MSF Field Research > 1 Published Research and Commentary > HIV/AIDS > Adherence to HIV post-exposure prophylaxis in victims of sexual assault: a systematic review and meta-analysis

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Title: Adherence to HIV post-exposure prophylaxis in victims of sexual assault: a systematic review and meta-analysis
Authors: Chacko, Liza
Ford, Nathan
Sbaiti, Mariam
Siddiqui, Ruby
Affiliation: Imperial College London, St Mary's Hospital, London, UK; Médecins Sans Frontières, Doctors without Borders (MSF-UK), London, UK; Centre for Infectious Disease Epidemiology and Research, University of Cape Town, Cape Town, South Africa
Citation: Sex Trans Infect 2012; Published ahead of print
Publisher: BMJ Publishing Group
Journal: Sexually Transmitted Infections
Issue Date: 13-Feb-2012
URI: http://hdl.handle.net/10144/245351
DOI: 10.1136/sextrans-2011-050371
PubMed ID: 22332148
Additional Links: http://sti.bmj.com/content/early/2012/02/12/sextrans-2011-050371.short?g=w_sti_ahead_tab
Abstract: ObjectiveTo assess adherence to post-exposure prophylaxis (PEP) for the prevention of HIV infection in victims of sexual assault.MethodsThe authors carried out a systematic review, random effects meta-analysis and meta-regression of studies reporting adherence to PEP among victims of sexual violence. Seven electronic databases were searched. Our primary outcome was adherence; secondary outcomes included defaulting, refusal and side effects.Results2159 titles were screened, and 24 studies matching the inclusion criteria were taken through to analysis. The overall proportion of patients adhering to PEP (23 cohort studies, 2166 patients) was 40.3% (95% CI 32.5% to 48.1%), and the overall proportion of patients defaulting from care (18 cohorts, 1972 patients) was 41.2% (95% CI 31.1% to 51.4%). Adherence appeared to be higher in developing countries compared with developed countries.ConclusionsAdherence to PEP is poor in all settings. Interventions are needed to support adherence.
Type: Article
Language: en
MeSH: Acquired Immunodeficiency Syndrome
ISSN: 1472-3263
Rights: Published by BMJ Publishing Group Archived on this site with the kind permission of BMJ Journals
Appears in topics: HIV/AIDS

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