Kashin-Beck disease and iodine deficiency in Tibet.

Hdl Handle:
http://hdl.handle.net/10144/28678
Title:
Kashin-Beck disease and iodine deficiency in Tibet.
Authors:
Moreno-Reyes, R; Suetens, C; Mathieu, F; Begaux, F; Zhu, D; Rivera, M; Boelaert, M; Nève, J; Perlmutter, N; Vanderpas, J
Journal:
International Orthopaedics
Abstract:
We evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.
Affiliation:
Department of Nuclear Medicine, Hĵpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.be
Issue Date:
2001
URI:
http://hdl.handle.net/10144/28678
PubMed ID:
11482533
Language:
en
ISSN:
0341-2695
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorMoreno-Reyes, R-
dc.contributor.authorSuetens, C-
dc.contributor.authorMathieu, F-
dc.contributor.authorBegaux, F-
dc.contributor.authorZhu, D-
dc.contributor.authorRivera, M-
dc.contributor.authorBoelaert, M-
dc.contributor.authorNève, J-
dc.contributor.authorPerlmutter, N-
dc.contributor.authorVanderpas, J-
dc.date.accessioned2008-05-28T13:53:01Z-
dc.date.available2008-05-28T13:53:01Z-
dc.date.issued2001-
dc.identifier.citationKashin-Beck disease and iodine deficiency in Tibet. 2001, 25 (3):164-6notInt Orthopen
dc.identifier.issn0341-2695-
dc.identifier.pmid11482533-
dc.identifier.urihttp://hdl.handle.net/10144/28678-
dc.description.abstractWe evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.en
dc.language.isoenen
dc.rightsArchived on this site with kind permission of Springer Science+Business Mediaen
dc.subject.meshAdolescenten
dc.subject.meshChilden
dc.subject.meshFemaleen
dc.subject.meshHumansen
dc.subject.meshIodineen
dc.subject.meshMaleen
dc.subject.meshOsteoarthritisen
dc.subject.meshRisk Factorsen
dc.subject.meshSeleniumen
dc.subject.meshTibeten
dc.titleKashin-Beck disease and iodine deficiency in Tibet.en
dc.contributor.departmentDepartment of Nuclear Medicine, Hĵpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.been
dc.identifier.journalInternational Orthopaedicsen

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