Causes of false-positive HIV rapid diagnostic test results

Hdl Handle:
http://hdl.handle.net/10144/316420
Title:
Causes of false-positive HIV rapid diagnostic test results
Authors:
Klarkowski, Derryck; O'Brien, Daniel P; Shanks, Leslie; Singh, Kasha P
Journal:
Expert Review of Anti-Infective Therapy
Abstract:
HIV rapid diagnostic tests have enabled widespread implementation of HIV programs in resource-limited settings. If the tests used in the diagnostic algorithm are susceptible to the same cause for false positivity, a false-positive diagnosis may result in devastating consequences. In resource-limited settings, the lack of routine confirmatory testing, compounded by incorrect interpretation of weak positive test lines and use of tie-breaker algorithms, can leave a false-positive diagnosis undetected. We propose that heightened CD5+ and early B-lymphocyte response polyclonal cross-reactivity are a major cause of HIV false positivity in certain settings; thus, test performance may vary significantly in different geographical areas and populations. There is an urgent need for policy makers to recognize that HIV rapid diagnostic tests are screening tests and mandate confirmatory testing before reporting an HIV-positive result. In addition, weak positive results should not be recognized as valid except in the screening of blood donors.
Publisher:
Informa Healthcare
Issue Date:
Jan-2014
URI:
http://hdl.handle.net/10144/316420
DOI:
10.1586/14787210.2014.866516
PubMed ID:
24404993
Language:
en
ISSN:
1744-8336
Appears in Collections:
HIV/AIDS

Full metadata record

DC FieldValue Language
dc.contributor.authorKlarkowski, Derrycken_GB
dc.contributor.authorO'Brien, Daniel Pen_GB
dc.contributor.authorShanks, Leslieen_GB
dc.contributor.authorSingh, Kasha Pen_GB
dc.date.accessioned2014-05-01T17:49:12Z-
dc.date.available2014-05-01T17:49:12Z-
dc.date.issued2014-01-
dc.identifier.citationCauses of false-positive HIV rapid diagnostic test results. 2014, 12 (1):49-62 Expert Rev Anti Infect Theren_GB
dc.identifier.issn1744-8336-
dc.identifier.pmid24404993-
dc.identifier.doi10.1586/14787210.2014.866516-
dc.identifier.urihttp://hdl.handle.net/10144/316420-
dc.description.abstractHIV rapid diagnostic tests have enabled widespread implementation of HIV programs in resource-limited settings. If the tests used in the diagnostic algorithm are susceptible to the same cause for false positivity, a false-positive diagnosis may result in devastating consequences. In resource-limited settings, the lack of routine confirmatory testing, compounded by incorrect interpretation of weak positive test lines and use of tie-breaker algorithms, can leave a false-positive diagnosis undetected. We propose that heightened CD5+ and early B-lymphocyte response polyclonal cross-reactivity are a major cause of HIV false positivity in certain settings; thus, test performance may vary significantly in different geographical areas and populations. There is an urgent need for policy makers to recognize that HIV rapid diagnostic tests are screening tests and mandate confirmatory testing before reporting an HIV-positive result. In addition, weak positive results should not be recognized as valid except in the screening of blood donors.en_GB
dc.language.isoenen
dc.publisherInforma Healthcareen_GB
dc.rightsArchived with thanks to Expert Review of Anti-Infective Therapyen_GB
dc.subjectDiagnosticsen_GB
dc.subjectHIV/AIDSen_GB
dc.titleCauses of false-positive HIV rapid diagnostic test resultsen
dc.identifier.journalExpert Review of Anti-Infective Therapyen_GB

Related articles on PubMed

All Items in MSF are protected by copyright, with all rights reserved, unless otherwise indicated.