Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa

Hdl Handle:
http://hdl.handle.net/10144/255367
Title:
Time to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africa
Authors:
Lawn, Stephen D; Campbell, Lucy; Kaplan, Richard; Boulle, Andrew; Cornell, Morna; Kerschberger, Bernhard; Morrow, Carl; Little, Francesca; Egger, Matthias; Wood, Robin
Journal:
Journal of Acquired Immune Deficiency Syndromes (JAIDS)
Abstract:
We studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007-2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.
Affiliation:
The Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Department of Statistical Sciences, Faculty of Science, University of Cape Town, South Africa; School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Medecins Sans Frontieres, Cape Town, South Africa; Division of International and Environmental Health, Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerland
Publisher:
Lippincott Williams & Wilkins
Issue Date:
1-Jun-2011
URI:
http://hdl.handle.net/10144/255367
DOI:
10.1097/QAI.0b013e3182199ee9
PubMed ID:
21436714
Additional Links:
http://journals.lww.com/jaids/Abstract/2011/06010/Time_to_Initiation_of_Antiretroviral_Therapy_Among.7.aspx
Type:
Article
Language:
en
Description:
Article approval pending
ISSN:
1944-7884
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorLawn, Stephen Den_GB
dc.contributor.authorCampbell, Lucyen_GB
dc.contributor.authorKaplan, Richarden_GB
dc.contributor.authorBoulle, Andrewen_GB
dc.contributor.authorCornell, Mornaen_GB
dc.contributor.authorKerschberger, Bernharden_GB
dc.contributor.authorMorrow, Carlen_GB
dc.contributor.authorLittle, Francescaen_GB
dc.contributor.authorEgger, Matthiasen_GB
dc.contributor.authorWood, Robinen_GB
dc.date.accessioned2012-12-11T23:01:29Z-
dc.date.available2012-12-11T23:01:29Z-
dc.date.issued2011-06-01-
dc.identifier.citationJAIDS 2011; 57(2):136-40en_GB
dc.identifier.issn1944-7884-
dc.identifier.pmid21436714-
dc.identifier.doi10.1097/QAI.0b013e3182199ee9-
dc.identifier.urihttp://hdl.handle.net/10144/255367-
dc.descriptionArticle approval pending-
dc.description.abstractWe studied the time interval between starting tuberculosis treatment and commencing antiretroviral treatment (ART) in HIV-infected patients (n = 1433; median CD4 count 71 cells per microliter, interquartile range: 32-132) attending 3 South African township ART services between 2002 and 2008. The overall median delay was 2.66 months (interquartile range: 1.58-4.17). In adjusted analyses, delays varied between treatment sites but were shorter for patients with lower CD4 counts and those treated in more recent calendar years. During the most recent period (2007-2008), 4.7%, 19.7%, and 51.1% of patients started ART within 2, 4, and 8 weeks of tuberculosis treatment, respectively. Operational barriers must be tackled to permit further acceleration of ART initiation as recommended by 2010 WHO ART guidelines.en_GB
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen_GB
dc.relation.urlhttp://journals.lww.com/jaids/Abstract/2011/06010/Time_to_Initiation_of_Antiretroviral_Therapy_Among.7.aspxen_GB
dc.rightsArchived with thanks to Journal of Acquired Immune Deficiency Syndromes (JAIDS)en_GB
dc.subject.meshAIDS-Related Opportunistic Infectionsen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnti-HIV Agentsen_GB
dc.subject.meshAntitubercular Agentsen_GB
dc.subject.meshCD4 Lymphocyte Counten_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHIV Infectionsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshSouth Africaen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshTuberculosisen_GB
dc.subject.meshYoung Adulten_GB
dc.titleTime to initiation of antiretroviral therapy among patients with HIV-associated tuberculosis in Cape Town, South Africaen
dc.typeArticleen
dc.contributor.departmentThe Desmond Tutu HIV Centre, Institute for Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK; Department of Statistical Sciences, Faculty of Science, University of Cape Town, South Africa; School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Medecins Sans Frontieres, Cape Town, South Africa; Division of International and Environmental Health, Institute of Social and Preventive Medicine (ISPM), University of Bern, Switzerlanden_GB
dc.identifier.journalJournal of Acquired Immune Deficiency Syndromes (JAIDS)en_GB

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