultural significance of pig-raising precludes the implementation of adequate veterinary preventive measures, thus represents one of the few known B. suis foci worldwide and allows for evaluation of the peculiarities of this infection.
Affiliation:
Epicentre, Paris, France; Agence de Santé, Mata Utu, Wallis, France; Institute of Continuing Medical Education of Ioannina, Greece; International Society of Chemotherapy Zoonoses Working Group, London, UK
Publisher:
Cambridge University Press
Issue Date:
21-Jun-2011
URI:
http://hdl.handle.net/10144/242353
DOI:
10.1017/S0950268811001075
PubMed ID:
21733252
Additional Links:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8364538
Type:
Article
Language:
en
ISSN:
1469-4409
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorGuerrier, Gen_GB
dc.contributor.authorDaronat, J Men_GB
dc.contributor.authorMorisse, Len_GB
dc.contributor.authorYvon, J Fen_GB
dc.contributor.authorPappas, Gen_GB
dc.date.accessioned2012-09-10T18:26:16Z-
dc.date.available2012-09-10T18:26:16Z-
dc.date.issued2011-06-21-
dc.identifier.citationEpidemiol Infect 2011;103:1621-1625en_GB
dc.identifier.issn1469-4409-
dc.identifier.pmid21733252-
dc.identifier.doi10.1017/S0950268811001075-
dc.identifier.urihttp://hdl.handle.net/10144/242353-
dc.description.abstractHigh brucellosis seroprevalence rates in domestic swine herds have been reported in Wallis and Futuna Islands and are associated with a significant burden of human infection by Brucella suis, a species that is rarely incriminated in human disease. Between 2003 and 2010, seven patients had a positive blood culture for B. suis biovar 1, 11 symptomatic patients had a positive Rose Bengal test (RBT) and a positive serum agglutination test (SAT) and three asymptomatic cases were found to be positive for RBT, SAT or ELISA IgM (after systematic screening of 52 family members of 15 index cases). Overall, Brucella infection was diagnosed in 21 people, corresponding to a mean annual incidence of 19 cases/100 000 inhabitants. Compared to series of patients infected with other more commonly encountered Brucella spp. such as B. melitensis and B. abortus, clinical presentation and percentage and distribution of complications were similar, apart from a marked observation of significantly increased median alanine aminotransferase levels, 20 times greater than upper normal rates, but not accompanied by any particular hepatic pathology. Wallis and Futuna, where people live in close proximity to animals and where the cultural significance of pig-raising precludes the implementation of adequate veterinary preventive measures, thus represents one of the few known B. suis foci worldwide and allows for evaluation of the peculiarities of this infection.en_GB
dc.language.isoenen
dc.publisherCambridge University Pressen_GB
dc.relation.urlhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8364538en_GB
dc.rightsArchived with thanks to Epidemiology and Infectionen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAlanine Transaminaseen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshBrucella suisen_GB
dc.subject.meshBrucellosisen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIncidenceen_GB
dc.subject.meshLiveren_GB
dc.subject.meshMaleen_GB
dc.subject.meshPolynesiaen_GB
dc.subject.meshZoonosesen_GB
dc.titleEpidemiological and clinical aspects of human Brucella suis infection in Polynesiaen
dc.typeArticleen
dc.contributor.departmentEpicentre, Paris, France; Agence de Santé, Mata Utu, Wallis, France; Institute of Continuing Medical Education of Ioannina, Greece; International Society of Chemotherapy Zoonoses Working Group, London, UKen_GB
dc.identifier.journalEpidemiology and Infectionen_GB

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