Artemether-Lumefantrine to treat Malaria in pregnancy is associated with reduced placental Haemozoin deposition compared to Quinine in a randomized controlled trial

Hdl Handle:
http://hdl.handle.net/10144/272006
Title:
Artemether-Lumefantrine to treat Malaria in pregnancy is associated with reduced placental Haemozoin deposition compared to Quinine in a randomized controlled trial
Authors:
Muehlenbachs, Atis; Nabasumba, Carolyn; McGready, Rose; Turyakira, Eleanor; Tumwebaze, Benon; Dhorda, Mehul; Nyehangane, Dan; Nalusaji, Aisha; Nosten, Franois; Guerin, Philippe J; Piola, Patrice
Journal:
Malaria Journal
Abstract:
Data on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda demonstrated that artemether-lumefantrine (AL) is not inferior to quinine to treat uncomplicated malaria in pregnancy. Haemozoin can persist in the placenta following clearance of parasites, however there is no data whether ACT can influence the amount of haemozoin or the dynamics of haemozoin clearance.
Affiliation:
Department of Pathology, University of Washington, Box 357470, 1959 NE Pacific Street, Seattle, WA, USA. amuehlen@u.washington.edu
Issue Date:
3-May-2012
URI:
http://hdl.handle.net/10144/272006
DOI:
10.1186/1475-2875-11-150
PubMed ID:
22554092
Language:
en
ISSN:
1475-2875
Appears in Collections:
Malaria

Full metadata record

DC FieldValue Language
dc.contributor.authorMuehlenbachs, Atisen_GB
dc.contributor.authorNabasumba, Carolynen_GB
dc.contributor.authorMcGready, Roseen_GB
dc.contributor.authorTuryakira, Eleanoren_GB
dc.contributor.authorTumwebaze, Benonen_GB
dc.contributor.authorDhorda, Mehulen_GB
dc.contributor.authorNyehangane, Danen_GB
dc.contributor.authorNalusaji, Aishaen_GB
dc.contributor.authorNosten, Franoisen_GB
dc.contributor.authorGuerin, Philippe Jen_GB
dc.contributor.authorPiola, Patriceen_GB
dc.date.accessioned2013-03-13T12:31:42Z-
dc.date.available2013-03-13T12:31:42Z-
dc.date.issued2012-05-03-
dc.identifier.citationArtemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial. 2012, 11:150 Malar. J.en_GB
dc.identifier.issn1475-2875-
dc.identifier.pmid22554092-
dc.identifier.doi10.1186/1475-2875-11-150-
dc.identifier.urihttp://hdl.handle.net/10144/272006-
dc.description.abstractData on efficacy of artemisinin-based combination therapy (ACT) to treat Plasmodium falciparum during pregnancy in sub-Saharan Africa is scarce. A recent open label, randomized controlled trial in Mbarara, Uganda demonstrated that artemether-lumefantrine (AL) is not inferior to quinine to treat uncomplicated malaria in pregnancy. Haemozoin can persist in the placenta following clearance of parasites, however there is no data whether ACT can influence the amount of haemozoin or the dynamics of haemozoin clearance.en_GB
dc.language.isoenen
dc.rightsPublished by BioMed Central, [url]http://www.malariajournal.com/[/url] Archived on this site by Open Access permissionen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAntimalarialsen_GB
dc.subject.meshArtemisininsen_GB
dc.subject.meshDrug Combinationsen_GB
dc.subject.meshEthanolaminesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFluorenesen_GB
dc.subject.meshHemeproteinsen_GB
dc.subject.meshHistocytochemistryen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshMalaria, Falciparumen_GB
dc.subject.meshPlacentaen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Complications, Infectiousen_GB
dc.subject.meshQuinineen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.subject.meshUgandaen_GB
dc.subject.meshYoung Adulten_GB
dc.titleArtemether-Lumefantrine to treat Malaria in pregnancy is associated with reduced placental Haemozoin deposition compared to Quinine in a randomized controlled trialen
dc.contributor.departmentDepartment of Pathology, University of Washington, Box 357470, 1959 NE Pacific Street, Seattle, WA, USA. amuehlen@u.washington.eduen_GB
dc.identifier.journalMalaria Journalen_GB

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