Variation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach

Hdl Handle:
http://hdl.handle.net/10144/311607
Title:
Variation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach
Authors:
Klarkowski, Derryck; Glass, Kathryn; O'Brien, Daniel; Lokuge, Kamalini; Piriou, Erwan; Shanks, Leslie
Journal:
PloS ONE
Abstract:
Recent trends to earlier access to anti-retroviral treatment underline the importance of accurate HIV diagnosis. The WHO HIV testing strategy recommends the use of two or three rapid diagnostic tests (RDTs) combined in an algorithm and assume a population is serologically stable over time. Yet RDTs are prone to cross reactivity which can lead to false positive or discordant results. This paper uses discordancy data from Médecins Sans Frontières (MSF) programmes to test the hypothesis that the specificity of RDTs change over place and time.
Affiliation:
Médecins sans Frontières, Operational Centre Amsterdam, Amsterdam, The Netherlands
Publisher:
Public Library of Science
Issue Date:
Nov-2013
URI:
http://hdl.handle.net/10144/311607
DOI:
10.1371/journal.pone.0081656
PubMed ID:
24282615
Language:
en
ISSN:
1932-6203
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorKlarkowski, Derrycken_GB
dc.contributor.authorGlass, Kathrynen_GB
dc.contributor.authorO'Brien, Danielen_GB
dc.contributor.authorLokuge, Kamalinien_GB
dc.contributor.authorPiriou, Erwanen_GB
dc.contributor.authorShanks, Leslieen_GB
dc.date.accessioned2014-01-20T20:41:49Z-
dc.date.available2014-01-20T20:41:49Z-
dc.date.issued2013-11-
dc.identifier.citationVariation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approach. 2013, 8 (11):e81656 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid24282615-
dc.identifier.doi10.1371/journal.pone.0081656-
dc.identifier.urihttp://hdl.handle.net/10144/311607-
dc.description.abstractRecent trends to earlier access to anti-retroviral treatment underline the importance of accurate HIV diagnosis. The WHO HIV testing strategy recommends the use of two or three rapid diagnostic tests (RDTs) combined in an algorithm and assume a population is serologically stable over time. Yet RDTs are prone to cross reactivity which can lead to false positive or discordant results. This paper uses discordancy data from Médecins Sans Frontières (MSF) programmes to test the hypothesis that the specificity of RDTs change over place and time.en_GB
dc.language.isoenen
dc.publisherPublic Library of Scienceen_GB
dc.rightsPublished by Public Library of Science, [url]http://www.plosone.org/[/url] Archived on this site by Open Access permissionen_GB
dc.subjectDiagnosticsen_GB
dc.subjectHIV/AIDSen_GB
dc.titleVariation in Specificity of HIV Rapid Diagnostic Tests over Place and Time: An Analysis of Discordancy Data Using a Bayesian Approachen
dc.contributor.departmentMédecins sans Frontières, Operational Centre Amsterdam, Amsterdam, The Netherlandsen_GB
dc.identifier.journalPloS ONEen_GB

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