Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis

Hdl Handle:
http://hdl.handle.net/10144/255366
Title:
Safety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysis
Authors:
Ford, Nathan; Calmy, Alexandra; Mofenson, Lynne
Journal:
AIDS (London, England)
Abstract:
Evidence of the risk of birth defects with efavirenz use is limited. We updated a meta-analysis of birth defects in infants with first trimester efavirenz exposure up to July 2011. In 21 studies, there were 39 defects among live births in 1437 women receiving first trimester efavirenz [2.0%, 95% confidence interval (CI) 0.82-3.18]. The relative risk of defects comparing women on efavirenz-based (1290 live births) and nonefavirenz-based regimens (8122 live births) was 0.85 (95% CI 0.61-1.20). One neural tube defect was observed (myelomeningocele), giving an incidence of 0.07% (95% CI 0.002-0.39).
Affiliation:
Centre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa; Médecins Sans Frontières, Geneva, Switzerland; Geneva University Hospital, HIV Unit, Service of Infectious Diseases, Geneva, Switzerland; Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA
Publisher:
Lippincott Williams & Wilkins
Issue Date:
28-Nov-2011
URI:
http://hdl.handle.net/10144/255366
DOI:
10.1097/QAD.0b013e32834cdb71
PubMed ID:
21918421
Additional Links:
http://journals.lww.com/aidsonline/Abstract/2011/11280/Safety_of_efavirenz_in_the_first_trimester_of.13.aspx
Type:
Article
Language:
en
Description:
Article approval pending
ISSN:
1473-5571
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorFord, Nathanen_GB
dc.contributor.authorCalmy, Alexandraen_GB
dc.contributor.authorMofenson, Lynneen_GB
dc.date.accessioned2012-12-11T22:57:27Z-
dc.date.available2012-12-11T22:57:27Z-
dc.date.issued2011-11-28-
dc.identifier.citationAIDS 2011; 25(18):2301-4en_GB
dc.identifier.issn1473-5571-
dc.identifier.pmid21918421-
dc.identifier.doi10.1097/QAD.0b013e32834cdb71-
dc.identifier.urihttp://hdl.handle.net/10144/255366-
dc.descriptionArticle approval pending-
dc.description.abstractEvidence of the risk of birth defects with efavirenz use is limited. We updated a meta-analysis of birth defects in infants with first trimester efavirenz exposure up to July 2011. In 21 studies, there were 39 defects among live births in 1437 women receiving first trimester efavirenz [2.0%, 95% confidence interval (CI) 0.82-3.18]. The relative risk of defects comparing women on efavirenz-based (1290 live births) and nonefavirenz-based regimens (8122 live births) was 0.85 (95% CI 0.61-1.20). One neural tube defect was observed (myelomeningocele), giving an incidence of 0.07% (95% CI 0.002-0.39).en_GB
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen_GB
dc.relation.urlhttp://journals.lww.com/aidsonline/Abstract/2011/11280/Safety_of_efavirenz_in_the_first_trimester_of.13.aspxen_GB
dc.rightsPublished by Wolters Kluwer Lippincott Williams & Wilkins - Archived on this site by kind permission Wolters Kluweren_GB
dc.subject.meshAbnormalities, Drug-Induceden_GB
dc.subject.meshAnti-HIV Agentsen_GB
dc.subject.meshBenzoxazinesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHIV Infectionsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIncidenceen_GB
dc.subject.meshNeural Tube Defectsen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Complications, Infectiousen_GB
dc.subject.meshPregnancy Outcomeen_GB
dc.subject.meshPregnancy Trimester, Firsten_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleSafety of efavirenz in the first trimester of pregnancy: an updated systematic review and meta-analysisen
dc.typeArticleen
dc.contributor.departmentCentre for Infectious Disease Epidemiology and Research, University of Cape Town, South Africa; Médecins Sans Frontières, Geneva, Switzerland; Geneva University Hospital, HIV Unit, Service of Infectious Diseases, Geneva, Switzerland; Pediatric, Adolescent and Maternal AIDS Branch, Center for Research for Mothers and Children, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USAen_GB
dc.identifier.journalAIDS (London, England)en_GB

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