Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options

Hdl Handle:
http://hdl.handle.net/10144/255396
Title:
Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options
Authors:
Singh, Ashika; Sunpath, Henry; Green, Taryn N; Padayachi, Nagavelli; Hiramen, Keshni; Lie, Yolanda; Anton, Elizabeth D; Murphy, Richard; Reeves, Jacqueline D; Kuritzkes, Daniel R; Ndung'u, Thumbi
Journal:
Journal of Acquired Immune Deficiency Syndromes (JAIDS)
Abstract:
Drug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell entry, either as a consequence of natural viral evolution or HAART use, may compromise the efficacy of CCR5 antagonists as alternative antiviral therapy.
Affiliation:
HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; McCord Hospital, Durban, KwaZulu-Natal, South Africa; Monogram Biosciences Inc., South San Francisco, CA, United States of America; Operational Support Unit, Doctors Without Borders, New York, USA; Section of Retroviral Therapeutics, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Boston, Massachusetts, USA
Publisher:
Lippincott Williams & Wilkins
Issue Date:
1-Nov-2011
URI:
http://hdl.handle.net/10144/255396
DOI:
10.1097/QAI.0b013e318228667f
PubMed ID:
21709569
Additional Links:
http://journals.lww.com/jaids/pages/articleviewer.aspx?year=2011&issue=11010&article=00002&type=abstract
Type:
Article
Language:
en
Description:
Article approval pending
ISSN:
1944-7884
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorSingh, Ashikaen_GB
dc.contributor.authorSunpath, Henryen_GB
dc.contributor.authorGreen, Taryn Nen_GB
dc.contributor.authorPadayachi, Nagavellien_GB
dc.contributor.authorHiramen, Keshnien_GB
dc.contributor.authorLie, Yolandaen_GB
dc.contributor.authorAnton, Elizabeth Den_GB
dc.contributor.authorMurphy, Richarden_GB
dc.contributor.authorReeves, Jacqueline Den_GB
dc.contributor.authorKuritzkes, Daniel Ren_GB
dc.contributor.authorNdung'u, Thumbien_GB
dc.date.accessioned2012-12-11T23:06:01Z-
dc.date.available2012-12-11T23:06:01Z-
dc.date.issued2011-11-01-
dc.identifier.citationJAIDS 2011; 58(3):233-240en_GB
dc.identifier.issn1944-7884-
dc.identifier.pmid21709569-
dc.identifier.doi10.1097/QAI.0b013e318228667f-
dc.identifier.urihttp://hdl.handle.net/10144/255396-
dc.descriptionArticle approval pending-
dc.description.abstractDrug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell entry, either as a consequence of natural viral evolution or HAART use, may compromise the efficacy of CCR5 antagonists as alternative antiviral therapy.en_GB
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen_GB
dc.relation.urlhttp://journals.lww.com/jaids/pages/articleviewer.aspx?year=2011&issue=11010&article=00002&type=abstracten_GB
dc.rightsArchived with thanks to Journal of Acquired Immune Deficiency Syndromes (JAIDS)en_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAnti-HIV Agentsen_GB
dc.subject.meshDrug Resistance, Viralen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGenotypeen_GB
dc.subject.meshHIV Infectionsen_GB
dc.subject.meshHIV-1en_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMutant Proteinsen_GB
dc.subject.meshMutation, Missenseen_GB
dc.subject.meshReceptors, HIVen_GB
dc.subject.meshSequence Analysis, DNAen_GB
dc.subject.meshSouth Africaen_GB
dc.subject.meshViral Tropismen_GB
dc.subject.meshpol Gene Products, Human Immunodeficiency Virusen_GB
dc.titleDrug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment optionsen
dc.typeArticleen
dc.contributor.departmentHIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; McCord Hospital, Durban, KwaZulu-Natal, South Africa; Monogram Biosciences Inc., South San Francisco, CA, United States of America; Operational Support Unit, Doctors Without Borders, New York, USA; Section of Retroviral Therapeutics, Brigham and Women's Hospital, Boston, USA; Harvard Medical School, Boston, Massachusetts, USAen_GB
dc.identifier.journalJournal of Acquired Immune Deficiency Syndromes (JAIDS)en_GB

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