Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.

Hdl Handle:
http://hdl.handle.net/10144/270872
Title:
Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.
Authors:
McNerney, R; Maeurer, M; Abubakar, I; Marais, B; McHugh, T D; Ford, N; Weyer, K; Lawn, S; Grobusch, M P; Memish, Z; Squire, S B; Pantaleo, G; Chakaya, J; Casenghi, M; Migliori, G-B; Mwaba, P; Zijenah, L; Hoelscher, M; Cox, H; Swaminathan, S; Kim, P S; Schito, M; Harari, A; Bates, M; Schwank, S; O'Grady, J; Pletschette, M; Ditui, L; Atun, R; Zumla, A
Journal:
Journal of Infectious Diseases
Abstract:
Tuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary tuberculosis in a timely fashion, allowing continued Mycobacterium tuberculosis transmission within communities. Currently recommended gold-standard diagnostic tests for tuberculosis are laboratory based, and multiple investigations may be necessary over a period of weeks or months before a diagnosis is made. Several new diagnostic tests have recently become available for detecting active tuberculosis disease, screening for latent M. tuberculosis infection, and identifying drug-resistant strains of M. tuberculosis. However, progress toward a robust point-of-care test has been limited, and novel biomarker discovery remains challenging. In the absence of effective prevention strategies, high rates of early case detection and subsequent cure are required for global tuberculosis control. Early case detection is dependent on test accuracy, accessibility, cost, and complexity, but also depends on the political will and funder investment to deliver optimal, sustainable care to those worst affected by the tuberculosis and human immunodeficiency virus epidemics. This review highlights unanswered questions, challenges, recent advances, unresolved operational and technical issues, needs, and opportunities related to tuberculosis diagnostics.
Affiliation:
Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.
Issue Date:
15-May-2012
URI:
http://hdl.handle.net/10144/270872
DOI:
10.1093/infdis/jir860
PubMed ID:
22496353
Language:
en
ISSN:
1537-6613
Appears in Collections:
TB

Full metadata record

DC FieldValue Language
dc.contributor.authorMcNerney, Ren_GB
dc.contributor.authorMaeurer, Men_GB
dc.contributor.authorAbubakar, Ien_GB
dc.contributor.authorMarais, Ben_GB
dc.contributor.authorMcHugh, T Den_GB
dc.contributor.authorFord, Nen_GB
dc.contributor.authorWeyer, Ken_GB
dc.contributor.authorLawn, Sen_GB
dc.contributor.authorGrobusch, M Pen_GB
dc.contributor.authorMemish, Zen_GB
dc.contributor.authorSquire, S Ben_GB
dc.contributor.authorPantaleo, Gen_GB
dc.contributor.authorChakaya, Jen_GB
dc.contributor.authorCasenghi, Men_GB
dc.contributor.authorMigliori, G-Ben_GB
dc.contributor.authorMwaba, Pen_GB
dc.contributor.authorZijenah, Len_GB
dc.contributor.authorHoelscher, Men_GB
dc.contributor.authorCox, Hen_GB
dc.contributor.authorSwaminathan, Sen_GB
dc.contributor.authorKim, P Sen_GB
dc.contributor.authorSchito, Men_GB
dc.contributor.authorHarari, Aen_GB
dc.contributor.authorBates, Men_GB
dc.contributor.authorSchwank, Sen_GB
dc.contributor.authorO'Grady, Jen_GB
dc.contributor.authorPletschette, Men_GB
dc.contributor.authorDitui, Len_GB
dc.contributor.authorAtun, Ren_GB
dc.contributor.authorZumla, Aen_GB
dc.date.accessioned2013-03-03T17:02:47Z-
dc.date.available2013-03-03T17:02:47Z-
dc.date.issued2012-05-15-
dc.identifier.citationTuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities. 2012, 205 Suppl 2:S147-58 J. Infect. Dis.en_GB
dc.identifier.issn1537-6613-
dc.identifier.pmid22496353-
dc.identifier.doi10.1093/infdis/jir860-
dc.identifier.urihttp://hdl.handle.net/10144/270872-
dc.description.abstractTuberculosis is unique among the major infectious diseases in that it lacks accurate rapid point-of-care diagnostic tests. Failure to control the spread of tuberculosis is largely due to our inability to detect and treat all infectious cases of pulmonary tuberculosis in a timely fashion, allowing continued Mycobacterium tuberculosis transmission within communities. Currently recommended gold-standard diagnostic tests for tuberculosis are laboratory based, and multiple investigations may be necessary over a period of weeks or months before a diagnosis is made. Several new diagnostic tests have recently become available for detecting active tuberculosis disease, screening for latent M. tuberculosis infection, and identifying drug-resistant strains of M. tuberculosis. However, progress toward a robust point-of-care test has been limited, and novel biomarker discovery remains challenging. In the absence of effective prevention strategies, high rates of early case detection and subsequent cure are required for global tuberculosis control. Early case detection is dependent on test accuracy, accessibility, cost, and complexity, but also depends on the political will and funder investment to deliver optimal, sustainable care to those worst affected by the tuberculosis and human immunodeficiency virus epidemics. This review highlights unanswered questions, challenges, recent advances, unresolved operational and technical issues, needs, and opportunities related to tuberculosis diagnostics.en_GB
dc.language.isoenen
dc.rightsPublished by Infectious Diseases Society of America Archived on this site with permission and copyright 2012 by the Infectious Diseases Society of America, [url] and Oxford University Pressen_GB
dc.subject.meshAntitubercular Agentsen_GB
dc.subject.meshBacteriological Techniquesen_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshDrug Resistance, Bacterialen_GB
dc.subject.meshHumansen_GB
dc.subject.meshTuberculosisen_GB
dc.titleTuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities.en
dc.contributor.departmentDepartment of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, United Kingdom.en_GB
dc.identifier.journalJournal of Infectious Diseasesen_GB

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