Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008

Hdl Handle:
http://hdl.handle.net/10144/278973
Title:
Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008
Authors:
Roddy, Paul; Howard, Natasha; Van Kerkhove, Maria D; Lutwama, Julius; Wamala, Joseph; Yoti, Zabulon; Colebunders, Robert; Palma, Pedro Pablo; Sterk, Esther; Jeffs, Benjamin; Van Herp, Michel; Borchert, Matthias
Journal:
PloS One
Abstract:
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect.
Affiliation:
Medical Departments of Médecins Sans Frontières, Barcelona, Spain. roddypd@gmail.com
Issue Date:
28-Dec-2012
URI:
http://hdl.handle.net/10144/278973
DOI:
10.1371/journal.pone.0052986
PubMed ID:
23285243
Language:
en
ISSN:
1932-6203
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorRoddy, Paulen_GB
dc.contributor.authorHoward, Natashaen_GB
dc.contributor.authorVan Kerkhove, Maria Den_GB
dc.contributor.authorLutwama, Juliusen_GB
dc.contributor.authorWamala, Josephen_GB
dc.contributor.authorYoti, Zabulonen_GB
dc.contributor.authorColebunders, Roberten_GB
dc.contributor.authorPalma, Pedro Pabloen_GB
dc.contributor.authorSterk, Estheren_GB
dc.contributor.authorJeffs, Benjaminen_GB
dc.contributor.authorVan Herp, Michelen_GB
dc.contributor.authorBorchert, Matthiasen_GB
dc.date.accessioned2013-04-04T20:41:05Z-
dc.date.available2013-04-04T20:41:05Z-
dc.date.issued2012-12-28-
dc.identifier.citationClinical manifestations and case management of Ebola haemorrhagic fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008. 2012, 7 (12):e52986 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid23285243-
dc.identifier.doi10.1371/journal.pone.0052986-
dc.identifier.urihttp://hdl.handle.net/10144/278973-
dc.description.abstractA confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect.en_GB
dc.language.isoenen
dc.rightsPublished by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permissionen_GB
dc.titleClinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008en
dc.contributor.departmentMedical Departments of Médecins Sans Frontières, Barcelona, Spain. roddypd@gmail.comen_GB
dc.identifier.journalPloS Oneen_GB

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