Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration

Hdl Handle:
http://hdl.handle.net/10144/255412
Title:
Virologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaboration
Authors:
Davies, Mary-Ann; Moultrie, Harry; Eley, Brian; Rabie, Helena; Van Cutsem, Gilles; Giddy, Janet; Wood, Robin; Technau, Karl; Keiser, Olivia; Egger, Matthias; Boulle, Andrew
Journal:
Journal of Acquired Immune Deficiency Syndromes (JAIDS)
Abstract:
With expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic failure and switching in children in South Africa.
Affiliation:
School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; Enhancing Children's HIV Outcomes (Harriet Shezi Children's Clinic, Chris Hani Baragwanath Hospital, Soweto) and School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa; Red Cross Children's Hospital and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa; Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa; Médecins Sans Frontières, Khayelitsha, South Africa and Khayelitsha ART Programme; McCord Hospital, Durban, South Africa; Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Empilweni Service and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Publisher:
Lippincott Williams & Wilkins
Issue Date:
1-Mar-2011
URI:
http://hdl.handle.net/10144/255412
DOI:
10.1097/QAI.0b013e3182060610
PubMed ID:
21107266
Additional Links:
http://journals.lww.com/jaids/Abstract/2011/03010/Virologic_Failure_and_Second_Line_Antiretroviral.13.aspx
Type:
Article
Language:
en
Description:
Article approval pending
ISSN:
1944-7884
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorDavies, Mary-Annen
dc.contributor.authorMoultrie, Harryen
dc.contributor.authorEley, Brianen
dc.contributor.authorRabie, Helenaen
dc.contributor.authorVan Cutsem, Gillesen
dc.contributor.authorGiddy, Janeten
dc.contributor.authorWood, Robinen
dc.contributor.authorTechnau, Karlen
dc.contributor.authorKeiser, Oliviaen
dc.contributor.authorEgger, Matthiasen
dc.contributor.authorBoulle, Andrewen
dc.date.accessioned2012-12-11T23:46:39Z-
dc.date.available2012-12-11T23:46:39Z-
dc.date.issued2011-03-01-
dc.identifier.citationJAIDS 2011; 56(3):270-8en
dc.identifier.issn1944-7884-
dc.identifier.pmid21107266-
dc.identifier.doi10.1097/QAI.0b013e3182060610-
dc.identifier.urihttp://hdl.handle.net/10144/255412-
dc.descriptionArticle approval pending-
dc.description.abstractWith expanding pediatric antiretroviral therapy (ART) access, children will begin to experience treatment failure and require second-line therapy. We evaluated the probability and determinants of virologic failure and switching in children in South Africa.en
dc.language.isoenen
dc.publisherLippincott Williams & Wilkinsen
dc.relation.urlhttp://journals.lww.com/jaids/Abstract/2011/03010/Virologic_Failure_and_Second_Line_Antiretroviral.13.aspxen
dc.rightsArchived with thanks to Journal of Acquired Immune Deficiency Syndromes (JAIDS)en
dc.subject.meshAnti-HIV Agentsen
dc.subject.meshAntiretroviral Therapy, Highly Activeen
dc.subject.meshCD4 Lymphocyte Counten
dc.subject.meshChilden
dc.subject.meshChild, Preschoolen
dc.subject.meshDrug Monitoringen
dc.subject.meshFemaleen
dc.subject.meshHIV Infectionsen
dc.subject.meshHumansen
dc.subject.meshInfanten
dc.subject.meshMaleen
dc.subject.meshNevirapineen
dc.subject.meshPregnancyen
dc.subject.meshRitonaviren
dc.subject.meshSalvage Therapyen
dc.subject.meshSouth Africaen
dc.subject.meshTreatment Failureen
dc.subject.meshViral Loaden
dc.titleVirologic failure and second-line antiretroviral therapy in children in South Africa--the IeDEA Southern Africa collaborationen
dc.typeArticleen
dc.contributor.departmentSchool of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa; Enhancing Children's HIV Outcomes (Harriet Shezi Children's Clinic, Chris Hani Baragwanath Hospital, Soweto) and School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa; Red Cross Children's Hospital and School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa; Tygerberg Academic Hospital, University of Stellenbosch, Stellenbosch, South Africa; Médecins Sans Frontières, Khayelitsha, South Africa and Khayelitsha ART Programme; McCord Hospital, Durban, South Africa; Gugulethu Community Health Centre and Desmond Tutu HIV Centre, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa; Empilweni Service and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand, Johannesburg, South Africa; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerlanden
dc.identifier.journalJournal of Acquired Immune Deficiency Syndromes (JAIDS)en

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