Rapid Diagnostic Tests for Non-Malarial Febrile Illness in the Tropics

Hdl Handle:
http://hdl.handle.net/10144/302774
Title:
Rapid Diagnostic Tests for Non-Malarial Febrile Illness in the Tropics
Authors:
Chappuis, F; Alirol, E; d'Acremont, V; Bottieau, E; Yansouni, C P
Journal:
Clinical Microbiology and Infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Abstract:
The recent roll-out of rapid diagnostic tests (RDTs) for malaria has highlighted the decreasing proportion of malaria-attributable illness in endemic areas. Unfortunately, once malaria is excluded, there are few accessible diagnostic tools to guide the management of severe febrile illnesses in low resource settings. This review summarizes the current state of RDT development for several key infections, including dengue fever, enteric fever, leptospirosis, brucellosis, visceral leishmaniasis and human African trypanosomiasis, and highlights many remaining gaps. Most RDTs for non-malarial tropical infections currently rely on the detection of host antibodies against a single infectious agent. The sensitivity and specificity of host-antibody detection tests are both inherently limited. Moreover, prolonged antibody responses to many infections preclude the use of most serological RDTs for monitoring response to treatment and/or for diagnosing relapse. Considering these limitations, there is a pressing need for sensitive pathogen-detection-based RDTs, as have been successfully developed for malaria and dengue. Ultimately, integration of RDTs into a validated syndromic approach to tropical fevers is urgently needed. Related research priorities are to define the evolving epidemiology of fever in the tropics, and to determine how combinations of RDTs could be best used to improve the management of severe and treatable infections requiring specific therapy.
Affiliation:
Division of International and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland; Médecins Sans Frontières, Operational Centre Geneva, Geneva, Switzerland.
Issue Date:
15-Feb-2013
URI:
http://hdl.handle.net/10144/302774
DOI:
10.1111/1469-0691.12154
PubMed ID:
23413992
Language:
en
ISSN:
1469-0691
Appears in Collections:
Laboratory

Full metadata record

DC FieldValue Language
dc.contributor.authorChappuis, Fen_GB
dc.contributor.authorAlirol, Een_GB
dc.contributor.authord'Acremont, Ven_GB
dc.contributor.authorBottieau, Een_GB
dc.contributor.authorYansouni, C Pen_GB
dc.date.accessioned2013-10-05T14:32:58Z-
dc.date.available2013-10-05T14:32:58Z-
dc.date.issued2013-02-15-
dc.identifier.citationRapid diagnostic tests for non-malarial febrile illness in the tropics. 2013: Clin. Microbiol. Infect.en_GB
dc.identifier.issn1469-0691-
dc.identifier.pmid23413992-
dc.identifier.doi10.1111/1469-0691.12154-
dc.identifier.urihttp://hdl.handle.net/10144/302774-
dc.description.abstractThe recent roll-out of rapid diagnostic tests (RDTs) for malaria has highlighted the decreasing proportion of malaria-attributable illness in endemic areas. Unfortunately, once malaria is excluded, there are few accessible diagnostic tools to guide the management of severe febrile illnesses in low resource settings. This review summarizes the current state of RDT development for several key infections, including dengue fever, enteric fever, leptospirosis, brucellosis, visceral leishmaniasis and human African trypanosomiasis, and highlights many remaining gaps. Most RDTs for non-malarial tropical infections currently rely on the detection of host antibodies against a single infectious agent. The sensitivity and specificity of host-antibody detection tests are both inherently limited. Moreover, prolonged antibody responses to many infections preclude the use of most serological RDTs for monitoring response to treatment and/or for diagnosing relapse. Considering these limitations, there is a pressing need for sensitive pathogen-detection-based RDTs, as have been successfully developed for malaria and dengue. Ultimately, integration of RDTs into a validated syndromic approach to tropical fevers is urgently needed. Related research priorities are to define the evolving epidemiology of fever in the tropics, and to determine how combinations of RDTs could be best used to improve the management of severe and treatable infections requiring specific therapy.en_GB
dc.languageENG-
dc.language.isoenen
dc.rightsAwaiting publisher's approvalen_GB
dc.titleRapid Diagnostic Tests for Non-Malarial Febrile Illness in the Tropicsen
dc.contributor.departmentDivision of International and Humanitarian Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland; Médecins Sans Frontières, Operational Centre Geneva, Geneva, Switzerland.en_GB
dc.identifier.journalClinical Microbiology and Infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseasesen_GB

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