Glucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malaria

Hdl Handle:
http://hdl.handle.net/10144/272004
Title:
Glucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malaria
Authors:
Van Malderen, Carine; Van Geertruyden, Jean-Pierre; Machevo, Sonia; González, Raquel; Bassat, Quique; Talisuna, Ambrose; Yeka, Adoke; Nabasumba, Carolyn; Piola, Patrice; Daniel, Atwine; Turyakira, Eleanor; Forret, Pascale; Van Overmeir, Chantal; van Loen, Harry; Robert, Annie; D' Alessandro, Umberto
Journal:
Malaria Journal
Abstract:
Malaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely stopped because of safety concerns secondary to its associated risk of haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The objective of the study was to assess whether CDA treatment and G6PD deficiency are risk factors for a post-treatment haemoglobin drop in African children<5 years of age with uncomplicated malaria.
Affiliation:
Faculté de pharmacie et des sciences biomédicales, Université catholique de Louvain, Brussels, Belgium. carine.vanmalderen@uclouvain.be
Issue Date:
30-Apr-2012
URI:
http://hdl.handle.net/10144/272004
DOI:
10.1186/1475-2875-11-139
PubMed ID:
22546009
Language:
en
ISSN:
1475-2875
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorVan Malderen, Carineen_GB
dc.contributor.authorVan Geertruyden, Jean-Pierreen_GB
dc.contributor.authorMachevo, Soniaen_GB
dc.contributor.authorGonzález, Raquelen_GB
dc.contributor.authorBassat, Quiqueen_GB
dc.contributor.authorTalisuna, Ambroseen_GB
dc.contributor.authorYeka, Adokeen_GB
dc.contributor.authorNabasumba, Carolynen_GB
dc.contributor.authorPiola, Patriceen_GB
dc.contributor.authorDaniel, Atwineen_GB
dc.contributor.authorTuryakira, Eleanoren_GB
dc.contributor.authorForret, Pascaleen_GB
dc.contributor.authorVan Overmeir, Chantalen_GB
dc.contributor.authorvan Loen, Harryen_GB
dc.contributor.authorRobert, Annieen_GB
dc.contributor.authorD' Alessandro, Umbertoen_GB
dc.date.accessioned2013-03-13T12:28:09Z-
dc.date.available2013-03-13T12:28:09Z-
dc.date.issued2012-04-30-
dc.identifier.citationGlucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria. 2012, 11:139 Malar. J.en_GB
dc.identifier.issn1475-2875-
dc.identifier.pmid22546009-
dc.identifier.doi10.1186/1475-2875-11-139-
dc.identifier.urihttp://hdl.handle.net/10144/272004-
dc.description.abstractMalaria is a leading cause of mortality, particularly in sub-Saharan African children. Prompt and efficacious treatment is important as patients may progress within a few hours to severe and possibly fatal disease. Chlorproguanil-dapsone-artesunate (CDA) was a promising artemisinin-based combination therapy (ACT), but its development was prematurely stopped because of safety concerns secondary to its associated risk of haemolytic anaemia in glucose-6-phosphate dehydrogenase (G6PD)-deficient individuals. The objective of the study was to assess whether CDA treatment and G6PD deficiency are risk factors for a post-treatment haemoglobin drop in African children<5 years of age with uncomplicated malaria.en_GB
dc.language.isoenen
dc.rightsPublished by BioMed Central, [url]http://www.malariajournal.com/[/url] Archived on this site by Open Access permissionen_GB
dc.subject.meshAfrica South of the Saharaen_GB
dc.subject.meshAnemia, Hemolyticen_GB
dc.subject.meshAntimalarialsen_GB
dc.subject.meshArtemisininsen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshChild, Preschoolen_GB
dc.subject.meshDapsoneen_GB
dc.subject.meshDrug Combinationsen_GB
dc.subject.meshDrug Therapy, Combinationen_GB
dc.subject.meshGlucosephosphate Dehydrogenase Deficiencyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfanten_GB
dc.subject.meshMalariaen_GB
dc.subject.meshMaleen_GB
dc.subject.meshProguanilen_GB
dc.titleGlucose-6-Phosphate Dehydrogenase Deficiency, Chlorproguanil-Dapsone with Artesunate and Post-treatment Haemolysis in African children treated for uncomplicated Malariaen
dc.contributor.departmentFaculté de pharmacie et des sciences biomédicales, Université catholique de Louvain, Brussels, Belgium. carine.vanmalderen@uclouvain.been_GB
dc.identifier.journalMalaria Journalen_GB

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