The urgent need for clinical, diagnostic, and operational research for management of Buruli ulcer in Africa

Hdl Handle:
http://hdl.handle.net/10144/311608
Title:
The urgent need for clinical, diagnostic, and operational research for management of Buruli ulcer in Africa
Authors:
O'Brien, Daniel P; Comte, Eric; Serafini, Micaela; Ehounou, Geneviève; Antierens, Annick; Vuagnat, Hubert; Christinet, Vanessa; Hamani, Mitima D; du Cros, Philipp
Journal:
The Lancet Infectious Diseases
Abstract:
Despite great advances in the diagnosis and treatment of Buruli ulcer, it is one of the least studied major neglected tropical diseases. In Africa, major constraints in the management of Buruli ulcer relate to diagnosis and treatment, and accessibility, feasibility, and delivery of services. In this Personal View, we outline key areas for clinical, diagnostic, and operational research on this disease in Africa and propose a research agenda that aims to advance the management of Buruli ulcer in Africa. A model of care is needed to increase early case detection, to diagnose the disease accurately, to simplify and improve treatment, to reduce side-effects of treatment, to deal with populations with HIV and tuberculosis appropriately, to decentralise care, and to scale up coverage in populations at risk. This approach will require commitment and support to strategically implement research by national Buruli ulcer programmes and international technical and donor organisations, combined with adaptations in programme design and advocacy. A critical next step is to build consensus for a research agenda with WHO and relevant groups experienced in Buruli ulcer care or related diseases, and we call on on them to help to turn this agenda into reality.
Affiliation:
Manson Unit, Médecins Sans Frontières, London, UK; Department of Infectious Diseases, Geelong Hospital, Geelong, VIC, Australia; Department of Medicine and Infectious Diseases, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia. Electronic address: daniel.obrien@amsterdam.msf.org.
Publisher:
Elsevier
Issue Date:
2-Dec-2013
URI:
http://hdl.handle.net/10144/311608
DOI:
10.1016/S1473-3099(13)70201-9
PubMed ID:
24309480
Language:
en
ISSN:
1474-4457
Appears in Collections:
Other Diseases

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Brien, Daniel Pen_GB
dc.contributor.authorComte, Ericen_GB
dc.contributor.authorSerafini, Micaelaen_GB
dc.contributor.authorEhounou, Genevièveen_GB
dc.contributor.authorAntierens, Annicken_GB
dc.contributor.authorVuagnat, Huberten_GB
dc.contributor.authorChristinet, Vanessaen_GB
dc.contributor.authorHamani, Mitima Den_GB
dc.contributor.authordu Cros, Philippen_GB
dc.date.accessioned2014-01-20T20:51:57Z-
dc.date.available2014-01-20T20:51:57Z-
dc.date.issued2013-12-02-
dc.identifier.citationThe urgent need for clinical, diagnostic, and operational research for management of Buruli ulcer in Africa. 2013: Lancet Infect Disen_GB
dc.identifier.issn1474-4457-
dc.identifier.pmid24309480-
dc.identifier.doi10.1016/S1473-3099(13)70201-9-
dc.identifier.urihttp://hdl.handle.net/10144/311608-
dc.description.abstractDespite great advances in the diagnosis and treatment of Buruli ulcer, it is one of the least studied major neglected tropical diseases. In Africa, major constraints in the management of Buruli ulcer relate to diagnosis and treatment, and accessibility, feasibility, and delivery of services. In this Personal View, we outline key areas for clinical, diagnostic, and operational research on this disease in Africa and propose a research agenda that aims to advance the management of Buruli ulcer in Africa. A model of care is needed to increase early case detection, to diagnose the disease accurately, to simplify and improve treatment, to reduce side-effects of treatment, to deal with populations with HIV and tuberculosis appropriately, to decentralise care, and to scale up coverage in populations at risk. This approach will require commitment and support to strategically implement research by national Buruli ulcer programmes and international technical and donor organisations, combined with adaptations in programme design and advocacy. A critical next step is to build consensus for a research agenda with WHO and relevant groups experienced in Buruli ulcer care or related diseases, and we call on on them to help to turn this agenda into reality.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherElsevieren_GB
dc.rightsPublished by Elsevier Reproduced on this site with permission of Elsevier Ltd. Please see [url]http://www.thelancet.com/journals/laninf[/url] for further relevant comment.en_GB
dc.subjectBuruli ulceren_GB
dc.subjectNTDsen_GB
dc.titleThe urgent need for clinical, diagnostic, and operational research for management of Buruli ulcer in Africaen
dc.contributor.departmentManson Unit, Médecins Sans Frontières, London, UK; Department of Infectious Diseases, Geelong Hospital, Geelong, VIC, Australia; Department of Medicine and Infectious Diseases, Royal Melbourne Hospital, University of Melbourne, Melbourne, VIC, Australia. Electronic address: daniel.obrien@amsterdam.msf.org.en_GB
dc.identifier.journalThe Lancet Infectious Diseasesen_GB

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