Nifurtimox-Eflornithine Combination Therapy for Second-stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo

Hdl Handle:
http://hdl.handle.net/10144/303511
Title:
Nifurtimox-Eflornithine Combination Therapy for Second-stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo
Authors:
Alirol, Emilie; Schrumpf, David; Amici Heradi, Josué; Riedel, Andrea; de Patoul, Catherine; Quere, Michel; Chappuis, François
Journal:
Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America
Abstract:
Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of nifurtimox-eflornithine combination therapy (NECT) has brought new hopes for patients in the second stage. While NECT has been rolled out in most endemic countries, safety data are scarce and derive only from clinical trials. The World Health Organization (WHO) coordinates a pharmacovigilance program to collect additional data on NECT safety and efficacy. We report here the results of 18 months of experience of NECT use in treatment centers run by Médecins Sans Frontières in the Democratic Republic of the Congo (DRC).
Affiliation:
Division of International and Humanitarian Medicine, University Hospitals of Geneva, Switzerland. emilie.alirol@hcuge.ch
Publisher:
Oxford University Press
Issue Date:
9-Nov-2012
URI:
http://hdl.handle.net/10144/303511
DOI:
10.1093/cid/cis886
PubMed ID:
23074318
Additional Links:
http://cid.oxfordjournals.org//cgi/reprint/56/2/195?ijkey=n6iCHos9f2/bE&keytype=ref&siteid=cid
Language:
en
Description:
To access this article, click on "Additional Links"
ISSN:
1537-6591
Appears in Collections:
Trypanosomiasis/Sleeping Sickness

Full metadata record

DC FieldValue Language
dc.contributor.authorAlirol, Emilieen_GB
dc.contributor.authorSchrumpf, Daviden_GB
dc.contributor.authorAmici Heradi, Josuéen_GB
dc.contributor.authorRiedel, Andreaen_GB
dc.contributor.authorde Patoul, Catherineen_GB
dc.contributor.authorQuere, Michelen_GB
dc.contributor.authorChappuis, Françoisen_GB
dc.date.accessioned2013-10-16T20:00:26Z-
dc.date.available2013-10-16T20:00:26Z-
dc.date.issued2012-11-09-
dc.identifier.citationNifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo. 2013, 56 (2):195-203 Clin. Infect. Dis.en_GB
dc.identifier.issn1537-6591-
dc.identifier.pmid23074318-
dc.identifier.doi10.1093/cid/cis886-
dc.identifier.urihttp://hdl.handle.net/10144/303511-
dc.descriptionTo access this article, click on "Additional Links"en_GB
dc.description.abstractExisting diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of nifurtimox-eflornithine combination therapy (NECT) has brought new hopes for patients in the second stage. While NECT has been rolled out in most endemic countries, safety data are scarce and derive only from clinical trials. The World Health Organization (WHO) coordinates a pharmacovigilance program to collect additional data on NECT safety and efficacy. We report here the results of 18 months of experience of NECT use in treatment centers run by Médecins Sans Frontières in the Democratic Republic of the Congo (DRC).en_GB
dc.language.isoenen
dc.publisherOxford University Pressen_GB
dc.relation.urlhttp://cid.oxfordjournals.org//cgi/reprint/56/2/195?ijkey=n6iCHos9f2/bE&keytype=ref&siteid=ciden_GB
dc.rightsArchived with thanks to Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America and Oxford University Pressen_GB
dc.titleNifurtimox-Eflornithine Combination Therapy for Second-stage Gambiense Human African Trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congoen
dc.contributor.departmentDivision of International and Humanitarian Medicine, University Hospitals of Geneva, Switzerland. emilie.alirol@hcuge.chen_GB
dc.identifier.journalClinical Infectious Diseases : an official publication of the Infectious Diseases Society of Americaen_GB

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