Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy.

Hdl Handle:
http://hdl.handle.net/10144/28617
Title:
Selenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy.
Authors:
Moreno-Reyes, R; Mathieu, F; Boelaert, M; Begaux, F; Suetens, C; Rivera, M; Nève, J; Perlmutter, N; Vanderpas, J
Journal:
The American Journal of Clinical Nutrition
Abstract:
BACKGROUND: Kashin-Beck disease is an osteoarthropathy endemic in selenium- and iodine-deficient areas around Lhasa, Tibet. OBJECTIVE: We assessed the efficacy of selenium supplementation on disease progression. DESIGN: A double-blind, randomized controlled trial of selenium supplementation was carried out in 324 children aged 5-15 y who had Kashin-Beck disease. Two hundred eighty children received iodized oil before being randomly assigned to receive selenium or placebo, and a control group of 44 subjects was not supplemented at all. Clinical and radiologic signs, selenium status, urinary iodine, and thyroid function were evaluated at baseline and at 12 mo. RESULTS: The frequencies of joint pain, decreased joint mobility, and radiologic abnormalities were not significantly different between the 3 groups at 12 mo. Height-for-age z scores increased significantly in the subjects who received placebo and iodine or selenium and iodine. In contrast, unsupplemented control subjects did not recover from growth retardation. Serum selenium concentrations at 12 mo were within the reference range and were significantly greater in the selenium-iodine group than in the placebo-iodine group. Serum thyroid hormone concentrations were within the reference ranges after the administration of iodine, and these values were not significantly affected by selenium supplementation. CONCLUSIONS: The results of this study do not rule out the possibility that selenium may help to prevent the occurrence of Kashin-Beck disease. However, selenium supplementation had no effect on established Kashin-Beck disease, growth, or thyroid function once iodine deficiency was corrected. These results suggest that iodine, but not selenium, deficiency should be corrected in Tibetan children with Kashin-Beck disease.
Affiliation:
Department of Nuclear Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.be
Issue Date:
Jul-2003
URI:
http://hdl.handle.net/10144/28617
PubMed ID:
12816783
Language:
en
ISSN:
0002-9165
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorMoreno-Reyes, R-
dc.contributor.authorMathieu, F-
dc.contributor.authorBoelaert, M-
dc.contributor.authorBegaux, F-
dc.contributor.authorSuetens, C-
dc.contributor.authorRivera, M-
dc.contributor.authorNève, J-
dc.contributor.authorPerlmutter, N-
dc.contributor.authorVanderpas, J-
dc.date.accessioned2008-05-28T13:54:24Z-
dc.date.available2008-05-28T13:54:24Z-
dc.date.issued2003-07-
dc.identifier.citationSelenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy. 2003, 78 (1):137-44 Am. J. Clin. Nutr.en
dc.identifier.issn0002-9165-
dc.identifier.pmid12816783-
dc.identifier.urihttp://hdl.handle.net/10144/28617-
dc.description.abstractBACKGROUND: Kashin-Beck disease is an osteoarthropathy endemic in selenium- and iodine-deficient areas around Lhasa, Tibet. OBJECTIVE: We assessed the efficacy of selenium supplementation on disease progression. DESIGN: A double-blind, randomized controlled trial of selenium supplementation was carried out in 324 children aged 5-15 y who had Kashin-Beck disease. Two hundred eighty children received iodized oil before being randomly assigned to receive selenium or placebo, and a control group of 44 subjects was not supplemented at all. Clinical and radiologic signs, selenium status, urinary iodine, and thyroid function were evaluated at baseline and at 12 mo. RESULTS: The frequencies of joint pain, decreased joint mobility, and radiologic abnormalities were not significantly different between the 3 groups at 12 mo. Height-for-age z scores increased significantly in the subjects who received placebo and iodine or selenium and iodine. In contrast, unsupplemented control subjects did not recover from growth retardation. Serum selenium concentrations at 12 mo were within the reference range and were significantly greater in the selenium-iodine group than in the placebo-iodine group. Serum thyroid hormone concentrations were within the reference ranges after the administration of iodine, and these values were not significantly affected by selenium supplementation. CONCLUSIONS: The results of this study do not rule out the possibility that selenium may help to prevent the occurrence of Kashin-Beck disease. However, selenium supplementation had no effect on established Kashin-Beck disease, growth, or thyroid function once iodine deficiency was corrected. These results suggest that iodine, but not selenium, deficiency should be corrected in Tibetan children with Kashin-Beck disease.en
dc.language.isoenen
dc.rightsArchived with thanks to The American Journal of Clinical Nutritionen
dc.subject.meshAdolescenten
dc.subject.meshChilden
dc.subject.meshDietary Supplementsen
dc.subject.meshDouble-Blind Methoden
dc.subject.meshDrug Therapy, Combinationen
dc.subject.meshEndemic Diseasesen
dc.subject.meshFemaleen
dc.subject.meshGrowth Disordersen
dc.subject.meshHumansen
dc.subject.meshIodineen
dc.subject.meshMaleen
dc.subject.meshOsteoarthritisen
dc.subject.meshRural Populationen
dc.subject.meshSeleniumen
dc.subject.meshThyroid Hormonesen
dc.subject.meshTibeten
dc.subject.meshTreatment Outcomeen
dc.titleSelenium and iodine supplementation of rural Tibetan children affected by Kashin-Beck osteoarthropathy.en
dc.contributor.departmentDepartment of Nuclear Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.been
dc.identifier.journalThe American Journal of Clinical Nutritionen

Related articles on PubMed

All Items in MSF are protected by copyright, with all rights reserved, unless otherwise indicated.