In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness

Hdl Handle:
http://hdl.handle.net/10144/272002
Title:
In-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sickness
Authors:
Schmid, Caecilia; Kuemmerle, Andrea; Blum, Johannes; Ghabri, Salah; Kande, Victor; Mutombo, Wilfried; Ilunga, Medard; Lumpungu, Ismael; Mutanda, Sylvain; Nganzobo, Pathou; Tete, Digas; Mubwa, Nono; Kisala, Mays; Blesson, Severine; Mordt, Olaf Valverde
Journal:
PLoS Neglected Tropical Diseases
Abstract:
Trypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and insufficiently effective in certain areas (melarsoprol). Recently, nifurtimox-eflornithine combination therapy (NECT) demonstrated good safety and efficacy in a randomised controlled trial (RCT) and was added to the World Health Organisation (WHO) essential medicines list (EML). Documentation of its safety profile in field conditions will support its wider use.
Affiliation:
Department of Medicines Research, Swiss Tropical and Public Health Institute, Basel, Switzerland.
Issue Date:
29-Nov-2012
URI:
http://hdl.handle.net/10144/272002
DOI:
10.1371/journal.pntd.0001920
PubMed ID:
23209861
Language:
en
ISSN:
1935-2735
Appears in Collections:
Trypanosomiasis/Sleeping Sickness

Full metadata record

DC FieldValue Language
dc.contributor.authorSchmid, Caeciliaen_GB
dc.contributor.authorKuemmerle, Andreaen_GB
dc.contributor.authorBlum, Johannesen_GB
dc.contributor.authorGhabri, Salahen_GB
dc.contributor.authorKande, Victoren_GB
dc.contributor.authorMutombo, Wilfrieden_GB
dc.contributor.authorIlunga, Medarden_GB
dc.contributor.authorLumpungu, Ismaelen_GB
dc.contributor.authorMutanda, Sylvainen_GB
dc.contributor.authorNganzobo, Pathouen_GB
dc.contributor.authorTete, Digasen_GB
dc.contributor.authorMubwa, Nonoen_GB
dc.contributor.authorKisala, Maysen_GB
dc.contributor.authorBlesson, Severineen_GB
dc.contributor.authorMordt, Olaf Valverdeen_GB
dc.date.accessioned2013-03-13T12:20:12Z-
dc.date.available2013-03-13T12:20:12Z-
dc.date.issued2012-11-29-
dc.identifier.citationIn-hospital safety in field conditions of nifurtimox eflornithine combination therapy (NECT) for T. b. gambiense sleeping sickness. 2012, 6 (11):e1920 PLoS Negl Trop Disen_GB
dc.identifier.issn1935-2735-
dc.identifier.pmid23209861-
dc.identifier.doi10.1371/journal.pntd.0001920-
dc.identifier.urihttp://hdl.handle.net/10144/272002-
dc.description.abstractTrypanosoma brucei (T.b.) gambiense Human African trypanosomiasis (HAT; sleeping sickness) is a fatal disease. Until 2009, available treatments for 2(nd) stage HAT were complicated to use, expensive (eflornithine monotherapy), or toxic, and insufficiently effective in certain areas (melarsoprol). Recently, nifurtimox-eflornithine combination therapy (NECT) demonstrated good safety and efficacy in a randomised controlled trial (RCT) and was added to the World Health Organisation (WHO) essential medicines list (EML). Documentation of its safety profile in field conditions will support its wider use.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PLoS Neglected Tropical Diseases and Open Accessen_GB
dc.titleIn-hospital safety in field conditions of Nifurtimox Eflornithine Combination Therapy (NECT) for T. B. Gambiense Sleeping Sicknessen
dc.contributor.departmentDepartment of Medicines Research, Swiss Tropical and Public Health Institute, Basel, Switzerland.en_GB
dc.identifier.journalPLoS Neglected Tropical Diseasesen_GB

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